Results 21 to 30 of about 478,975 (311)

Interleukin 12 (IL12B), interleukin 12 receptor (IL12RB1) and interleukin 23 (IL23A) gene polymorphism in systemic lupus erythematosus [PDF]

Rheumatology, 2005
The aim of this study was to assess the possible association between the interleukin-12B (IL12B) and interleukin-12 receptor beta 1 (IL12RB1) gene polymorphisms with systemic lupus erythematosus (SLE). In addition, we have undertaken a systematic search for genetic variants of interleukin 23 (IL23A).The study was conducted on 559 SLE patients and 603 ...
E, Sánchez, S, Morales, L, Paco, M A, López-Nevot, C, Hidalgo, J, Jiménez-Alonso, B, Torres, M A, González-Gay, J L, Callejas, N, Ortego-Centeno, J, Sánchez-Roman, M F, González-Escribano, J, Martín   +12 more
openaire   +2 more sources

Interleukin-18 Increases TLR4 and Mannose Receptor Expression and Modulates Cytokine Production in Human Monocytes

Mediators of Inflammation, 2015
Interleukin-18 is a proinflammatory cytokine belonging to the interleukin-1 family of cytokines. This cytokine exerts many unique biological and immunological effects.
Luciane Alarcão Dias-Melicio, Reginaldo Keller Fernandes, Daniela Ramos Rodrigues, Marjorie Assis Golim, Angela Maria Victoriano Campos Soares   +4 more
doaj   +1 more source

Inhibition of IL-12 heterodimers impairs TLR9-mediated prevention of early mouse plasmacytoma cell growth

Frontiers in Medicine, 2023
IntroductionNatural prevention of cancer development depends on an efficient immunosurveillance that may be modulated by environmental factors, including infections.
Mohamed F. Mandour, Mohamed F. Mandour, Pyone Pyone Soe, Pyone Pyone Soe, Anne-Sophie Castonguay, Anne-Sophie Castonguay, Jacques Van Snick, Jacques Van Snick, Jean-Paul Coutelier, Jean-Paul Coutelier   +9 more
doaj   +1 more source

Total RNA and genomic DNA of Lactobacillus gasseri OLL2809 induce interleukin-12 production in the mouse macrophage cell line J774.1 via toll-like receptors 7 and 9

BMC Microbiology, 2020
Background Lactobacillus gasseri OLL2809 can highly induce interleukin (IL)-12 production in immune cells. Even though beneficial properties of this strain for both humans and animals have been reported, the mechanism by which the bacteria induces the ...
Kazumasa Onishi, Junko Mochizuki, Asako Sato, Ayako Goto, Toshihiro Sashihara   +4 more
doaj   +1 more source

Polymorphisms in genes of interleukin 12 and its receptors and their association with protection against severe malarial anaemia in children in western Kenya

Malaria Journal, 2010
Background Malarial anaemia is characterized by destruction of malaria infected red blood cells and suppression of erythropoiesis. Interleukin 12 (IL12) significantly boosts erythropoietic responses in murine models of malarial anaemia and decreased IL12
Slutsker Laurence, Lal Altaf A, Terlouw Dianne, Nahlen Bernard, Kariuki Simon, ter Kuile Feiko, Crawford Sara, Eng Jodi, Prather Donald, Zhang Lyna, Udhayakumar Venkatachalam, Shi Ya   +11 more
doaj   +1 more source

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease [PDF]

, 2009
Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2 cytokines are modulators of ulcerative colitis. This concept has been challenged by the description of tolerising regulatory T cells (Treg) and by proinflammatory ...
Brand, Stephan
core   +1 more source

Post-ischaemic immunological response in the brain: targeting microglia in ischaemic stroke therapy [PDF]

, 2020
Microglia, the major endogenous immune cells of the central nervous system, mediate critical degenerative and regenerative responses in ischaemic stroke.
Chen, Ruoli, Dallas, Mark L., Jenkins, Stuart, Rawlinson, Charlotte, Thei, Laura   +4 more
core   +3 more sources

Dendritic Cells as Danger-Recognizing Biosensors

Sensors, 2009
Dendritic cells (DCs) are antigen presenting cells that are characterized by a potent capacity to initiate immune responses. DCs comprise several subsets with distinct phenotypes.
Seokmann Hong, Wooseok Im, Mia Gi
doaj   +1 more source

Integrated Analysis of circRNA-miRNA-mRNA Regulatory Networks in the Intestine of Sebastes schlegelii Following Edwardsiella tarda Challenge

Frontiers in Immunology, 2021
Sebastes schlegelii, an important aquaculture species, has been widely cultured in East Asian countries. With the increase in the cultivation scale, various diseases have become major threats to the industry.
Min Cao, Xu Yan, Baofeng Su, Ning Yang, Qiang Fu, Ting Xue, Lin Song, Qi Li, Chao Li   +8 more
doaj   +1 more source

Interleukin-1 blockade in heart failure with preserved ejection fraction: rationale and design of the Diastolic Heart Failure Anakinra Response Trial 2 (D-HART2) [PDF]

, 2017
Heart failure with preserved ejection fraction (HFpEF) now accounts for the majority of con-firmed HF cases in the United States. However, there are no highly effective evidence-basedtreatments currently available for these patients.
Abbate, Antonio, Abouzaki, Nayef, Arena, Ross, Biondi-zoccai, Giuseppe, Buckley, Leo F., Canada, Justin M., Carbone, Salvatore, Dixon, Dave L., Oddi-erdle, Claudia, Trankle, Cory R., Van Tassell, Benjamin W.   +10 more
core   +1 more source