Results 21 to 30 of about 289,750 (311)

B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response [PDF]

, 2013
We have previously demonstrated that B cells can shape the immune response to Mycobacterium tuberculosis, including the level of neutrophil infiltration and granulomatous inflammation at the site of infection. The present study examined the mechanisms by
Porcelli, SA, Wang, Yanhua, Steven A. Porcelli, William R Jacobs, Flynn, Joanne L, Chen, Y, John Chan, Kozakiewicz, Lee, Qinglin Ou, Lee Kozakiewicz, Chan, John, Xu, J, Ou, Qinglin, Yong Chen (109188), John Chan (47914), Jacobs, WR, Flynn, JL, Ou, Q, Jacobs, William R, William R. Jacobs, Dunussi-Joannopoulos, K, Dunussi-Joannopoulos, Kyri, Steven A. Porcelli (47915), Chen, Yong, Joanne L Flynn, Xu, Jiayong, Kozakiewicz, L, Jiayong Xu (432778), Wang, Y, Joanne L. Flynn (5655565), William R. Jacobs Jr (199645), Chan, J, Lee Kozakiewicz (432777), Qinglin Ou (432779), Joanne L. Flynn, Yanhua Wang, Porcelli, Steven A, Yanhua Wang (127897), Jiayong Xu, Steven A Porcelli, Yong Chen, Kyri Dunussi-Joannopoulos, Kyri Dunussi-Joannopoulos (344714)   +42 more
core   +1 more source

Downregulation of Chicken Interleukin-17 Receptor A during Eimeria Infection [PDF]

Infection and Immunity, 2014
ABSTRACT Both interleukin-17A (IL-17A) and IL-17F are proinflammatory cytokines that have an important role in intestinal homeostasis via receptor signaling. These cytokines have been characterized in chickens, but very little is known about their receptors and their functional activity.
Woo H, Kim, Jipseol, Jeong, Ae R, Park, Dongjean, Yim, Suk, Kim, Hong H, Chang, Seung-Hak, Yang, Dong-Hee, Kim, Hyun S, Lillehoj, Wongi, Min   +9 more
openaire   +2 more sources

Clinical significance of Interleukin 17 receptor E in diabetic nephropathy

International Immunopharmacology, 2023
Diabetic nephropathy (DN) is a leading cause of end-stage renal disease. Since there are limited therapeutic options available for the prevention of DN progression, it is imperative to explore novel differentially expressed genes and therapeutic targets for DN.In this study, mice kidney tissue were subjected to transcriptome sequencing and the results ...
Jingjing Wang, Xian Wang, Meixi Wang, Jinni Wang, Yonggui Wu, Xiangming Qi   +5 more
openaire   +2 more sources

Nanometer-scale organization of the alpha subunits of the receptors for IL2 and IL15 in human T lymphoma cells [PDF]

, 2008
Interleukin 2 and interleukin 15 (IL2 and IL15, respectively) provide quite distinct contributions to T-cell-mediated immunity, despite having similar receptor composition and signaling machinery.
Bodnár, Andrea, Garcia Parajo, M.F., van Dijk, E.M.H.P., Jenei, Attila, Andrea Bodnár, Thomas A. Waldmann, Garcia-Parajo, Maria F., Hulst, Niek F., van, Sándor Damjanovich, Attila Jenei, Bakker, B. I. de, van Hulst, N.F., Damjanovich, Sándor, Dóczy-Bodnár, Andrea, György Vámosi, Dijk, Erik M. H. P., van, Waldmann, Thomas A., María F. Garcia-Parajo, Niek F. van Hulst, de Bakker, Bärbel I., Vámosi, György, Erik M. H. P. van Dijk, Dijk, E. M. H. P. van, de Bakker, B.I., Bärbel I. de Bakker   +24 more
core   +1 more source

Association of a non-synonymous SNP of IL17RA gene with litter size traits in Large White and Landrace pigs

Veterinary Integrative Sciences, 2021
Interleukin-17 receptor A (IL17RA) is one of the cytokine receptors of the pro-inflammatory interleukin-17 (IL17) cytokine family. The IL17 and IL17RA genes are involved in inflammatory and immune responses as well as reproductive process of ...
Worrarak Norseeda, Guisheng Liu, Tawatchai Teltathum, Korawan Sringarm, Watcharapong Naraballobh, Trisadee Khamlor, Supamit Mekchay   +6 more
doaj   +1 more source

Immune and Inflammatory Pathways in Non-Alcoholic Steatohepatitis (NASH). An update

Journal of Mind and Medical Sciences, 2019
Non-alcoholic steatohepatitis (NASH), also known as fatty liver disease (FLD), is a major public health problem. It is considered to be the hepatic manifestation of the metabolic syndrome.
Sorina Cezara Coste, Ionela Popovici, Andreea Maria Stefan, Iulia Breaban, Adela Sitar Taut, Simina Tarmure Sarlea, Angela Cozma, Dorel Sampelean, Olga Hilda Orasan, Vasile Negrean, Lucia Maria Procopciuc   +10 more
doaj   +1 more source

Essential role of NK cells in IgG therapy for experimental autoimmune encephalomyelitis.

PLoS ONE, 2013
Intravenous immunoglobulin has long been used in treating autoimmune diseases, although mechanisms remain uncertain. Activating Fcγ receptors are receptors of IgG and reported to be essential in intravenous immunoglobulin (IVIG) therapy.
Wai Po Chong, Man To Ling, Yinping Liu, Rachel R Caspi, Wai Man Wong, Wutian Wu, Wenwei Tu, Yu Lung Lau   +7 more
doaj   +1 more source

The IL-17 family in diseases: from bench to bedside

Signal Transduction and Targeted Therapy, 2023
The interleukin-17 (IL-17) family comprises six members (IL-17A–17F), and recently, all of its related receptors have been discovered. IL-17 was first discovered approximately 30 years ago.
Longjie Huangfu, Ruiying Li, Yamei Huang, Shan Wang   +3 more
doaj   +1 more source

Truncated Chicken Interleukin-1β with Increased Biologic Activity [PDF]

, 2003
Chicken interleukin-1β (ChIL-1β) is synthesized as a precursor molecule that unlike its mammalian counterpart, lacks a typical caspase-1 cleavage site. Therefore, it was unclear if proteolytic cleavage of ChIL-1β can occur and if cleavage might modulate ...
Erno Duda, Zsuzsa Gyorfy, Duda, Erno, Stäheli, Peter, Peter Staeheli, Staeheli, Peter, Annette Ohnemus, Kaspers, Bernd, Gyorfy, Zsuzsa, Ohnemus, Annette, Bernd Kaspers   +10 more
core   +1 more source

Dexmedetomidine attenuates oxygen-glucose deprivation/ reperfusion-induced inflammation through the miR-17-5p/ TLR4/ NF-κB axis

BMC Anesthesiology, 2022
Background Dexmedetomidine (DEX) is a selective agonist of α2-adrenergic receptors with anesthetic activity and neuroprotective benefits. However, its mechanism of action at the molecular level remains poorly defined.
Liangyuan Suo, Mingyu Wang
doaj   +1 more source