Results 181 to 190 of about 44,977 (226)

Ionotropic Glutamate Receptors

2013
On this planet, the mammalian brain is probably the most complex cellular network. In this system, glutamate is the dominant neurotransmitter, and it mediates the fast communication between the units of the network. Glutamate's main sites of action are the ionotropic glutamate receptors (iGluRs) and G−protein−coupled metabotropic glutamate receptors ...
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Modulation of Ionotropic Glutamate Receptor Channels

Neurochemical Research, 2001
Glutamate is the major excitatory neurotransmitter in the brain. It acts at ligand-gated cationic channels (NMDA, AMPA and kainate receptors) and at G protein-coupled metabotropic glutamate receptors as well. The glutamatergic transmission is suggested to be involved in development, learning and memory.
L, Köles, K, Wirkner, P, Illes
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Ionotropic Glutamate Receptors

1997
Glutamate is the major mediator of fast excitatory transmission in the mammalian central nervous system (CNS). It plays an important role in processes controlling synaptic plasticity, memory formation, and learning. The release of excess glutamate and overexcitation are the causes of neuronal damage and cell death in pathological conditions, such as ...
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Structural dynamics of an ionotropic glutamate receptor

Proteins: Structure, Function, and Bioinformatics, 2004
AbstractIonotropic glutamate receptors (iGluRs) are postsynaptic ion channels involved in excitatory neurotransmission. iGluRs play important roles in development and in forms of synaptic plasticity that underlie higher order processes such as learning and memory. Neurobiological and biochemical studies have long characterized iGluRs in detail. However,
Minoru, Kubo, Etsuro, Ito
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Linking tricyclic antidepressants to ionotropic glutamate receptors

Biochemical and Biophysical Research Communications, 2005
Although tricyclic antidepressants have been in existence since the 1940s when they were discovered upon screening iminodibenzyl derivatives for other potential therapeutic uses, their mechanism of action has remained unclear [A. Goodman Gilman, T.W. Rall, A.S. Nies, P. Taylor, Goodman and Gilman's The Pharmacological Basis of Therapeutics, eighth ed.,
Laura, Stoll, Lisa, Gentile
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Ionotropic glutamate receptors made crystal clear

Trends in Neurosciences, 2014
Two recent crystallographic studies of the full-length GluA2 AMPA receptor provide our first insights into how the modular domains of the tetrameric complex coordinate the process of activation. These findings herald a new era in the structure-function analyses of neurotransmitter receptors, a fitting achievement for the 'International Year of ...
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Computational Approaches to Ionotropic Glutamate Receptors

2010
Ionotropic glutamate receptors (iGluRs) mediate the majority of fast neurotransmission in the brain. They are tetrameric proteins that upon the binding of glutamate allow the passage of cations into or out of the cell. This flow of ions changes the transmembrane potential in that region of the cell membrane and is the physical basis for signal ...
Vijayan, R., Iorga, B., C. Biggin, P.
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Ionotropic Glutamate Receptor Recognition and Activation

2004
Ionotropic glutamate receptors are the major excitatory neurotransmitters in mammalian brain but are found throughout the animal kingdom as well as in plants and bacteria. A great deal of progress in understanding the structure of these essential neurotransmitter receptors has been made since the first examples were cloned and sequenced in 1989.
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Ionotropic Glutamate Receptors in Spinal Nociceptive Processing

Molecular Neurobiology, 2009
Glutamate is the predominant excitatory transmitter used by primary afferent synapses and intrinsic neurons in the spinal cord dorsal horn. Accordingly, ionotropic glutamate receptors mediate basal spinal transmission of sensory, including nociceptive, information that is relayed to supraspinal centers.
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Structure of Ionotropic Glutamate Receptors

1999
By 1987, all of the major ligand-gated ion-channel families had succumbed to cloning efforts, with one notable exception, the glutamate receptors. Acetylcholine receptors had been cloned first, aided by the fact that these proteins bind α-bungarotoxin with high specificity and affinity, and that they are highly concentrated in the muscle tissue of the ...
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