Results 271 to 280 of about 475,125 (292)

Measles: immunosuppression, interleukin‐12. and complement receptors

Immunological Reviews, 1999
Summary: Measles virus, the first pathogen recognized to cause immunosuppression, induces profound and prolonged abnormalities in cellular immune responses in infected hosts. The ability of measles virus to specifically ablate monocyte/macrophage and dendritic cell production of interleukin (IL)‐12 provides a potentially unifying mechanism for many of
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Interleukin-12 Receptor β1 Polymorphisms and Nontuberculous Mycobacterial Lung Diseases

Lung, 2008
The pathway involving interferon-gamma and interleukin (IL)-12 plays an important role in host defense against mycobacterial infections. Recent studies have indicated that IL-12 receptor beta1 (IL-12Rbeta1) gene polymorphisms are associated with susceptibility to pulmonary tuberculosis.
Hye Yun, Park, Yong Soo, Kwon, Chang-Seok, Ki, Gee Young, Suh, Man Pyo, Chung, Hojoong, Kim, O Jung, Kwon, Won-Jung, Koh   +7 more
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Autoantibodies in patients with interleukin 12 receptor beta 1 deficiency

Journal of Digestive Diseases, 2019
ObjectiveInterleukin 12 receptor beta 1 (IL‐12Rβ1) deficiency is a primary immunodeficiency that exposes affected individuals to an augmented risk of intracellular pathogen‐mediated infections. The paradoxical presence of autoimmune manifestations in immune‐deficient patients has been recognized, but the basis of this phenomenon is unclear, with the ...
Ronca V., Chen Q. B., Lygoura V., Ben-Mustapha I., Shums Z., Trifa M., Carbone M., Mancuso C., Milani C., Bernuzzi F., Ma X., Agrebi N., Norman G. L., Chang C., Gershwin M. E., Barbouche M. -R., Invernizzi P.   +16 more
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Impairment of Mycobacterial Immunity in Human Interleukin-12 Receptor Deficiency

Science, 1998
In humans, interferon γ (IFN-γ) receptor deficiency leads to a predisposition to mycobacterial infections and impairs the formation of mature granulomas. Interleukin-12 (IL-12) receptor deficiency was found in otherwise healthy individuals with mycobacterial infections.
F, Altare, A, Durandy, D, Lammas, J F, Emile, S, Lamhamedi, F, Le Deist, P, Drysdale, E, Jouanguy, R, Döffinger, F, Bernaudin, O, Jeppsson, J A, Gollob, E, Meinl, A W, Segal, A, Fischer, D, Kumararatne, J L, Casanova   +16 more
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Regulation of interleukin‐12 receptor β1 chain expression and interleukin‐12 binding by human peripheral blood mononuclear cells

European Journal of Immunology, 1997
AbstractThe interleukin‐12 receptor (IL‐12R)β1 chain is an essential component of the functional IL‐12R on both human T and natural killer cells. In this report it is shown that activation of human peripheral blood mononuclear cells (PBMC) with anti‐CD3 monoclonal antibody (mAb) or phytohemagglutinin resulted in the up‐regulation of IL‐12Rβ1 expression
C, Wu, R R, Warrier, X, Wang, D H, Presky, M K, Gately   +4 more
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Interleukin-12 Induces Tyrosine Phosphorylation of an 85-kDa Protein Associated with the Interleukin-12 Receptor β1 Subunit

Cellular Immunology, 1998
Interleukin-12 (IL12) is a heterodimeric cytokine composed of p35 and p40 subunits and having multiple immunomodulatory effects on T cells as well as on natural killer cells. Two subunits, beta 1 and beta 2, consisting of the functional IL12 receptor complex, have been recently identified as members of the hemopoietin receptor superfamily, bearing ...
T, Kawashima, H, Kawasaki, T, Kitamura, Y, Nojima, C, Morimoto   +4 more
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Genomic organization of the human interleukin-12 receptor β 2 -chain gene

Immunogenetics, 2000
The interleukin-12 receptor (IL-12R) is composed of two subunits, referred to as beta1 and beta2. Both chains are necessary for high-affinity IL-12 binding and signalling, although only the IL-12Rbeta2 chain contains the intracellular tyrosine residues responsible for STAT4 activation.
van Rietschoten, J. G., Smits, H. H., Westland, R., Verweij, C. L., den Hartog, M. T., Wierenga, E. A.   +5 more
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Molecular Biology of lnterleukin‐12 Receptors

Annals of the New York Academy of Sciences, 1996
IL-12 receptors are expressed primarily on activated T and NK cells. Using labeled IL-12, three classes of IL-12-binding sites have been identified on human PHA-activated lymphoblasts. Their Kd values are 5-20 pM (high affinity), 50-200 pM (intermediate affinity), and 2-6 nM (low affinity).
U, Gubler, D H, Presky
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Biological function and distribution of human interleukin‐12 receptor β chain

European Journal of Immunology, 1996
AbstractWe previously described the cloning of a cDNA encoding an interleukin‐12 receptor (IL‐12R) subunit, designated β, that bound IL‐12 with low affinity when expressed in COS cells. We now report that a pair of monoclonal antibodies (mAb), 2B10 and 2.4E6, directed against different epitopes on the IL‐12Rβ chain, when used in combination, strongly ...
C Y, Wu, R R, Warrier, D M, Carvajal, A O, Chua, L J, Minetti, R, Chizzonite, P K, Mongini, A S, Stern, U, Gubler, D H, Presky, M K, Gately   +10 more
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Interleukin-12 Receptor β2: From Cytokine Receptor to Gatekeeper Gene in Human B-Cell Malignancies

Journal of Clinical Oncology, 2009
Interleukin (IL) -12 is a cytokine that has been extensively characterized for its immunoregulatory activities. IL-12 binds to a heterodimeric receptor composed of the β1 and β2 chains. In this review article, we discuss recent findings on the expression and function of IL-12 receptor (IL-12R) in malignant B cells frozen at various stages of ...
Vito, Pistoia, Claudia, Cocco, Irma, Airoldi   +2 more
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