Results 51 to 60 of about 44,977 (226)

Synchrotron XRF Imaging Reveals Manganese Accumulation in the Golgi and Post‐Synapses of Neurons and Enhanced Uptake in Astrocytes

Advanced Science, EarlyView.
Despite widespread exposure, the mechanisms of manganese neurotoxicity remain poorly understood. Using correlative cryogenic fluorescence and synchrotron X‐ray fluorescence imaging techniques, we show that the Golgi apparatus is the primary accumulation site for manganese in both neurons and astrocytes, and that manganese targets the neuronal ...
Ines Kelkoul, Aiyarin Kittilukkana, Luis C. C. Huarte, Hiram Castillo‐Michel, Murielle Salome, Stéphane Roudeau, Pauline Belzanne, Matthieu Sainlos, Noémie Pied, Monica Fernandez‐Monreal, Daniel Choquet, Richard Ortega, Asuncion Carmona   +12 more
wiley   +1 more source

Excess glutamate release triggers subunit-specific homeostatic receptor scaling

Cell Reports, 2023
Summary: Ionotropic glutamate receptors (GluRs) are targets for modulation in Hebbian and homeostatic synaptic plasticity and are remodeled by development, experience, and disease.
Yifu Han, Pragya Goel, Jiawen Chen, Sarah Perry, Nancy Tran, Samantha Nishimura, Manisha Sanjani, Chun Chien, Dion Dickman   +8 more
doaj   +1 more source

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

Presynaptic adenosine receptor-mediated regulation of diverse thalamocortical short-term plasticity in the mouse whisker pathway [PDF]

, 2016
Short-term synaptic plasticity (STP) sets the sensitivity of a synapse to incoming activity and determines the temporal patterns that it best transmits.
Abbott, Agmon, Ariel, Armbruster, Baden, Bale, Beck, Beierlein, Blackman, Borgdorff, Boudreau, Branco, Branco, Bruno, Buonomano, Calloway, Carvalho, Castro-Alamancos, Castro-Alamancos, Chabrol, Cheetham, Chung, Covic, Crair, Cruikshank, Crunelli, David, Daw, de Jong, Dudek, Dunwiddie, Díaz-Quesada, Díaz-Quesada, Elmslie, Ermolyuk, Fioravante, Fioravante, Fontanez, Fortune, Francisco J. Martini, Gabernet, Gil, Gil, Giovanni Ferrati, Heiss, Hennig, Higley, Jouhanneau, Kandaswamy, Kerr, Kidd, Körber, Leal, Lee, Lee, Lerma, Lupica, McCormick, McCormick, Miguel Maravall, Mochida, Moore, Mulle, Mulle, Müller, Nicoll, Ollerenshaw, Pfister, Pologruto, Porter, Poulet, Reig, Ribrault, Rose, Scanziani, Shen, Sherman, Sippy, Slézia, Stratford, Sun, Sylwestrak, Urbain, Urbano, Viaene, Welzel, Wilent, Wu, Yang, Zhao, Zucker   +90 more
core   +2 more sources

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

Orchestrating the metastatic symphony: the role of extracellular vesicles in the epithelial–mesenchymal transition and pulmonary niche formation of breast cancer

Biological Reviews, EarlyView.
ABSTRACT The complexity of breast cancer (BC) lung metastasis lies in the capacity of tumour cells to interact efficiently with distant organs to promote colonisation, a process that involves the sophisticated coordination of inherent cellular plasticity and the remodelling of the distant microenvironment.
Jian Lu, Reza Shirazi Nia, Junjie Sun, Chrysa Filippopoulou, Daniel De Vega, Pengtao Hu, Heng Liang, Hang Yao, Chaoyue Pan, Xiaoyan Wu, Xidong Gu, Xiaohong Xie, Georgios Giamas   +12 more
wiley   +1 more source

Allosteric modulation of retinal GABA receptors by ascorbic acid [PDF]

, 2011
Ionotropic GABA receptors (GABAA and GABAC) belong to the Cys-loop receptor family of ligand-gated ion channels. GABAC receptors are highly expressed in the retina, mainly localized at the axon terminals of bipolar cells.
Aguayo, Luis G., Calero, Cecilia Ines, Calvo, Daniel Juan, Cid, Gustavo Moraga, Vickers, Evan, von Gersdorff, Henrique   +5 more
core   +1 more source

In Vivo Cytoskeletal AMPA Receptor Transport Imaging in C. elegans

Cytoskeleton, EarlyView.
ABSTRACT Long‐distance intracellular transport of ionotropic glutamate receptors (iGluRs) is essential for proper excitatory synaptic function underlying learning and memory. Many neuropsychiatric and neurodegenerative conditions have abnormal iGluR transport and trafficking, leading to an intense interest in the mechanisms and factors regulating these
Michaelis A. K., Hoerndli F. J.
wiley   +1 more source

Ionotropic glutamate receptor AMPA 1 is associated with ovulation rate.

PLoS ONE, 2010
Ionotropic glutamate receptors mediate most excitatory neurotransmission in the central nervous system by opening ion channels upon the binding of glutamate.
Mayumi Sugimoto, Shinji Sasaki, Toshio Watanabe, Shota Nishimura, Atsushi Ideta, Maya Yamazaki, Keiko Matsuda, Michisuke Yuzaki, Kenji Sakimura, Yoshito Aoyagi, Yoshikazu Sugimoto   +10 more
doaj   +1 more source

Chimeric glutamate receptor subunits reveal the transmembrane domain is sufficient for NMDA receptor pore properties but some positive allosteric modulators require additional domains [PDF]

, 2016
NMDA receptors are ligand-gated ion channels that underlie transmission at excitatory synapses and play an important role in regulating synaptic strength and stability.
Huettner, Jmaes E, Lopez, Melany N, Wilding, Timothy J   +2 more
core   +2 more sources