Results 71 to 80 of about 442,994 (306)

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

The Interleukin-17 Induced Activation and Increased Survival of Equine Neutrophils Is Insensitive to Glucocorticoids. [PDF]

PLoS ONE, 2016
BACKGROUND:Glucocorticoids (GCs) are the most effective drugs for the treatment of human asthma. However, a subgroup of asthmatic patients with neutrophilic airway inflammation is insensitive to GCs.
Ruby Yoana Murcia, Amandine Vargas, Jean-Pierre Lavoie   +2 more
doaj   +1 more source

Investigation of the role of endosomal Toll-like receptors in murine collagen-induced arthritis reveals a potential role for TLR7 in disease maintenance [PDF]

, 2012
INTRODUCTION Endosomal toll-like receptors (TLRs) have recently emerged as potential contributors to the inflammation observed in human and rodent models of rheumatoid arthritis (RA).
Alzabin, Saba, Kong, Philip, Medghalchi, Mino, Palfreeman, Andrew, Sacre, Sandra, Williams, Richard   +5 more
core   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

IL-5 and GM-CSF, but Not IL-3, Promote the Proliferative Properties of Inflammatory-like and Lung Resident-like Eosinophils in the Blood of Asthma Patients

Cells, 2022
Blood eosinophils can be described as inflammatory-like (iEOS-like) and lung-resident-like (rEOS-like) eosinophils. This study is based on the hypothesis that eosinophilopoetins such as interleukin (IL)-3 and IL-5 and granulocyte-macrophage colony ...
Jolita Palacionyte, Andrius Januskevicius, Egle Vasyle, Airidas Rimkunas, Ieva Bajoriuniene, Skaidrius Miliauskas, Kestutis Malakauskas   +6 more
doaj   +1 more source

Interleukin-17 Receptor A Signaling in Transformed Enterocytes Promotes Early Colorectal Tumorigenesis [PDF]

Immunity, 2014
Interleukin-17A (IL-17A) is a pro-inflammatory cytokine linked to rapid malignant progression of colorectal cancer (CRC) and therapy resistance. IL-17A exerts its pro-tumorigenic activity through its type A receptor (IL-17RA). However, IL-17RA is expressed in many cell types, including hematopoietic, fibroblastoid, and epithelial cells, in the tumor ...
Wang, Kepeng, Kim, Min Kyoung, Di Caro, Giuseppe, Wong, Jerry, Shalapour, Shabnam, Wan, Jun, Zhang, Wei, Zhong, Zhenyu, Sanchez-Lopez, Elsa, Wu, Li-Wha, Taniguchi, Koji, Feng, Ying, Fearon, Eric, Grivennikov, Sergei I., Karin, Michael   +14 more
openaire   +3 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Recognition of Candida albicans and Role of Innate Type 17 Immunity in Oral Candidiasis

Microorganisms, 2020
Candida albicans is an opportunistic pathogenic fungus considered to be a common member of the human microflora. Similar to some other opportunistic microbes, C.
Anna Pavlova, Irshad Sharafutdinov
doaj   +1 more source

Lower peripheral blood Toll-like receptor 3 expression is associated with an unfavorable outcome in severe COVID-19 patients

Scientific Reports, 2021
The role of innate immunity in COVID-19 is not completely understood. Therefore, this study explored the impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection on the expression of Pattern Recognition Receptors (PRRs) in ...
Maria Clara Saad Menezes, Alicia Dudy Müller Veiga, Thais Martins de Lima, Suely Kunimi Kubo Ariga, Hermes Vieira Barbeiro, Claudia de Lucena Moreira, Agnes Araujo Sardinha Pinto, Rodrigo Antonio Brandao, Julio Flavio Marchini, Julio Cesar Alencar, Lucas Oliveira Marino, Luz Marina Gomez, Niels Olsen Saraiva Camara, Heraldo P. Souza   +13 more
doaj   +1 more source

Cross-disease innate gene signature: Emerging diversity and abundance in RA comparing to SLE and SSc [PDF]

, 2019
Overactivation of the innate immune system together with the impaired downstream pathway of type I interferon-responding genes is a hallmark of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc).
Fillerová, Regina, Horák, Pavel, Kriegová, Eva, Kudělka, Miloš, Mrázek, František, Petráčková, Anna, Radvanský, Martin, Skácelová, Martina, Smržová, Andrea   +8 more
core   +1 more source