Results 71 to 80 of about 446,676 (208)

Receptor for Interleukin 13 [PDF]

Journal of Biological Chemistry, 1995
Nicholas I. Obiri, Waldemar Debinski, Warren J. Leonard, Raj K. Puri   +3 more
openaire   +2 more sources

IL‐19 induced by IL‐13/IL‐17A in the nasal epithelium of patients with chronic rhinosinusitis upregulates MMP‐9 expression via ERK/NF‐κB signaling pathway

Clinical and Translational Allergy, 2021
Background Tissue remodeling is a crucial characteristic of chronic rhinosinusitis (CRS). Imbalance between matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) is crucial for the pathologic tissue remodeling in CRS ...
Xia Li, Jiancong Huang, Xiaohong Chen, Xiaoping Lai, Zizhen Huang, Yue Li, Shuaixiang Li, Lihong Chang, Gehua Zhang   +8 more
doaj   +1 more source

IL-13R alpha 2 reverses the effects of IL-13 and IL-4 on bronchial reactivity and acetylcholine-induced Ca2+ signaling [PDF]

, 2007
Background: The interleukins IL-4 and IL-13 play a key role in the pathophysiology of asthma. The interleukin receptor IL-13R alpha 2 is believed to act as a decoy receptor, but until now, the functional significance of IL-13R alpha 2 remains vague ...
Bergner, Albrecht, Gamarra, Fernando, Huber, Rudolf M., Joerres, Rudolf A., Kellner, Julia, Welsch, Ulrich   +5 more
core   +1 more source

Interleukin 13 and Interleukin 4 Receptor-α Polymorphisms in Rhinitis and Asthma [PDF]

International Archives of Allergy and Immunology, 2010
<i>Background:</i> Asthma and rhinitis may represent two manifestations of the same airway disease. Genetic research can increase our understanding of their common or distinct pathogenesis. <i>IL13</i> and <i>IL4R</i> polymorphisms are associated with asthma and show gene-gene interaction in asthma.
Bottema, Renske W. B., Nolte, Ilja M., Howard, Timothy D., Koppelman, Gerard H., Dubois, Anthony E. J., de Meer, Gea, Kerkhof, Marjan, Bleecker, Eugene R., Meyers, Deborah A., Postma, Dirkje S.   +9 more
openaire   +3 more sources

Fibroblast activation protein-targeted-4-1BB ligand agonist amplifies effector functions of intratumoral T cells in human cancer

Journal for ImmunoTherapy of Cancer, 2020
Background The costimulatory receptor 4-1BB (CD137, TNFRSF9) plays an important role in sustaining effective T cell immune responses and is investigated as target for cancer therapy.
Alfred Zippelius, Petra Herzig, Heinz Läubli, Vaios Karanikas, Gieri Cathomas, Christian Klein, Marta Trüb, Franziska Uhlenbrock, Christina Claus, Martin Thelen, Marina Bacac, Maria Amann, Rosemarie Albrecht, Claudia Ferrara-Koller, Daniela Thommen, Sacha Rothschield, Spasenija Savic Prince, Kirsten D Mertz, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Abhishek S Kashyap   +23 more
doaj   +1 more source

Anti-IL-20 monoclonal antibody inhibited inflammation and protected against cartilage destruction in murine models of osteoarthritis. [PDF]

PLoS ONE, 2017
Osteoarthritis (OA) is a degenerative joint disease characterized by progressive destruction of articular cartilage. Interleukin (IL)-20 is a proinflammatory cytokine involved in the pathogenesis of rheumatoid arthritis. We investigated the role of IL-20
Yu-Hsiang Hsu, Ya-Yu Yang, Man-Hsiang Huwang, Yun-Han Weng, I-Ming Jou, Po-Tin Wu, Tain-Yu Lin, Li-Wha Wu, Ming-Shi Chang   +8 more
doaj   +1 more source

Leukemia Inhibitory Factor Represses GnRH Gene Expression via cFOS during Inflammation in Male Mice. [PDF]

, 2019
BackgroundThe mechanisms whereby neuroinflammation negatively affects neuronal function in the hypothalamus are not clear. Our previous study determined that obesity-mediated chronic inflammation elicits sex-specific impairment in reproductive function ...
Coss, Djurdjica, Lainez, Nancy M
core   +1 more source

The gut-brain axis, BDNF, NMDA and CNS disorders [PDF]

, 2016
Gastro-intestinal (GI) microbiota and the ‘gut-brain axis’ are proving to be increasingly relevant to early brain development and the emergence of psychiatric disorders.
Maqsood, Raeesah, Stone, Trevor W.
core   +1 more source

Restoration of Tumor Immunosurveillance via Targeting of Interleukin-13 Receptor-α2 [PDF]

Cancer Research, 2008
AbstractIn previous studies, we described a “counter-immunosurveillance” mechanism initiated by tumor-activated, interleukin-13 (IL-13)–producing natural killer T cells that signal Gr-1+ cells to produce transforming growth factor-β1 (TGF-β1), a cytokine that suppresses the activity of tumor-inhibiting cytolytic CD8+ T cells.
Stefan, Fichtner-Feigl, Masaki, Terabe, Atsushi, Kitani, Cheryl A, Young, Ivan, Fuss, Edward K, Geissler, Hans-Jürgen, Schlitt, Jay A, Berzofsky, Warren, Strober   +8 more
openaire   +2 more sources

Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model [PDF]

, 2013
© 2013 Peake et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Achan, P, Bader, DL, Chowdhury, TT, Hobbs, AJ, Moyes, AJ, Peake, N, Ramachandran, M, Salter, DM, Su, N   +8 more
core   +3 more sources