Post-ischaemic immunological response in the brain: targeting microglia in ischaemic stroke therapy [PDF]
, 2020 Microglia, the major endogenous immune cells of the central nervous system, mediate critical degenerative and regenerative responses in ischaemic stroke.
Chen, Ruoli +4 more
core +3 more sources
SCFFBXW11 Complex Targets Interleukin-17 Receptor A for Ubiquitin–Proteasome-Mediated Degradation
Biomedicines, 2023 Interleukin-17 (IL-17) is a pro-inflammatory cytokine that participates in innate and adaptive immune responses and plays an important role in host defense, autoimmune diseases, tissue regeneration, metabolic regulation, and tumor progression. Post-translational modifications (PTMs) are crucial for protein function, stability, cellular localization ...
Ben Jin +6 more
openaire +3 more sources
Cytokines of Birds: Conserved Functions [PDF]
, 2001 Targeted disruptions of the mouse genes for cytokines, cytokine receptors, or components of cytokine signaling cascades convincingly revealed the important roles of these molecules in immunologic processes. Cytokines are used at present as drugs to fight
Göbel, Thomas W. F. +4 more
core +1 more source
Characterization and Potential Applications of Dog Natural Killer Cells in Cancer Immunotherapy. [PDF]
, 2019 Natural killer (NK) cells of the innate immune system are a key focus of research within the field of immuno-oncology based on their ability to recognize and eliminate malignant cells without prior sensitization or priming.
Canter, Robert J +2 more
core +2 more sources
Virus-Like Particle-Mediated Vaccination against Interleukin-13 May Harbour General Anti-Allergic Potential beyond Atopic Dermatitis [PDF]
, 2020 Virus-like particle (VLP)-based anti-infective prophylactic vaccination has been established in clinical use. Although validated in proof-of-concept clinical trials in humans, no VLP-based therapeutic vaccination against self-proteins to modulate chronic
Foerster, John, Molęda, Aleksandra
core +2 more sources
The Deubiquitinase A20 Mediates Feedback Inhibition of Interleukin-17 Receptor Signaling [PDF]
Science Signaling, 2013 Inhibition of an inflammatory cytokine signaling pathway by A20 at the receptor may play a role in preventing autoimmunity.
Abhishek V, Garg +4 more
openaire +2 more sources
No Association between Single-Nucleotide Polymorphisms of The S1PR1 Gene or Interleukin-17 Levels with Fingolimod Response in A Small Group of Iranian Relapsing-Remitting Multiple Sclerosis Patients: A Case-Control Study [PDF]
Cell JournalObjective: Multiple sclerosis (MS) has a multi-factorial etiology involving genetic factors. Fingolimod (Gilenya ®,FTY720) modulates the G-protein-coupled sphingosine 1-phosphate (S1P) receptors, S1PR1, 2, 3, 4 and 5.
Nasrin Moheghi +2 more
doaj +1 more source
Biomolecules, 2023 The neurohormone crustacean female sex hormone (CFSH) contains a highly conserved interleukin-17 (IL-17) domain in the mature peptide. Although CFSH has been demonstrated to stimulate female sexual differentiation in crustaceans, its receptors (CFSHR ...
Fang Liu, An Liu, Haihui Ye
doaj +1 more source
Interleukin‐17 sensitizes joint nociceptors to mechanical stimuli and contributes to arthritic pain through neuronal interleukin‐17 receptors in rodents [PDF]
Arthritis & Rheumatism, 2012 AbstractObjectiveInterleukin‐17 (IL‐17) is considered a proinflammatory cytokine, but whether neuronal IL‐17 receptors contribute to the generation of arthritic pain is unknown. This study was undertaken to explore whether IL‐17A acts on neurons, whether it sensitizes joint nociceptors, and whether neutralization of IL‐17 is antinociceptive.MethodsWe ...
Frank, Richter +7 more
openaire +2 more sources
Interleukin-17 receptor antagonist reduces inflammatory response in experimental periodontitis
International Dental Journal, 2023 Aim or Purpose: Interleukin (IL)-17 is one of the inflammatory cytokines caused periodontitis and psoriasis. Psoriasis, a chronic inflammatory skin disease, treats with IL-17 receptor antagonist (brodalumab: BRD). However, little is known about the effect of BRD on periodontitis.
Dr Takenori Sato, Dr. Keisuke Handa
openaire +2 more sources