Results 31 to 40 of about 644,252 (236)

Ionotropic glutamate receptors (iGluRs) of the delta family (GluD1 and GluD2) and synaptogenesis

Alexandria Journal of Medicine, 2017
Glutamate delta-1 (GluD1) and glutamate delta-2 (GluD2) form the delta family of ionotropic glutamate receptors (iGluRs) and are distinct from other (iGluRs) in that they do not exhibit typical agonist-induced ion channel currents.
Muhammad Zahid Khan
doaj   +1 more source

Ultrasound modulates neuronal potassium currents via ionotropic glutamate receptors

Brain Stimulation, 2023
Background: Focused ultrasound stimulation (FUS) has the potential to provide non-invasive neuromodulation of deep brain regions with unparalleled spatial precision.
Benjamin Clennell, Tom G.J. Steward, Kaliya Hanman, Tom Needham, Janette Benachour, Mark Jepson, Meg Elley, Nathan Halford, Kate Heesom, Eunju Shin, Elek Molnár, Bruce W. Drinkwater, Daniel J. Whitcomb   +12 more
doaj   +1 more source

More than meets the IR: the expanding roles of variant Ionotropic Glutamate Receptors in sensing odor, taste, temperature and moisture [version 1; referees: 2 approved]

F1000Research, 2017
The ionotropic receptors (IRs) are a branch of the ionotropic glutamate receptor family and serve as important mediators of sensory transduction in invertebrates.
Lena van Giesen, Paul A. Garrity
doaj   +1 more source

Glutamatergic Mechanisms in Glioblastoma and Tumor-Associated Epilepsy

Cells, 2021
The progression of glioblastomas is associated with a variety of neurological impairments, such as tumor-related epileptic seizures. Seizures are not only a common comorbidity of glioblastoma but often an initial clinical symptom of this cancer entity ...
Falko Lange, Max Frederik Hörnschemeyer, Timo Kirschstein   +2 more
doaj   +1 more source

Group 1 metabotropic glutamate receptor function and its regulation of learning and memory in the aging brain

Frontiers in Pharmacology, 2012
Normal aging is generally characterized by a slow decline of cognitive abilities albeit with marked individual differences. Several animal models have been studied to explore the molecular and cellular mechanisms underlying this phenomenon.
Caroline eMénard, Rémi eQuirion
doaj   +1 more source

NMDA and AMPA Receptor Autoantibodies in Brain Disorders: From Molecular Mechanisms to Clinical Features

Cells, 2021
The role of autoimmunity in central nervous system (CNS) disorders is rapidly expanding. In the last twenty years, different types of autoantibodies targeting subunits of ionotropic glutamate receptors have been found in a variety of patients affected by
Fabrizio Gardoni, Jennifer Stanic, Diego Scheggia, Alberto Benussi, Barbara Borroni, Monica Di Luca   +5 more
doaj   +1 more source

mGluR1α expression in the hippocampus, subiculum, entorhinal cortex and superior temporal gyrus in Alzheimer’s disease

IBRO Neuroscience Reports, 2022
Glutamate is the main excitatory neurotransmitter in the central nervous system, responsible for a plethora of cellular processes including memory formation and higher cerebral function and has been implicated in various neurological disease states ...
J.H.Y. Yeung, T.H. Palpagama, C. Turner, H.J. Waldvogel, R.L.M. Faull, A. Kwakowsky   +5 more
doaj   +1 more source

Structural Insights into Function of Ionotropic Glutamate Receptors

Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology, 2022
Ionotropic glutamate receptors (iGluRs) mediate fast excitatory neurotransmission. They are implicated in nervous system development and function, while their dysfunction is associated with neurological and psychiatric disorders. In this review, we describe recent progress in structural studies of iGluRs and how crystal and cryo-EM structures helped ...
Yelshanskaya, Maria V., Sobolevsky, Alexander I.   +1 more
openaire   +2 more sources

Tripartite signalling by NMDA receptors

Molecular Brain, 2020
N-methyl-d-aspartate receptors (NMDARs) are excitatory glutamatergic receptors that are fundamental for many neuronal processes, including synaptic plasticity.
Vishaal Rajani, Ameet S. Sengar, Michael W. Salter   +2 more
doaj   +1 more source

Role of glycosylation of ionotropic glutamate receptors in mammalian neurons [PDF]

, 2016
Glutamate is the most abundant excitatory neurotransmitter in the mammalian central nervous system. There are two distinct types of glutamate receptors, ionotropic and metabotropic, present in the mammalian excitatory synapses.
Danačíková, Šárka
core   +1 more source