Results 61 to 70 of about 442,994 (306)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Journal of Immunology Research, 2019 Leprosy reactions are acute immunological events that occur during the evolution of chronic infectious disease causing neural damage and disabilities.
Douglas Eulálio Antunes +5 more
doaj +1 more source
Interleukin-17A promotes parietal cell atrophy by inducing apoptosis [PDF]
, 2018 Background & Aims: Atrophic gastritis caused by chronic inflammation in the gastric mucosa leads to the loss of gastric glandular cells, including acid-secreting parietal cells.
Alderuccio +47 more
core +3 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
BiomoleculesNuclear receptors (NRs) are transcription factors regulated by ligands that direct metabolism, development, and immunity. The NR superfamily constitutes a principal category of pharmacological targets for human ailments.
Anik Pramanik +2 more
doaj +1 more source
Analysis of Chemical Composition and Pharmacological Activity of Fengdan Peony Pods [PDF]
Shipin KexueThe purpose of this study was to explore the bioactive components of Fengdan peony pods and their mechanisms of action by using network pharmacology and molecular docking.
ZHANG Yanping, ZHANG Chenxi, ZUO Haichao, GAO Di, WU Qiqi, SONG Yafei, ZHAO Liyuan
doaj +1 more source
Interleukin-17 receptor polymorphism predisposes to primary graft dysfunction after lung transplantation [PDF]
The Journal of Heart and Lung Transplantation, 2015 Primary graft dysfunction (PGD), with an incidence of 11% to 57%, is a major cause of morbidity and mortality within the first 30 days after lung transplantation (LTx). In this study, we postulate that recipient genetic variants in interleukin-17 and -23 receptor genes (IL-17R and IL-23R, respectively) may predispose LTx recipients to an increased risk
Somers, Jana +10 more
openaire +4 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
The effect of exercise on plasma soluble IL-6 receptor concentration: a dichotomous response [PDF]
, 2010 The aim of this article is to review current literature on the response of soluble interleukin-6 receptor to exercise and identify a potential role for sIL-6R in skeletal muscle function.
Cockburn, Emma +4 more
core
The onset of labor alters corticotropin-releasing hormone type 1 receptor variant expression in human myometrium : putative role of interleukin-1ß [PDF]
, 2007 CRH targets the human myometrium during pregnancy. The efficiency of CRH actions is determined by expression of functional receptors (CRH-R), which are dynamically regulated.
Grammatopoulos, Dimitris +6 more
core +1 more source