Results 21 to 30 of about 44,977 (226)

Phased Treatment Strategies for Cerebral Ischemia Based on Glutamate Receptors

Frontiers in Cellular Neuroscience, 2019
Extracellular glutamate accumulation following cerebral ischemia leads to overactivation of glutamate receptors, thereby resulting in intracellular Ca2+ overload and excitotoxic neuronal injury. Multiple attempts have been made to counteract such effects
Yongjun Sun, Yongjun Sun, Xue Feng, Yue Ding, Mengting Li, Jun Yao, Long Wang, Zibin Gao, Zibin Gao   +8 more
doaj   +1 more source

Astaxanthin Protection against Neuronal Excitotoxicity via Glutamate Receptor Inhibition and Improvement of Mitochondrial Function

Marine Drugs, 2022
Excitotoxicity is known to associate with neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Amyotrophic lateral sclerosis and Huntington’s disease, as well as aging, stroke, trauma, ischemia and epilepsy.
Swapna Kannothum Kandy, Madhura Milind Nimonkar, Suravi Sasmita Dash, Bhupesh Mehta, Yogananda S. Markandeya   +4 more
doaj   +1 more source

Neurotoxic Agent-Induced Injury in Neurodegenerative Disease Model: Focus on Involvement of Glutamate Receptors

Frontiers in Molecular Neuroscience, 2018
Glutamate receptors play a crucial role in the central nervous system and are implicated in different brain disorders. They play a significant role in the pathogenesis of neurodegenerative diseases (NDDs) such as Alzheimer’s disease, Parkinson’s disease,
Md. Jakaria, Shin-Young Park, Md. Ezazul Haque, Govindarajan Karthivashan, In-Su Kim, Palanivel Ganesan, Palanivel Ganesan, Dong-Kug Choi, Dong-Kug Choi, Dong-Kug Choi   +9 more
doaj   +1 more source

Assembly Stoichiometry of the GluK2/GluK5 Kainate Receptor Complex

Cell Reports, 2012
Ionotropic glutamate receptors assemble as homo- or heterotetramers. One well-studied heteromeric complex is formed by the kainate receptor subunits GluK2 and GluK5.
Andreas Reiner, Ryan J. Arant, Ehud Y. Isacoff   +2 more
doaj   +1 more source

Insect odorant response sensitivity is tuned by metabotropically autoregulated olfactory receptors. [PDF]

PLoS ONE, 2013
Insects possess one of the most exquisitely sensitive olfactory systems in the animal kingdom, consisting of three different types of chemosensory receptors: ionotropic glutamate-like receptors (IRs), gustatory receptors (GRs) and odorant receptors (ORs).
Merid N Getahun, Shannon B Olsson, Sofia Lavista-Llanos, Bill S Hansson, Dieter Wicher   +4 more
doaj   +1 more source

When, where and how? Focus on neuronal calcium dysfunctions in Alzheimer's Disease. [PDF]

, 2016
Alzheimer\u2019s disease (AD), since its characterization as a precise form of dementia with its own pathological hallmarks, has captured scientists\u2019 attention because of its complexity.
AGOSTINI, MARIO, FASOLATO, CRISTINA
core   +1 more source

Neural Mechanisms of Temporomandibular Joint and Masticatory Muscle Pain: A Possible Role for Peripheral Glutamate Receptor Mechanisms

Pain Research and Management, 2005
The purpose of the present review is to correlate recent knowledge of the role of peripheral ionotropic glutamate receptors in the temporomandibular joint and muscle pain from animal and human experimental pain models with findings in patients.
David K Lam, Barry J Sessle, Brian E Cairns, James W Hu   +3 more
doaj   +1 more source

P2X receptor trafficking in neurons is subunit specific [PDF]

, 2002
P2X receptors within the CNS mediate excitatory synaptic transmission and also act presynaptically to modulate neurotransmitter release. We have studied the targeting and trafficking of P2X4 and P2X2 receptors heterologously expressed in cultured ...
Bobanovic, Laura K, Murrell-Lagnado, Ruth D, Royle, Stephen J   +2 more
core   +3 more sources

Control of cortical neuronal migration by glutamate and GABA

Frontiers in Cellular Neuroscience, 2015
Neuronal migration in the cortex is controlled by the paracrine action of the classical neurotransmitters glutamate and GABA. Glutamate controls radial migration of pyramidal neurons by acting primarily on NMDA receptors and regulates tangential ...
Heiko J Luhmann, Werner eKilb, Atsuo eFukuda   +2 more
doaj   +1 more source

Ultrasound modulates neuronal potassium currents via ionotropic glutamate receptors

Brain Stimulation, 2023
Background: Focused ultrasound stimulation (FUS) has the potential to provide non-invasive neuromodulation of deep brain regions with unparalleled spatial precision.
Benjamin Clennell, Tom G.J. Steward, Kaliya Hanman, Tom Needham, Janette Benachour, Mark Jepson, Meg Elley, Nathan Halford, Kate Heesom, Eunju Shin, Elek Molnár, Bruce W. Drinkwater, Daniel J. Whitcomb   +12 more
doaj   +1 more source