Results 51 to 60 of about 442,994 (306)
Interleukin-17A: The Key Cytokine in Neurodegenerative Diseases
Frontiers in Aging Neuroscience, 2020 Neurodegenerative diseases are characterized by the loss of neurons and/or myelin sheath, which deteriorate over time and cause dysfunction. Interleukin 17A is the signature cytokine of a subset of CD4+ helper T cells known as Th17 cells, and the IL-17 ...
Junjue Chen, Xiaohong Liu, Yisheng Zhong
doaj +1 more source
Emerging targets in human lymphoma: targeting the MYD88 mutation [PDF]
, 2016 B cell neoplasms co-opt the molecular machinery of normal B cells for their survival. Technological advances in cancer genomics has significantly contributed to uncovering the root cause of aggressive lymphomas, revealing a previously unknown link ...
Horikawa, Keisuke +2 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider +4 more
wiley +1 more source
Il-15/il-15rα signalling and synaptic transmission: a crosstalk between the immune and the nervous system? [PDF]
, 2019 Immune and nervous system have been traditionally considered separately, but from ‘90s many studies had unraveled the deep interconnection and interdependence between these two systems, enough to coin the term “neuroimmune system” to define this ...
Carbonari, Laura
core
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley +1 more source
Ligand induced cleavage and nuclear localization of the rice XA21 immune receptor [PDF]
, 2012 The rice XA21 receptor confers immunity to the Gram-negative bacterial pathogen, _Xanthomonas oryzae_ pv. _oryzae_ (_Xoo_) upon recognition of the conserved microbial signature AxY^S^22.
Chang-Jin Park, Pamela C. Ronald
core +1 more source
The gut-brain axis, BDNF, NMDA and CNS disorders [PDF]
, 2016 Gastro-intestinal (GI) microbiota and the ‘gut-brain axis’ are proving to be increasingly relevant to early brain development and the emergence of psychiatric disorders.
Maqsood, Raeesah, Stone, Trevor W.
core +1 more source
Critical Role of the Interleukin-17/Interleukin-17 Receptor Axis in Regulating Host Susceptibility to Respiratory Infection withChlamydiaSpecies [PDF]
Infection and Immunity, 2009 ABSTRACTThe specific contribution of interleukin-17/interleukin-17 receptor (IL-17/IL-17R)-mediated responses in regulating host susceptibility against obligatory intracellularChlamydiainfection was investigated in C57BL/6 and C3H/HeN mice duringChlamydia muridarumrespiratory infection.
Xiaohui, Zhou +5 more
openaire +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Interleukin-17/Interleukin-17 Receptor-Mediated Signaling Is Important for Generation of an Optimal Polymorphonuclear Response againstToxoplasma gondiiInfection [PDF]
Infection and Immunity, 2005 ABSTRACTWe investigated the role of interleukin-17 (IL-17)/IL-17 receptor (IL-17R)-mediated signaling in the protective immunity againstToxoplasma gondii. IL-17R−/−mice developed a normal adaptive immunity against the parasite. However, increased mortality in the knockout animals can be attributed to a defect in the migration of polymorphonuclear ...
Michelle N, Kelly +7 more
openaire +2 more sources