Results 201 to 210 of about 26,234 (229)

Killer Immunoglobulin-Like Receptors (KIRs) Genotypes in a Belgian Population.

Blood, 2004
Abstract KIRs (Killer cell Immunoglobulin-like Receptors) are expressed on NK (Natural Killer) cells and a subpopulation of T lymphocytes namely memory CD8+ T cells. The distribution of KIR genes varies among individuals and populations. These genes are encoded on chromosome 19 (19q13.4).
Melanny Hidajat, Dominik Selleslag, Achiel Van Hoof, Jan Van Droogenbroeck, Johan Billiet, Arnold Criel   +5 more
openaire   +1 more source

Variation Within the Human Killer Cell Immunoglobulin-Like Receptor ( KIR) Gene Family

Critical Reviews™ in Immunology, 2002
The killer cell immunoglobulin-like receptors (KIR) form a family of highly homologous immune receptors that regulate the response of natural killer (NK) cells and some T cells. The genetics of the human KIR family is reviewed in this article.
Makoto, Yawata, Nobuyo, Yawata, Laurent, Abi-Rached, Peter, Parham   +3 more
openaire   +2 more sources

Molecular recognition by Ig-like receptors, KIRs and FcγRs

2001
Structural studies by us and other groups have shown that Killer cell Ig-like receptors (KIRs) and Fcγ receptors (FcγR) have a similar, unique topology (intermediate between I set and C2 set). In order to gain further insight into molecular recognition by these receptors, we have used surface plasmon resonance (SPR) to analyze the kinetic and ...
Katsumi Maenaka, P. Anton van der Merwe, David I. Stuart, Peter Sondermann, E. Yvonne Jones   +4 more
openaire   +1 more source

Killer Cell Immunoglobulin-Like Receptor (KIR) Genotypes in Patients with Recurrent Tonsillitis

Genetic Testing, 2008
This study represents the first report on the distribution of killer cell immunoglobulin-like receptor (KIR) genotype among recurrent tonsillitis patients. We recruited 34 Lebanese pediatric patients diagnosed with recurrent tonsillitis and had their DNA typed using sequence-specific primer technique for the presence of 16 KIR loci.We observed that 25 ...
Mohamad, Bitar, Roy, Khalaf, Wael, Shamseddeen, Nady, El Hajj, Georges, Ibrahim, Layal, Greige, Ghazi, Zaatari, Nabil, Fuleihan, Amira, Sabbagh, Rami, Mahfouz   +9 more
openaire   +3 more sources

Non‐KIR NK cell receptors: Role in transplantation of allogeneic haematopoietic stem cells

International Journal of Immunogenetics, 2020
AbstractNatural killer (NK) cells are of major significance in patients after allogeneic haematopoietic stem cell transplantation (HSCT). They are the first subset of lymphocytes to appear in peripheral blood after transplantation and play an important role in the immune responses against cancer and viral infections.
Katarzyna Bogunia‐Kubik, Piotr Łacina
openaire   +2 more sources

Mismatches In Killer Immunoglobulin Receptor (KIR) Ligands and Inhibitory KIR Receptors Between Donor and Recipients Improve Survival After Non T Cell Depleted Haploidentical Transplantation

Blood, 2013
Abstract Introduction Alloreactivity triggered by interaction of Killer immunoglobulin-like receptors (KIRs) on donor Natural killer (NK) cells and their ligands on recipients plays a role in the graft-versus-tumour effect. Different predictive models have been postulated for measuring alloreactivity:
Mariana Bastos-Oreiro, Javier Anguita, Carolina Martínez-Laperche, Almudena Navarro, Lucía Fernandez, Pascual Balsalobre, Cristina Muñoz, Mi Kwon, Ana Perez, Cristina Pascual, Antonio Perez, Ismael Buno, Jorge Gayoso, Jose Luis Díez   +13 more
openaire   +1 more source

Interactions between GABA-B1 receptors and Kir 3 inwardly rectifying potassium channels

Cellular Signalling, 2006
gamma-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the mammalian brain. It acts via both ionotropic GABA-A and metabotropic GABA-B receptors. We evaluated the interaction of receptors with members of the inwardly rectifying potassium (Kir 3) channel family, which also play an important role in neuronal transmission and ...
Martin, David, Maxime, Richer, Aida M, Mamarbachi, Louis R, Villeneuve, Denis J, Dupré, Terence E, Hebert   +5 more
openaire   +2 more sources

Expression cloning of rat cerebellar adenosine A1 receptor by coupling to Kir channels

NeuroReport, 1997
G protein activation of inwardly rectifying K+ (Kir) channels by heptahelical receptors is an important signaling motif in slow synaptic transmission in the mammalian brain. To isolate candidate receptors responsive to the purine nucleoside adenosine, a cerebellar cDNA library was constructed in the vector pSGEM and transcripts were injected into ...
Pfaff, T., Karschin, A.
openaire   +3 more sources

Killer-cell immunoglobulin-like receptors (KIR) in severe A (H1N1) 2009 influenza infections

Immunogenetics, 2012
Introduction of a novel influenza virus into the human population leads to the occurrence of pandemic events, such as the one caused by pandemic influenza A (H1N1) 2009 virus. The severity of infections caused by this virus in young adults was greater than that observed in patients with seasonal influenza.
Saray, Aranda-Romo, Christian A, Garcia-Sepulveda, Andreu, Comas-García, Fernando, Lovato-Salas, Mariana, Salgado-Bustamante, Alejandro, Gómez-Gómez, Daniel E, Noyola   +6 more
openaire   +2 more sources

NK cell MHC class I specific receptors (KIR): from biology to clinical intervention

Current Opinion in Immunology, 2012
The natural killer (NK) cell effector response towards infected cells or tumoural cells is guided by the integration of activating and inhibitory signals sensed by NK cell surface receptors. Major histocompatibility complex class I specific inhibitory receptors expressed by NK cells have two distinct roles: while allowing self tolerance, they are also ...
Thielens, A., Vivier E., Romagné F
openaire   +3 more sources