Emerging roles of natural killer cell ligands-HLA-E, HLA-F, HLA-G, MICA, and MICB-in <i>in vitro</i> fertilization outcomes. [PDF]
Chaaithanya IK, Rajalingam R.
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Killer cell immunoglobulin-like receptor (KIR) alleles suggested to be associated with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). [PDF]
Ramadan DJ +11 more
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Immunological Causes of Infertility: Diagnostic Perspectives. [PDF]
Kicińska AM, Maksym RB, Szewczyk G.
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Molecular Interactions Between NK Cells and Acute Leukemic Cells: KIR2DL5 Drastically Limits NK Cell Responses. [PDF]
Ferron E +17 more
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Do the expressions of HLA-G and killer cell immunoglobulin-like receptors change in colorectal cancer? [PDF]
Dinçer E +9 more
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The killer cell inhibitory receptors (KIRs) are surface glycoproteins expressed by natural killer (NK) cells and some T cells. They recognize polymorphic human HLA class I molecules. Two families of KIRs have been identified and named p58 and p70. The p58 family of genes encode type I membrane proteins with two extracellular immunoglobulin (Ig) domains,
A, Selvakumar, U, Steffens, B, Dupont
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Genetic variation, Fcγ receptors, KIRs and infection: the evolution of autoimmunity
Current Opinion in Immunology, 2010Recent work has emphasised the marked genetic variability that exists in the Fc receptor locus. This variation can contribute to the risk of autoimmune disease in both mice and humans, but can also have a profound impact on defence against infection.
Marion, Espeli +4 more
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KIR: Diverse, Rapidly Evolving Receptors of Innate and Adaptive Immunity
Annual Review of Immunology, 2002KIR genes have evolved in primates to generate a diverse family of receptors with unique structures that enable them to recognize MHC-class I molecules with locus and allele-specificity. Their combinatorial expression creates a repertoire of NK cells that surveys the expression of almost every MHC molecule independently, thus antagonizing the spread of
Carlos, Vilches, Peter, Parham
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Significance of KIR like natural killer cell receptors in autoimmune disorders
Clinical Immunology, 2020Killer cell immunoglobulin-like receptors (KIRs), act as the regulators for the cytolytic activity of natural killer and certain T cells by interacting with the HLA class I ligands. KIRs have been shown to contribute to the pathogenesis of several autoimmune diseases. However, their specific roles are still not very clear.
Suraksha, Agrawal, Swayam, Prakash
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AbstractHuman killer cell immunoglobulin‐like receptor (KIR) genes are important for restraining natural killer cytotoxicity toward cells with autologous human leukocyte antigen (HLA) while targeting cells lacking or expressing low levels of self‐HLA molecules.
A, Gonzalez +3 more
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