Results 181 to 190 of about 560,467 (222)

Significance of KIR like natural killer cell receptors in autoimmune disorders

Clinical Immunology, 2020
Killer cell immunoglobulin-like receptors (KIRs), act as the regulators for the cytolytic activity of natural killer and certain T cells by interacting with the HLA class I ligands. KIRs have been shown to contribute to the pathogenesis of several autoimmune diseases. However, their specific roles are still not very clear.
Suraksha, Agrawal, Swayam, Prakash
openaire   +2 more sources

Investigation of killer cell immunoglobulin‐like receptor (KIR) gene diversity: KIR2DL2, KIR2DL5 and KIR2DS5

Tissue Antigens, 2008
AbstractHuman killer cell immunoglobulin‐like receptor (KIR) genes are important for restraining natural killer cytotoxicity toward cells with autologous human leukocyte antigen (HLA) while targeting cells lacking or expressing low levels of self‐HLA molecules.
A, Gonzalez, A, Meenagh, C, Sleator, D, Middleton   +3 more
openaire   +2 more sources

Killer cell immunoglobulin-like receptor (KIR) locus profiles in the Tunisian population

Human Immunology, 2015
Killer cell immunoglobulin-like receptors (KIRs) are a family of inhibitory and activatory receptors that are expressed by most natural killer (NK) cells. The KIR gene family is polymorphic: genomic diversity is achieved through differences in gene content and allelic polymorphism.
Bani, Meriem, Seket, Jihen, Kaabi, Houda, Cherif, Ghaya, Chaabane, Manel, Bellali, Hedi, Hmida, Slama   +6 more
openaire   +6 more sources

KIR genotype distribution among patients with multiple myeloma: Higher prevalence of KIR 2DS4 and KIR 2DS5 genes [PDF]

Meta Gene, 2014
Introduction: Natural killer (NK) cells possess an antitumor activity against multiple myeloma cells proven by the susceptibility of plasmocytes to NK lysis. In the early stage of MM, the killing of MM cells is mediated by natural cytotoxicity receptors (
Rami Mahfouz
exaly   +2 more sources

14th International HLA and Immunogenetics Workshop: Report on KIR receptors and their applications

Tissue Antigens, 2007
AbstractDuring the last few years many laboratories have developed a keen interest in detecting killer immunoglobulin‐like receptor (KIR) receptor genes in various populations, diseases and in stem cell transplantation. At the 14th International Histocompatibility Workshop held in Melbourne in December 2006, many of these laboratories presented their ...
D, Middleton, F T, Christiansen
openaire   +2 more sources

Receptor-ligand analyses define minimal killer cell Ig-like receptor (KIR) in humans

Immunogenetics, 2006
Interactions between inhibitory killer cell immunoglobulin-like receptors (iKIR) and human leukocyte antigen (HLA) class I molecules regulate natural killer (NK) cell responses to eliminate infected and transformed cells while maintaining tolerance to healthy cells.
Zeying, Du, David W, Gjertson, Elaine F, Reed, Raja, Rajalingam   +3 more
openaire   +2 more sources

Significance of inhibitory maternal killer-cell immunoglobulin-like receptor (KIR) and fetal KIR ligand genotype combinations in placenta related obstetric complications

Journal of Reproductive Immunology, 2021
Some maternal killer-cell immunoglobulin-like receptor (KIR) and fetal KIR ligand genotypes are associated with obstetric complications, such as recurrent miscarriage, fetal growth restriction, preeclampsia, and preterm birth. However, how KIR/KIR ligand genotypes affect these placenta-related obstetric complications has not been fully understood.
Gokcen Orgul, Klara Dalva, Sevim Dalva-Aydemir, Ridvan Goksel Alniacik, Hanife Guler Donmez, Ayse Nur Cakar, Meral Beksac, Mehmet Sinan Beksac   +7 more
openaire   +4 more sources

Killer Immunoglobulin-Like Receptors (KIRs) Genotypes in a Belgian Population.

Blood, 2004
Abstract KIRs (Killer cell Immunoglobulin-like Receptors) are expressed on NK (Natural Killer) cells and a subpopulation of T lymphocytes namely memory CD8+ T cells. The distribution of KIR genes varies among individuals and populations. These genes are encoded on chromosome 19 (19q13.4).
Melanny Hidajat, Dominik Selleslag, Achiel Van Hoof, Jan Van Droogenbroeck, Johan Billiet, Arnold Criel   +5 more
openaire   +1 more source

Report from the Eleventh Killer Immunoglobulin‐like Receptor (KIR) Workshop: Novel insights on KIR polymorphism, ligand recognition, expression and function

HLA, 2019
The Eleventh Killer Immunoglobulin‐like Receptor (KIR) Workshop was held in Camogli (Genoa, Italy) in October 2018. This congress brought together 113 participants working on KIR field. Fifty‐eight studies have been presented, the majority of which included unpublished data. Thus, KIR workshop, allowing the meeting of people sharing their knowledge and
Falco, Michela, Sivori, Simona, Meazza, Raffaella, Pende, Daniela   +3 more
openaire   +2 more sources

Molecular recognition by Ig-like receptors, KIRs and FcγRs

2001
Structural studies by us and other groups have shown that Killer cell Ig-like receptors (KIRs) and Fcγ receptors (FcγR) have a similar, unique topology (intermediate between I set and C2 set). In order to gain further insight into molecular recognition by these receptors, we have used surface plasmon resonance (SPR) to analyze the kinetic and ...
Katsumi Maenaka, P. Anton van der Merwe, David I. Stuart, Peter Sondermann, E. Yvonne Jones   +4 more
openaire   +1 more source