Results 191 to 200 of about 26,234 (229)

KIR: Diverse, Rapidly Evolving Receptors of Innate and Adaptive Immunity

Annual Review of Immunology, 2002
KIR genes have evolved in primates to generate a diverse family of receptors with unique structures that enable them to recognize MHC-class I molecules with locus and allele-specificity. Their combinatorial expression creates a repertoire of NK cells that surveys the expression of almost every MHC molecule independently, thus antagonizing the spread of
Carlos, Vilches, Peter, Parham
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Significance of inhibitory maternal killer-cell immunoglobulin-like receptor (KIR) and fetal KIR ligand genotype combinations in placenta related obstetric complications

Journal of Reproductive Immunology, 2021
Some maternal killer-cell immunoglobulin-like receptor (KIR) and fetal KIR ligand genotypes are associated with obstetric complications, such as recurrent miscarriage, fetal growth restriction, preeclampsia, and preterm birth. However, how KIR/KIR ligand genotypes affect these placenta-related obstetric complications has not been fully understood.
Gokcen Orgul, Klara Dalva, Sevim Dalva-Aydemir, Ridvan Goksel Alniacik, Hanife Guler Donmez, Ayse Nur Cakar, Meral Beksac, Mehmet Sinan Beksac   +7 more
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Significance of KIR like natural killer cell receptors in autoimmune disorders

Clinical Immunology, 2020
Killer cell immunoglobulin-like receptors (KIRs), act as the regulators for the cytolytic activity of natural killer and certain T cells by interacting with the HLA class I ligands. KIRs have been shown to contribute to the pathogenesis of several autoimmune diseases. However, their specific roles are still not very clear.
Suraksha, Agrawal, Swayam, Prakash
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Investigation of killer cell immunoglobulin‐like receptor (KIR) gene diversity: KIR2DL2, KIR2DL5 and KIR2DS5

Tissue Antigens, 2008
AbstractHuman killer cell immunoglobulin‐like receptor (KIR) genes are important for restraining natural killer cytotoxicity toward cells with autologous human leukocyte antigen (HLA) while targeting cells lacking or expressing low levels of self‐HLA molecules.
A, Gonzalez, A, Meenagh, C, Sleator, D, Middleton   +3 more
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Receptor-ligand analyses define minimal killer cell Ig-like receptor (KIR) in humans

Immunogenetics, 2006
Interactions between inhibitory killer cell immunoglobulin-like receptors (iKIR) and human leukocyte antigen (HLA) class I molecules regulate natural killer (NK) cell responses to eliminate infected and transformed cells while maintaining tolerance to healthy cells.
Zeying, Du, David W, Gjertson, Elaine F, Reed, Raja, Rajalingam   +3 more
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NK cell receptor gene of the KIR family with two IG domains but highest homology to KIR receptors with three IG domains

Tissue Antigens, 1996
The killer cell inhibitory receptors (KIRs) are surface glycoproteins expressed by natural killer (NK) cells and some T cells. They recognize polymorphic human HLA class I molecules. Two families of KIRs have been identified and named p58 and p70. The p58 family of genes encode type I membrane proteins with two extracellular immunoglobulin (Ig) domains,
A, Selvakumar, U, Steffens, B, Dupont
openaire   +2 more sources

Genetic variation, Fcγ receptors, KIRs and infection: the evolution of autoimmunity

Current Opinion in Immunology, 2010
Recent work has emphasised the marked genetic variability that exists in the Fc receptor locus. This variation can contribute to the risk of autoimmune disease in both mice and humans, but can also have a profound impact on defence against infection.
Marion, Espeli, Heather A, Niederer, James A, Traherne, John, Trowsdale, Kenneth Gc, Smith   +4 more
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Killer cell immunoglobulin-like receptor (KIR) locus profiles in the Tunisian population

Human Immunology, 2015
Killer cell immunoglobulin-like receptors (KIRs) are a family of inhibitory and activatory receptors that are expressed by most natural killer (NK) cells. The KIR gene family is polymorphic: genomic diversity is achieved through differences in gene content and allelic polymorphism.
Bani, Meriem, Seket, Jihen, Kaabi, Houda, Cherif, Ghaya, Chaabane, Manel, Bellali, Hedi, Hmida, Slama   +6 more
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Natural Killer Cell Immunoglobulin-like Receptors (KIR) Genotypes in two Arab Populations: Will KIR become a genetic landmark between nations?

Molecular Biology Reports, 2007
Genotypic profiles of the Natural killer cell Immunoglobulin-like Receptors (KIR) have been reported to vary among different ethnic groups and this study represents a comparative report on its distribution between two Arabic populations in the Middle East: Lebanese and Palestinians.
Khazen, Georges, Rayes, Roni, Bazarbachi, Ali, Sabbagh, Amira, Zaatari, Ghazi, Mahfouz, Rami   +5 more
openaire   +3 more sources

Report from the Eleventh Killer Immunoglobulin‐like Receptor (KIR) Workshop: Novel insights on KIR polymorphism, ligand recognition, expression and function

HLA, 2019
The Eleventh Killer Immunoglobulin‐like Receptor (KIR) Workshop was held in Camogli (Genoa, Italy) in October 2018. This congress brought together 113 participants working on KIR field. Fifty‐eight studies have been presented, the majority of which included unpublished data. Thus, KIR workshop, allowing the meeting of people sharing their knowledge and
Falco, Michela, Sivori, Simona, Meazza, Raffaella, Pende, Daniela   +3 more
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