Results 41 to 50 of about 289,750 (311)

Enhanced Th17 Responses in Patients with Autoimmune Hepatitis

Middle East Journal of Digestive Diseases, 2019
BACKGROUND T cells are major players in chronic inflammatory diseases such as autoimmune hepatitis (AIH). However, it is not clear which subset of T cells participates in the pathophysiology of the disease.
Farinaz Behfarjam, Siavash Nasseri-Moghaddam, Zohreh Jadali   +2 more
doaj   +1 more source

Exploring causal associations between interleukins, their receptors, and acute respiratory distress syndrome: a bidirectional-Mendelian Randomization study

Frontiers in Genetics
BackgroundAcute Respiratory Distress Syndrome (ARDS) is a severe lung condition posing significant health risks. Observational studies have indicated a potential linkage between ARDS and various interleukins, such as Interleukin-8, −2, −6, and −1β ...
Jia-wei Ma, Jia-wei Ma, Ji-chun Tang, Hong-zhi Fang   +3 more
doaj   +1 more source

Interleukin-17A: The Key Cytokine in Neurodegenerative Diseases

Frontiers in Aging Neuroscience, 2020
Neurodegenerative diseases are characterized by the loss of neurons and/or myelin sheath, which deteriorate over time and cause dysfunction. Interleukin 17A is the signature cytokine of a subset of CD4+ helper T cells known as Th17 cells, and the IL-17 ...
Junjue Chen, Xiaohong Liu, Yisheng Zhong
doaj   +1 more source

An essential role of interleukin-17 receptor signaling in the development of autoimmune glomerulonephritis [PDF]

Journal of Leukocyte Biology, 2014
AbstractIn recent years, proinflammatory cytokines in the nephritic kidney appear to contribute to the pathogenesis of AGN. The complex inflammatory cytokine network that drives renal pathology is poorly understood. IL-17, the signature cytokine of Th17 cells, which promotes autoimmune pathology in a variety of settings, is beginning to be identified ...
Kritika, Ramani, Sudesh, Pawaria, Kelly, Maers, Anna R, Huppler, Sarah L, Gaffen, Partha S, Biswas   +5 more
openaire   +2 more sources

Bradykinin B2 receptors of dendritic cells, acting as sensors of kinins proteolytically released by Trypanosoma cruzi, are critical for the development of protective type-1 responses

, 2007
Although the concept that dendritic cells (DCs) recognize pathogens through the engagement of Toll-like receptors is widely accepted, we recently suggested that immature DCs might sense kinin-releasing strains of Trypanosoma cruzi through the triggering ...
Müller-Esterl Werner, Alessandra Granato, Schmitz Verônica, Scharfstein Julio, Tanowitz Herbert B, Scharfstein, Julio, Werner Müller-Esterl, Fnu Nagajyothi, de Arruda Luciana Barros, Nagajyothi, Fnu, Granato Alessandra, Pesquero João B, Müller-Esterl, Werner, Schmitz, Verônica, Luciana Barros de Arruda, Alexandre Morrot, Granato, Alessandra, Barros de Arruda, Luciana, Morrot Alexandre, Monteiro, Ana Carolina, Tanowitz, Herbert B., Julio Scharfstein, Nagajyothi Fnu, Morrot, Alexandre, Verônica Schmitz, João B Pesquero, Pesquero, João B., Monteiro Ana Carolina, Ana Carolina Monteiro, Herbert B Tanowitz   +29 more
core   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

The Deubiquitinase A20 Mediates Feedback Inhibition of Interleukin-17 Receptor Signaling [PDF]

Science Signaling, 2013
Inhibition of an inflammatory cytokine signaling pathway by A20 at the receptor may play a role in preventing autoimmunity.
Abhishek V, Garg, Mushtaq, Ahmed, Abbe N, Vallejo, Averil, Ma, Sarah L, Gaffen   +4 more
openaire   +2 more sources

The onset of labor alters corticotropin-releasing hormone type 1 receptor variant expression in human myometrium : putative role of interleukin-1ß [PDF]

, 2007
CRH targets the human myometrium during pregnancy. The efficiency of CRH actions is determined by expression of functional receptors (CRH-R), which are dynamically regulated.
Gu, Mei, Grammatopoulos, Dimitris, Markovic, Danijela, Slater, Donna, Newton, Rob, Vatish, Manu, Lehnert, Hendrik   +6 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Critical Role of the Interleukin-17/Interleukin-17 Receptor Axis in Regulating Host Susceptibility to Respiratory Infection withChlamydiaSpecies [PDF]

Infection and Immunity, 2009
ABSTRACTThe specific contribution of interleukin-17/interleukin-17 receptor (IL-17/IL-17R)-mediated responses in regulating host susceptibility against obligatory intracellularChlamydiainfection was investigated in C57BL/6 and C3H/HeN mice duringChlamydia muridarumrespiratory infection.
Xiaohui, Zhou, Qiangwei, Chen, Jessica, Moore, Jay K, Kolls, Scott, Halperin, Jun, Wang   +5 more
openaire   +2 more sources