Results 81 to 90 of about 25,770 (191)

The diversity of AMPA receptor inhibition mechanisms among amidine-containing compounds

Frontiers in Pharmacology
Amidine-containing compounds are primarily known as antiprotozoal agents (pentamidine, diminazene, furamidine) or as serine protease inhibitors (nafamostat, sepimostat, camostat, gabexate). DAPI is widely recognized as a fluorescent DNA stain.
Arseniy S. Zhigulin, Mikhail Y. Dron, Oleg I. Barygin, Denis B. Tikhonov   +3 more
doaj   +1 more source

Calcium Buffering in Astrocytes and Its Relevance for Experimental Data Interpretation and Computational Modeling

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
Components and properties of Ca2+ buffers in astrocytes, which should be considered for data interpretation and in computational modeling of astrocyte Ca2+ activity. ABSTRACT Astrocytic Ca2+ signaling is essential for maintaining physiological brain function, including the modulation of synaptic transmission, neurovascular coupling, and ion homeostasis.
Kerstin Lenk, Andre Zeug, Franziska E. Müller   +2 more
wiley   +1 more source

Regulation of Ionotropic Glutamate Receptors by Their Auxiliary Subunits [PDF]

Physiology, 2010
Glutamate receptors are major excitatory receptors in the brain. Recent findings have established auxiliary subunits of glutamate receptors as critical modulators of synaptic transmission, synaptic plasticity, and neurological disorder. The elucidation of the molecular rules governing glutamate receptors and subunits will improve our understanding of ...
openaire   +2 more sources

Glutamate Receptor Signaling in Retina Müller Cells: Plausible Role in Neurodegeneration

Receptors
The retinal network relies on glutamate, the primary excitatory neurotransmitter involved in the visual cycle. Glutamate transactions are carried out by an array of distinct receptors and transporters distributed across both pre- and post-synaptic ...
Bolaji Oyetayo, Yurixy Mendoza-Silva, Temitayo Subair, Luisa C Hernández-Kelly, Marie-Paule Felder-Schmittbuhl, Tatiana N. Olivares-Bañuelos, Arturo Ortega   +6 more
doaj   +1 more source

Glutamate signalling in bone.

Frontiers in Endocrinology, 2012
Mechanical loading plays a key role in the physiology of bone, allowing bone to functionally adapt to its environment, however characterisation of the signalling events linking load to bone formation is incomplete.
Karen eBrakspear, Deborah eMason
doaj   +1 more source

Ischemia‐Induced Post‐Translational Modifications of GLT‐1 Mediate Aberrant Trafficking and Impaired Glutamate Uptake

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
Ischemic insult causes hyper‐glutamatergic signaling and neuronal death. The astrocytic transporter GLT‐1, which clears extracellular glutamate, is internalized and degraded in response to ischemia. We found that lysine‐directed post‐translational modifications (particularly ubiquitination) of the C‐terminal domain drive aberrant trafficking ...
Simran Kaur Gill, Katelyn Louise Reeb, Max Kroll, Ole V. Mortensen, Andréia C. K. Fontana   +4 more
wiley   +1 more source

Distinct combinations of variant ionotropic glutamate receptors mediate thermosensation and hygrosensation in Drosophila

eLife, 2016
Ionotropic Receptors (IRs) are a large subfamily of variant ionotropic glutamate receptors present across Protostomia. While these receptors are most extensively studied for their roles in chemosensory detection, recent work has implicated two family ...
Zachary A Knecht, Ana F Silbering, Lina Ni, Mason Klein, Gonzalo Budelli, Rati Bell, Liliane Abuin, Anggie J Ferrer, Aravinthan DT Samuel, Richard Benton, Paul A Garrity   +10 more
doaj   +1 more source

NMDA and glycine receptors provide dual presynaptic regulation on climbing fibre inputs to cerebellar Purkinje cells

The Journal of Physiology, Volume 604, Issue 12, Page 4926-4944, 15 June 2026.
Abstract figure legend Vibrodissociated Pukinje neurons retain active synaptic connections, including those from adhering fragments of the climbing fibre. These fragments generate excitatory synaptic events and the frequency of these events is increased by exposure to either NMDA [with d‐serine (d‐ser) as a co‐agonist] or glycine at a high (100 µM ...
David C. H. Benton, Alan D. Robertson, Matthew Caldwell, Yuriy Pankratov, Lema Imam, Trevor G. Smart, Gareth Morris, Guy W. J. Moss   +7 more
wiley   +1 more source

An expression atlas of variant ionotropic glutamate receptors identifies a molecular basis of carbonation sensing

Nature Communications, 2018
Little is known about the role of variant ionotropic glutamate receptors (IRs) in insect taste. Here the authors characterise the expression pattern of IRs in the Drosophila gustatory system and highlight the role of one receptor, IR56d, in the detection
Juan Antonio Sánchez-Alcañiz, Ana Florencia Silbering, Vincent Croset, Giovanna Zappia, Anantha Krishna Sivasubramaniam, Liliane Abuin, Saumya Yashmohini Sahai, Daniel Münch, Kathrin Steck, Thomas O. Auer, Steeve Cruchet, G. Larisa Neagu-Maier, Simon G. Sprecher, Carlos Ribeiro, Nilay Yapici, Richard Benton   +15 more
doaj   +1 more source

Memantine inhibits calcium-permeable AMPA receptors

Nature Communications
Memantine is an US Food and Drug Administration (FDA) approved drug that is thought to selectively inhibit NMDA-subtype of ionotropic glutamate receptors (NMDARs).
Elisa Carrillo, Alejandra Montaño Romero, Cuauhtemoc U. Gonzalez, Andreea L. Turcu, Santiago Vázquez, Edward C. Twomey, Vasanthi Jayaraman   +6 more
doaj   +1 more source