Results 191 to 200 of about 644,252 (236)

Molecular Structure of Ionotropic Glutamate Receptors

Current Medicinal Chemistry, 2010
L-glutamate is the major excitatory neurotransmitter in the central nervous system (CNS). Although just a few glutamate receptor ligands have turned out to be clinically useful, primarily because of unfavorable psychotropic side effects, the glutamate system remains an attractive molecular target in the treatment of epilepsy, neurodegenerative diseases
A A, Kaczor, D, Matosiuk
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Glycine agonism in ionotropic glutamate receptors

Neuropharmacology, 2021
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate the majority of excitatory neurotransmission in the vertebrate CNS. Classified as AMPA, kainate, delta and NMDA receptors, iGluRs are central drivers of synaptic plasticity widely considered as a major cellular substrate of learning and memory. Surprisingly however, five
Stroebel, David, Mony, Laetitia, Paoletti, Pierre   +2 more
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Structural dynamics of an ionotropic glutamate receptor

Proteins: Structure, Function, and Bioinformatics, 2004
AbstractIonotropic glutamate receptors (iGluRs) are postsynaptic ion channels involved in excitatory neurotransmission. iGluRs play important roles in development and in forms of synaptic plasticity that underlie higher order processes such as learning and memory. Neurobiological and biochemical studies have long characterized iGluRs in detail. However,
Minoru, Kubo, Etsuro, Ito
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Modulation of Ionotropic Glutamate Receptor Channels

Neurochemical Research, 2001
Glutamate is the major excitatory neurotransmitter in the brain. It acts at ligand-gated cationic channels (NMDA, AMPA and kainate receptors) and at G protein-coupled metabotropic glutamate receptors as well. The glutamatergic transmission is suggested to be involved in development, learning and memory.
L, Köles, K, Wirkner, P, Illes
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Genomics and Variation of Ionotropic Glutamate Receptors

Annals of the New York Academy of Sciences, 2003
Abstract: Sequencing of the human, mouse, and rat genomes has enabled a comprehensive informatics approach to gene families. This approach is informative for identification of new members of gene families, for cross‐species sequence conservation related to functional conservation, for within‐species diversity related to functional variation, and for ...
Robert H, Lipsky, David, Goldman
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Facilitation of glutamate release by ionotropic glutamate receptors in osteoblasts

Biochemical and Biophysical Research Communications, 2002
Constitutive expression of mRNA was seen for the vesicular glutamate transporter brain-specific Na(+)-dependent inorganic phosphate cotransporter (BNPI), but not differentiation-associated Na(+)-dependent inorganic phosphate cotransporter, in rat calvarial osteoblasts cultured for 7 and 21 days in vitro (DIV).
Eiichi, Hinoi, Sayumi, Fujimori, Takeshi, Takarada, Hideo, Taniura, Yukio, Yoneda   +4 more
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Computational Approaches to Ionotropic Glutamate Receptors

2010
Ionotropic glutamate receptors (iGluRs) mediate the majority of fast neurotransmission in the brain. They are tetrameric proteins that upon the binding of glutamate allow the passage of cations into or out of the cell. This flow of ions changes the transmembrane potential in that region of the cell membrane and is the physical basis for signal ...
Vijayan, R., Iorga, B., C. Biggin, P.
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Ionotropic Glutamate Receptors

1997
Glutamate is the major mediator of fast excitatory transmission in the mammalian central nervous system (CNS). It plays an important role in processes controlling synaptic plasticity, memory formation, and learning. The release of excess glutamate and overexcitation are the causes of neuronal damage and cell death in pathological conditions, such as ...
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Neuroprotective potential of ionotropic glutamate receptor antagonists

Neurotoxicity Research, 2002
From the therapeutic point of view, the real challenge is not only to improve the symptoms, but to interfere with the pathomechanism of the disease. That is why a considerable interest has recently been devoted to developing glutamate receptor antagonists (mainly of the NMDA type) for acute and chronic neurodegeneration.
Wojciech, Danysz, Chris G, Parsons
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Ionotropic Glutamate Receptor Recognition and Activation

2004
Ionotropic glutamate receptors are the major excitatory neurotransmitters in mammalian brain but are found throughout the animal kingdom as well as in plants and bacteria. A great deal of progress in understanding the structure of these essential neurotransmitter receptors has been made since the first examples were cloned and sequenced in 1989.
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