Results 61 to 70 of about 25,770 (191)

Ionotropic Glutamate Receptors & CNS Disorders [PDF]

CNS & Neurological Disorders - Drug Targets, 2008
Disorders of the central nervous system (CNS) are complex disease states that represent a major challenge for modern medicine. Although aetilogy is often unknown, it is established that multiple factors such as defects in genetics and/or epigenetics, the environment as well as imbalance in neurotransmitter receptor systems are all at play in ...
openaire   +2 more sources

Posttranslational Modification Biology of Glutamate Receptors and Drug Addiction

Frontiers in Neuroanatomy, 2011
Posttranslational covalent modifications of glutamate receptors remain a hot topic. Early studies have established that this family of receptors, including almost all ionotropic and metabotropic glutamate receptor subtypes, undergoes active ...
Li-Min eMao, Ming-Lei eGuo, Dao-Zhong eJin, Eugene E Fibuch, Eun Sang eChoe, John Q Wang   +5 more
doaj   +1 more source

Organization of Astrocytic GLT‐1 at Cortical Inhibitory Synapses

Glia, Volume 74, Issue 8, August 2026.
GLT‐1+ ALs frequently juxtapose symmetric synapses. Distance‐based phenotyping identifies symmetric‐ and asymmetric‐associated GLT‐1+ ALs. Distal inhibitory synapses show enriched GLT‐1/α2 couples in ALs within 1000 nm, conserved in human cortex. ABSTRACT Glutamate spillover from excitatory synapses modulates neighboring inhibitory synapses, yet the ...
Marcello Melone, Michael Di Palma, Annalisa Scimemi, Fiorenzo Conti   +3 more
wiley   +1 more source

Mechanisms of glutamate metabolic function and dysfunction in vascular dementia

Neuroprotection
As the global population ages, research on the pathogenesis and treatment options for older patients with dementia has become increasingly important.
Jiawen Wang, Yingmei Zhang, Ning Tian, Dongshan Ya, Jiaxin Yang, Yanlin Jiang, Xiaoxia Li, Xiaohui Lin, Bin Yang, Qinghua Li, Rujia Liao   +10 more
doaj   +1 more source

Neurodevelopmental Consequences Induced by Early‐Life Lead Exposure Through Disruption of Neurotransmitter Pathways and Molecular Mechanisms: A Systematic Review

Developmental Neurobiology, Volume 86, Issue 3, July 2026.
ABSTRACT Lead is a toxic heavy metal with significant health risks, as maternal lead exposure during pregnancy disrupts fetal neural development through placental transfer, leading to persistent neurological, developmental, and long‐term health consequences in the progeny.
P. Harshitha, Aluru Parithathvi, Kamalesh Dattaram Mumbrekar, Herman Sunil Dsouza   +3 more
wiley   +1 more source

Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains

Nature Communications, 2017
The dopamine transporter (DAT) has a crucial role in the regulation of neurotransmission. Here, the authors use super-resolution imaging to show that DAT clusters into cholesterol-dependent membrane regions that are reversibly regulated by ionotropic ...
Troels Rahbek-Clemmensen, Matthew D. Lycas, Simon Erlendsson, Jacob Eriksen, Mia Apuschkin, Frederik Vilhardt, Trine N. Jørgensen, Freja H. Hansen, Ulrik Gether   +8 more
doaj   +1 more source

Relationship Between Central Sensitization and Genetic Polymorphisms—A Case–Control Study in Fibromyalgia

European Journal of Pain, Volume 30, Issue 6, July 2026.
ABSTRACT Background Fibromyalgia is a syndrome characterised by widespread chronic pain, which is believed to be mediated by a state of central sensitisation (CS). Based on the hypothesis that CS itself could have genetic determinants, our aim was to further explore this pathway.
Nicolas Macian, Christian Dualé, Marine Delay, Vincent Leray, Bruno Pereira, Yoan Renaud, Yvonne Gloor, Jules Desmeules, Gisèle Pickering   +8 more
wiley   +1 more source

Apple Pomace Pectin for Gastroprotective Nutraceutical Delivery: Structure–Function Relationships and Nano/Microencapsulation Strategies for Gastric Ulcer Management

Food Frontiers, Volume 7, Issue 4, July 2026.
Apple pomace pectin is explored as a sustainable and multifunctional biomaterial for gastric ulcer management. Its unique structural features confer mucoadhesive, anti‐inflammatory, antioxidant, and anti‐Helicobacter pylori activities while enabling nano/microencapsulation of therapeutic agents.
Akash Dhiman, Shefali Arora, Parteek Prasher, Sukanya Chhetri, Pankaj Bhandari, William N. Setzer, Javad Sharifi‐Rad   +6 more
wiley   +1 more source

Are FXR Family Proteins Integrators of Dopamine Signaling and Glutamatergic Neurotransmission in Mental Illnesses?

Frontiers in Synaptic Neuroscience, 2018
Dopamine receptors and related signaling pathways have long been implicated in pathophysiology and treatment of mental illnesses, including schizophrenia and bipolar disorder.
Jivan Khlghatyan, Jivan Khlghatyan, Jean-Martin Beaulieu, Jean-Martin Beaulieu   +3 more
doaj   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source