Results 11 to 20 of about 442,994 (306)

Immunohistochemical expression of interleukin-17 and hormonal receptors in benign and malignant breast lesions

BMC Research Notes, 2020
Objectives IL17 is a critical pro-inflammatory cytokine that is involved in inflammation, multidrug resistance and growth persistence pathways in cancer.
Eman Taha Ali, Mai Abdulrahman Mohammed Masri, Emmanuel Edwar Siddig, Ayman Ahmed, Mohamed S. Muneer, Nouh Saad Mohamed, Ali Mahmoud Mohammed Edris   +6 more
doaj   +1 more source

MicroRNAs and other mechanisms regulate interleukin-17 cytokines and receptors [PDF]

Frontiers in Bioscience, 2012
Interleukin-17 cytokines are a family of pro-inflammatory cytokines. Our current studies found: i) IL-17 cytokines are not ubiquitously expressed, but several receptors and TRAF3IP2 are ubiquitously expressed in tissues with a few exceptions; ii) heart and vascular tissue are in the second tier of readiness to respond to IL-17 cytokine stimulation; iii)
Jietang, Mai, Anthony, Virtue, Erin, Maley, Tran, Tran, Ying, Yin, Shu, Meng, Meghana, Pansuria, Xiaohua, Jiang, Hong, Wang, Xiao-Feng, Yang   +9 more
openaire   +3 more sources

Biological injection therapy with leukocyte-poor platelet-rich plasma induces cellular alterations, enhancement of lubricin, and inflammatory downregulation in vivo in human knees: A controlled, prospective human clinical trial based on mass spectrometry imaging analysis

Frontiers in Surgery, 2023
ObjectiveTo investigate the in vivo biological effects of leukocyte-poor platelet-rich plasma (LpPRP) treatment in human synovial layer to establish the cellular basis for a prolonged clinical improvement.MethodsSynovial tissues (n = 367) were ...
Axel W. Baltzer, Rita Casadonte, Alexei Korff, Lea Merline Baltzer, Katharina Kriegsmann, Mark Kriegsmann, Mark Kriegsmann, Jörg Kriegsmann, Jörg Kriegsmann, Jörg Kriegsmann   +9 more
doaj   +1 more source

Structural basis of receptor sharing by interleukin 17 cytokines [PDF]

Nature Immunology, 2009
Interleukin 17 (IL-17)-producing helper T cells (T(H)-17 cells), together with their effector cytokines, including members of the IL-17 family, are emerging as key mediators of chronic inflammatory and autoimmune disorders. Here we present the crystal structure of a complex of IL-17 receptor A (IL-17RA) bound to IL-17F in a 1:2 stoichiometry.
Ely, Lauren K., Fischer, Suzanne, Garcia, K. Christopher   +2 more
openaire   +2 more sources

Impact of Adalimumab Treatment on Interleukin-17 and Interleukin-17 Receptor Expression in Skin and Synovium of Psoriatic Arthritis Patients with Mild Psoriasis

Biomedicines, 2022
Interleukin (IL)-17 and tumor necrosis factor-alpha (TNF)-α are key players in psoriatic arthritis (PsA) pathogenesis. While both cytokines can be therapeutically targeted with beneficial clinical outcome, it is unclear whether inhibiting one cytokine ...
Janne W. Bolt, Arno W. van Kuijk, Marcel B. M. Teunissen, Dennis van der Coelen, Saïda Aarrass, Daniëlle M. Gerlag, Paul P. Tak, Marleen G. van de Sande, Maria C. Lebre, Lisa G. M. van Baarsen   +9 more
doaj   +1 more source

Targeting interleukin-17 receptors

Oncotarget, 2015
During the last decade, increasing evidence suggests a strong association between chronic inflammation and cancer development among different types of cancer. The dysregulation of pro-inflammatory cytokines or their receptors is a common feature observed in many cancers [1]. Cancer cells take advantage of cytokine or cytokine receptor overexpression to
Wen-Hwa, Lee, Heng-Hsiung, Wu, Chun-Kai, Huang   +2 more
openaire   +2 more sources

Interleukin-25 Produced by Synoviocytes Has Anti-inflammatory Effects by Acting As a Receptor Antagonist for Interleukin-17A Function

Frontiers in Immunology, 2017
The production and function of cytokines are highly regulated. One mechanism is the balance between pro- and anti-inflammatory cytokines. As interleukin (IL)-17A and IL-25 share the IL-17RA receptor chain, we hypothesize that IL-25 acts as an IL-17A ...
Fabien Lavocat, Ndiémé Ndongo-Thiam, Pierre Miossec   +2 more
doaj   +1 more source

Increased IL-23R+ Th Cells Population Exhibits Higher SLEDAI-2K Scores in Systemic Lupus Erythematosus Patients

Frontiers in Immunology, 2021
The IL-23/IL-17 axis plays causative roles in the development and progression of systemic lupus erythematosus (SLE). However, it remains unclear if the IL-17RA+ and IL-23R+ T helper (Th) cells populations are associated with the serum IL-17 and IL-23 ...
Aziz Farah Izati, Aziz Farah Izati, Nur Diyana Mohd Shukri, Nur Diyana Mohd Shukri, Wan Syamimee Wan Ghazali, Wan Syamimee Wan Ghazali, Che Maraina Che Hussin, Che Maraina Che Hussin, Kah Keng Wong, Kah Keng Wong   +9 more
doaj   +1 more source

Reduction of circulating cholesterol and apolipoprotein levels during sepsis [PDF]

, 1999
Sepsis with multiple organ failure is frequently associated with a substantial decrease of cholesterol levels. This decrease of cholesterol is strongly associated with mortality suggesting a direct relation between inflammatory conditions and altered ...
Alvarez C, Chajek-Shaul T, Engelmann H, Ettinger WH, Ettinger WH, Ettinger WH, Feingold KR, Feingold KR, Flegel WA, Gouni I, Graham A, Greenberg AS, Grove RI, Grunfeld C, Hubsch AP, Ishibashi S, Kipp HA, Moran CS, Netea MG, Pacelli F, Pak YK, Read TE, Semb H, Stopeck AT, Van Gameren MM, Weinstock C, Wilson DE, Yokoyama K   +27 more
core   +1 more source

Downregulation of Chicken Interleukin-17 Receptor A during Eimeria Infection [PDF]

Infection and Immunity, 2014
ABSTRACT Both interleukin-17A (IL-17A) and IL-17F are proinflammatory cytokines that have an important role in intestinal homeostasis via receptor signaling. These cytokines have been characterized in chickens, but very little is known about their receptors and their functional activity.
Woo H, Kim, Jipseol, Jeong, Ae R, Park, Dongjean, Yim, Suk, Kim, Hong H, Chang, Seung-Hak, Yang, Dong-Hee, Kim, Hyun S, Lillehoj, Wongi, Min   +9 more
openaire   +2 more sources