Results 1 to 10 of about 126,252 (290)
ELISA measurement of LDL receptors
Journal of Lipid Research, 1990 An enzyme-linked immunosorbent assay was developed for measurement of low density lipoprotein (LDL) receptors. A monospecific polyclonal antibody to LDL receptor purified from rat liver that reacted with rat, mouse, canine, and human LDL receptor was ...
K May, FB Kraemer, J Chen, AD Cooper
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Arteriosclerosis, Thrombosis, and Vascular Biology, 2009 In this article, the history of the LDL receptor is recounted by its codiscoverers. Their early work on the LDL receptor explained a genetic cause of heart attacks and led to new ways of thinking about cholesterol metabolism. The LDL receptor discovery also introduced three general concepts to cell biology: receptor-mediated endocytosis, receptor ...
Michael S. Brown, Joseph L. Goldstein
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LDL-receptor mutations in Europe [PDF]
Human Mutation, 2004 Familial hypercholesterolemia (FH) is a clinical definition for a remarkable increase of cholesterol serum concentration, presence of xanthomas, and an autosomal dominant trait of either increased serum cholesterol or premature coronary artery disease (CAD). The identification of the low-density lipoprotein (LDL)-receptor (LDLR) as the underlying cause
Hartmut H.-J. Schmidt +2 more
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S-nitrosylation of ARH is required for LDL uptake by the LDL receptor [PDF]
Journal of Lipid Research, 2013 The LDL receptor (LDLR) relies upon endocytic adaptor proteins for internalization of lipoproteins. The results of this study show that the LDLR adaptor autosomal recessive hypercholesterolemia protein (ARH) requires nitric oxide to support LDL uptake.
Rita Garuti +5 more
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LDL Receptors in Keratinocytes
Journal of Investigative Dermatology, 1992 The presence of sufficient amounts of cholesterol in the epidermis is necessary for proper functioning of plasma membranes in the viable epidermal cell layers and also for the barrier quality of lipid intercellular bilayers of the stratum corneum. Cholesterol can be generated by local epidermal synthesis, or imported from the circulation as low-density
Maria Ponec +5 more
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A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function [PDF]
Human Molecular Genetics, 2013 A common synonymous single nucleotide polymorphism in exon 12 of the low-density lipoprotein receptor (LDLR) gene, rs688, has been associated with increased plasma total and LDL cholesterol in several populations. Using immortalized lymphoblastoid cell lines from a healthy study population, we confirmed an earlier report that the minor allele of rs688 ...
Gao, Feng +3 more
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Coaxing the LDL Receptor Family into the Fold [PDF]
Cell, 2003 Low-density-lipoprotein (LDL) receptor family members control diverse developmental and physiological pathways. In this issue of Cell, both Culi and Mann and Hsieh et al. report on Boca/MESD, a highly conserved chaperone required for transport of LDLR family proteins to the cell surface.
Joachim Herz, Peter Marschang
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Large impact of low concentration oxidized LDL on angiogenic potential of human endothelial cells: a microarray study. [PDF]
PLoS ONE, 2012 Oxidized LDL (ox-LDL) is a key factor in atherogenesis. It is taken up by endothelial cells primarily by ox-LDL receptor-1 (LOX-1). To elucidate transcriptional responses, we performed microarray analysis on human coronary artery endothelial cells ...
Magomed Khaidakov +8 more
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Lipoprotein lipase-facilitated uptake of LDL is mediated by the LDL receptor [PDF]
Journal of Lipid Research, 2007 LPL mediates the uptake of lipoproteins into different cell types independent of its catalytic activity. The mechanism of this process and its physiological relevance are not clear. Taking into account the importance of the endothelial barrier for lipoprotein uptake, in vitro studies with primary aortic endothelial cells from wild-type and low density ...
Martin Merkel +6 more
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Oxidized low-density lipoproteins and their contribution to atherosclerosis [PDF]
Exploration of CardiologyThe oxidation of lipoproteins has a key role in the development of atherosclerosis, a condition where plaque builds up in artery walls. Research shows that when low-density lipoprotein (LDL) oxidizes, it speeds up atherosclerosis.
Abdullatif Taha Babakr
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