Results 61 to 70 of about 108,912,939 (192)

Hormone therapy (HT) in women with premature ovarian insufficiency or early menopause: Time to think of a new paradigm for healthy aging. A joint FIGO and IMS position paper

International Journal of Gynecology &Obstetrics, Volume 175, Issue 1, Page 26-47, October 2026.
Abstract Premature ovarian insufficiency (POI) and early menopause (EM) affect millions of women worldwide. Compared with normal menopause, they confer a longer duration of estrogen deficiency and are associated not only with a shorter lifespan, but with a reduced healthspan, owing to an increased risk of cardiovascular, skeletal, cognitive and ...
Chiara Benedetto, Suvarna S. Khadilkar, Rossella E. Nappi, Andrea R. Genazzani, Federica Frezet, Laura Cucinella, Hema Divakar, Panagiotis Anagnostis, Nick Panay   +8 more
wiley   +1 more source

Role of Kisspeptin-1 and Growth Differentiation Factor-15 in Iraqi Patients with Metastatic and Non-metastatic Colorectal Cancer

Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 )
Background: Colorectal cancer (CRC) is a leading cause of cancer mortality worldwide. Identifying novel biomarkers is critical for improving diagnosis, prognosis, and treatment strategies. This study investigates the serum levels of kisspeptin-1 (KISS1),
S. Jawad, Z. Ali
semanticscholar   +1 more source

Beyond reproduction: Exploring the Non-Canonical roles of the Kisspeptin System in Diverse Biological Systems

Bionatura, 2023
G protein-coupled receptors are integral membrane proteins in cell signaling processes. Activation of G protein-coupled receptors by specific agonists promotes the activation of different G-proteins, activating different intracellular signaling pathways,
D. Y. Rodríguez Sarmiento
semanticscholar   +1 more source

Human biomarker navigator

iMeta, Volume 5, Issue 5, October 2026.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

7869 Conditional deletion of androgen receptors from kisspeptin neurons only partially rescues the reproductive phenotype of a prenatal androgen-induced mouse model of polycystic ovary syndrome

Journal of the Endocrine Society
Disclosure: A.G. Novak: None. A.V. Petriv: None. D.B. Lohr: None. K.M. Dillon: None. N.T. Neifert: None. A.M. Moore: None. Polycystic ovary syndrome (PCOS) is a prevalent cause of infertility in people with ovaries of reproductive age.
A. G. Novak, A. Petriv, Dayanara B. Lohr, Kendra M. Dillon, Nicole T. Neifert, Aleisha M. Moore   +5 more
semanticscholar   +1 more source

Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration [PDF]

, 2012
Hyperprolactinemia is the most common cause of hypogonadotropic anovulation and is one of the leading causes of infertility in women aged 25-34. Hyperprolactinemia has been proposed to block ovulation through inhibition of GnRH release.
Justine Bouilly, Javier Tello, Sonigo, Charlotte, Young, Jacques, Millar, Robert, Nadège Carré, Tolle, Virginie, Binart, Nadine, Fabian-Jesus Simony-Conesa, Robert Millar, Millar, Robert P., Bouilly, Justine, Tello, Javier, Alain Caraty, Charlotte Sonigo, Tello, Javier A., Virginie Tolle, Carré, Nadège, Simony-Conesa, Fabian-Jesus, Nadine Binart, Jacques Young, Caraty, Alain, Tello, Javier; id_orcid   +22 more
core   +1 more source

Kisspeptin: A Potential Therapathic Target in Patients with Unexplained Infertility?

, 2021
Kisspeptin has recently emerged as a key regulator of the reproductive axis in women. Kisspeptin, acting centrally via the kisspeptin receptor, stimulates secretion of gonadotrophin releasing hormone (GnRH). Here, we aimed to investigate serum kisspeptin
atakul, N (via Mendeley Data), atakul, nil   +1 more
core   +1 more source

The translational use of Kisspeptin and kisspeptin receptor agonists in humans [PDF]

, 2020
Kisspeptin is a neuropeptide that is known to be a critical regulator of hypothalamic gonadotrophin releasing hormone (GnRH). Physiological studies of kisspeptin have examined the effects of different kisspeptin isoforms (Kisspeptin-10, kisspeptin-54) on
Eng, Pei Chia
core   +1 more source

IMPROVE 2025: The 3rd International Meeting on Pathway‐Related Obesity: Vision & Evidence

Clinical Obesity, Volume 16, Issue 5, October 2026.
ABSTRACT An international cohort of 161 clinicians and researchers from 19 countries attended the 3rd International Meeting on Pathway‐Related Obesity: Vision & Evidence (IMPROVE) in Prague, Czech Republic, on 2–4 July 2025. The aims of the meeting were to advance understanding of hyperphagia and obesity caused by defects in the melanocortin‐4 receptor
Jesús Argente, Erica L. T. van den Akker, Metin Cetiner, Karine Clément, Elizabeth Forsythe, Alastair Garfield, Peter Kühnen, Gabriel Ángel Martos‐Moreno, David Meeker, Hermann L. Müller, Hanneke M. van Santen, Julia von Schnurbein, Bérénice Segrestin, Tomohiro Tanaka, Manuel Tena‐Sempere, Martin Wabitsch, Stefanie Zorn, I. Sadaf Farooqi   +17 more
wiley   +1 more source

Ethanolamine plasmalogens increase luteinising hormone pulsatility and are associated with GPR61 expression in bovine gonadotrophin‐releasing hormone neurons

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Ethanolamine plasmalogens increased LH pulse frequency. GPR61 was expressed in GnRH neurons and gonadotrophs, suggesting a role in neuroendocrine regulation. Ethanolamine plasmalogens (EPls), but not choline plasmalogens (CPls), may act via GPR61 expressed in GnRH neurons in the preoptic area and in anterior pituitary gonadotrophs.
Hiroya Kadokawa, Tomoaki Kubo, Kana Kobayashi, Denis Karani Wanjiru, Yvan Bienvenu Niyonzima   +4 more
wiley   +1 more source