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Genomics and Variation of Ionotropic Glutamate Receptors
Annals of the New York Academy of Sciences, 2003Abstract: Sequencing of the human, mouse, and rat genomes has enabled a comprehensive informatics approach to gene families. This approach is informative for identification of new members of gene families, for cross‐species sequence conservation related to functional conservation, for within‐species diversity related to functional variation, and for ...
Robert H, Lipsky, David, Goldman
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Facilitation of glutamate release by ionotropic glutamate receptors in osteoblasts
Biochemical and Biophysical Research Communications, 2002Constitutive expression of mRNA was seen for the vesicular glutamate transporter brain-specific Na(+)-dependent inorganic phosphate cotransporter (BNPI), but not differentiation-associated Na(+)-dependent inorganic phosphate cotransporter, in rat calvarial osteoblasts cultured for 7 and 21 days in vitro (DIV).
Eiichi, Hinoi +4 more
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Computational Approaches to Ionotropic Glutamate Receptors
2010Ionotropic glutamate receptors (iGluRs) mediate the majority of fast neurotransmission in the brain. They are tetrameric proteins that upon the binding of glutamate allow the passage of cations into or out of the cell. This flow of ions changes the transmembrane potential in that region of the cell membrane and is the physical basis for signal ...
Vijayan, R., Iorga, B., C. Biggin, P.
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Ionotropic Glutamate Receptors
1997Glutamate is the major mediator of fast excitatory transmission in the mammalian central nervous system (CNS). It plays an important role in processes controlling synaptic plasticity, memory formation, and learning. The release of excess glutamate and overexcitation are the causes of neuronal damage and cell death in pathological conditions, such as ...
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Ionotropic Glutamate Receptor Recognition and Activation
2004Ionotropic glutamate receptors are the major excitatory neurotransmitters in mammalian brain but are found throughout the animal kingdom as well as in plants and bacteria. A great deal of progress in understanding the structure of these essential neurotransmitter receptors has been made since the first examples were cloned and sequenced in 1989.
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Emerging insights into the structure and function of ionotropic glutamate delta receptors
British Journal of Pharmacology, 2022Ananth Prasad Burada +2 more
exaly
Structure of Ionotropic Glutamate Receptors
1999By 1987, all of the major ligand-gated ion-channel families had succumbed to cloning efforts, with one notable exception, the glutamate receptors. Acetylcholine receptors had been cloned first, aided by the fact that these proteins bind α-bungarotoxin with high specificity and affinity, and that they are highly concentrated in the muscle tissue of the ...
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Ionotropic glutamate receptors in astrocytes
2001G, Seifert, C, Steinhäuser
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Ionotropic Glutamate Receptors in the CNS
1999Section I: Molecula r Structure of Glutamate Receptors.- 1 Structure of Ionotropic Glutamate Receptors.- 2 Phosphorylation of Glutamate Receptors.- 3 The Synaptic Protein Network Associated with Ionotropic Glutamate Receptors.- 4 Cellular and Subcellular Distribution of Glutamate Receptors.- Section II: Functional Properties of Glutamate Receptors.- 5 ...
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