Results 51 to 60 of about 108,912,939 (192)

Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel, Aureliane Pierret, Edouard G. Mills, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Additional file 8 of Receptor deorphanization in an echinoderm reveals kisspeptin evolution and relationship with SALMFamide neuropeptides

, 2022
Additional file 8. CLuster Analysis of Sequences (CLANS) of A. rubens kisspeptin-type receptors (ArKPR1-11) and other kisspeptin-type receptors from bilaterian taxa.
Scrivens, James H., Queen Mary University of London, dos Reis, Mario, Teesside University, University of Exeter, Zampronio, Cleidiane G., University of Warwick, Slade, Susan E., Escudero Castelán, Nayeli, Semmens, Dean C., Zandawala, Meet, Jones, Alexandra M., Institut Pasteur de Tunis, Mirabeau, Olivier, Guerra, Luis Alfonso Yañez, University of Würzburg, Biosciences Research Group, Elphick, Maurice R.   +17 more
core   +2 more sources

Fluvoxamine Inhibited NLRP3 and NF‐κB Inflammatory Pathways and Maintained Genital Functions by Ameliorating CD‐MPR, KISS‐1, AQP4 and Claudin‐1 Expressions

Basic & Clinical Pharmacology & Toxicology
Fluvoxamine (FLV), a selective serotonin reuptake inhibitor, is commonly used to treat anxiety, major depressive disorder and obsessive‐compulsive disorder, among other psychiatric conditions.
Ş. Topsakal, O. Ozmen, Kadriye Nilay Ozcan, H. Aşçı, O. Imeci, M. A. Sevuk, P. Koşar   +6 more
semanticscholar   +1 more source

Factors Associated With Non‐Vasomotor Menopause Symptoms Experienced by 7285 Women: A UK‐Wide National Survey

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To investigate the factors associated with non‐vasomotor menopause symptoms among women in the UK, focusing on the perceived importance of specific symptoms and their association with demographic and treatment‐related factors. Design A cross‐sectional online survey.
Rhianna Davies, Ashwin Goyal, Zachary Nash, Sarah Hillman, Melanie Davies, Nick Panay, Jane Daniels, Tim Hillard, Bonnie Grant, Paula Briggs, Lynne Robinson, Haitham Hamoda, Channa N. Jayasena   +12 more
wiley   +1 more source

Restoring function to inactivating G protein‐coupled receptor variants in the hypothalamic–pituitary–gonadal axis 1

Journal of neuroendocrinology
G protein‐coupled receptors (GPCRs) are central to the functioning of the hypothalamic–pituitary–gonadal axis (HPG axis) and include the rhodopsin‐like GPCR family members, neurokinin 3 receptor, kappa‐opioid receptor, kisspeptin 1 receptor, gonadotropin‐
Tarryn Radomsky, Ross C. Anderson, Robert P. Millar, C. Newton   +3 more
semanticscholar   +1 more source

YÜKSEK FRUKTOZLU DİYETİN KARACİĞERDE GHRELİN VE KİSSPEPTİN DÜZEYLERİNE ETKİLERİNİN İNCELENMESİ [PDF]

, 2023
Purpose: High fructose corn syrup (HFCS) is used commonly in the food industry and has been associated with various diseases including obesity, diabetes and fatty liver.
Abdullah KARADAĞ, Osman GÜLER, Yusuf ÖZAY, Ahmet TÜRK, Büşra ZENCİRCİ, Özay, Yusuf, Karadag, Abdullah, Güler, Osman, Türk, Ahmet, Zencirci, Büşra   +9 more
core   +2 more sources

Biochemical profiling and symptomatology of androgen deficiency in males with cluster headache: A prospective case–control study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background Cluster headache (CH) has historically been considered a male‐dominated disorder, suggesting a role for androgens in its pathophysiology. We aimed to evaluate hormone profiles and symptoms of androgen deficiency in CH.
Willemijn C. Naber, Roemer B. Brandt, Mariël Leon Morales‐Grooters, Ronald van der Wal, Sjoerd A. A. van den Berg, Jelle J. Goeman, Antoinette Maassen van den Brink, Rolf Fronczek   +7 more
wiley   +1 more source

Microvascular endothelial function is blunted in postmenopausal females with frequent hot flushes

Experimental Physiology, EarlyView.
Abstract Hot flushes of menopause are associated with elevated blood pressure (BP) and diminished macrovascular endothelial function, an initiating factor in the onset of atherosclerosis. Whether microvascular endothelial function is impaired in females with hot flushes, however, remains unknown.
William Stokes, Chowdhury Tasnova Tahsin, Miguel F. Anselmo, Stephany Nathe, Emma J. Lee, Soliana Teshome, Marnie L. Vanden Noven, Anne Blaes, Benjamin W. Langworthy, Manda L. Keller‐Ross   +9 more
wiley   +1 more source

Recent advances in polyendocrine metabolic ovarian syndrome, formerly polycystic ovary syndrome, with emphasis on endocrine and metabolic dysfunction and cardiovascular risk

Journal of Internal Medicine, Volume 300, Issue 5, Page 590-609, November 2026.
Abstract Polyendocrine metabolic ovarian syndrome (PMOS), previously known as polycystic ovary syndrome, affects 10%–13% of women of reproductive age and remains underdiagnosed despite its substantial health burden. The introduction of the new PMOS nomenclature in 2026 reflects a fundamental shift in understanding the condition as a lifelong endocrine ...
Maria Forslund, Johanna Melin, Anju E. Joham, Terhi T. Piltonen, D. Aled Rees, Helena J. Teede   +5 more
wiley   +1 more source

The antidepressant-like effects of kisspeptin-10 are reversed by kisspeptin antagonist peptide 234 in male rats [PDF]

Kisspeptins are reported to be the most potent activators of the hypothalamus-pituitary-gonadal (HPG) axis known to date. Kisspeptin potently elicits gonadotropin-releasing hormone (GnRH) release and luteinizing hormone (LH) secretion, even in the pre ...
Ercan, Z., Kacar, E., Kelestimur, H., Bulmus, O., Ertugrul, N.U., Yardimci, A., Serhatlioglu, I., Kelestimur, Haluk, Serhatlioglu, Ihsan, Bulmus, Ozgur, Ertugrul, Nazife Ulker, Yardimci, Ahmet, Ercan, Zubeyde, Kacar, Emine   +13 more
core   +1 more source