Results 181 to 190 of about 71,229 (198)

Bambi/Akt/Tlr4 axis protects against atherosclerosis by maintaining lipid metabolism homeostasis in macrophages. [PDF]

Lipids Health Dis
Chen X, Tan S, Li S, Su P, Guan H, Xiang A, Zhang L, Wang H, Yu Q.   +8 more
europepmc   +1 more source

Impact of CYP2C19 Genotype Variants on PCSK9 Inhibitor Efficacy in Lipid‐Lowering Among Patients With Symptomatic Intracranial Atherosclerotic Stenosis

Lipids, EarlyView.
ABSTRACT Ischemic stroke is frequently associated with symptomatic intracranial atherosclerotic stenosis (sICAS), is a leading cause of global disability and mortality. Current guidelines recommend dual antiplatelet and intensive statin therapies. Proprotein convertase subtilisin 9/kexin type 9 (PCSK9) inhibitors have emerged as a potent lipid‐lowering
Chao Zhao, Nuan Wang, Di Shi, Hao Zhou, Dan Chen, Guofang Chen   +5 more
wiley   +1 more source

Thermoneutrality Does Not Affect Angiotensin II-Induced Aortic Aneurysms in Hypercholesterolemic Mice. [PDF]

J Am Heart Assoc
Zhu L, Li B, Franklin MK, Howatt DA, Katsumata Y, Daugherty A, Lu HS.   +6 more
europepmc   +1 more source

Changes in Plasma Sphingolipid Metabolites Following Roux‐En‐Y Gastric Bypass in Women With Obesity and Type 2 Diabetes: A Pilot Metabolomic Cohort Study

Lipids, EarlyView.
ABSTRACT Although sphingolipids are key players in lipotoxicity and metabolic diseases, their response to bariatric surgery and their relation to metabolic improvement remain unclear. This pilot study investigated plasma sphingolipid remodeling after Roux‐en‐Y gastric bypass (RYGB) and its associations with clinical and biochemical markers of ...
Gabriela de Oliveira Lemos, Raquel Susana Torrinhas, Natasha Mendonça Machado, Dan Linetzky Waitzberg   +3 more
wiley   +1 more source

2025 Egyptian guidelines for the management of dyslipidemia. [PDF]

Egypt Heart J
Reda A, Taha HS, Badran HM, Khamis H, Kamal S, Elserafy AS, Dawoud MH, Elamragy AA, Bendary A, Shaker MM.   +9 more
europepmc   +1 more source

Peripheral versus Marrow Lipidomics in Patients with Severe Aplastic Anemia: Potential Indicators for Early Immunosuppressive Treatment Response

Lipids, EarlyView.
ABSTRACT This study aimed to explore the differences of peripheral blood (PB) and bone marrow serum lipidomic profiles in severe aplastic anemia (SAA) patients and their significance in predicting earlier immunosuppressive therapy (IST) response. A cohort of 11 newly diagnosed SAA patients and 15 healthy controls were enrolled between June 2020 and ...
Zexing Sun, Yilei Hong, Yaonan Hong, Chuanao Xin, Qi Liu, Huijin Hu, Yingying Shen, Ying Chen, Shan Liu, Yiping Shen, Yuhong Zhou, Dijiong Wu   +11 more
wiley   +1 more source

Effect of Statins and PCSK9 Inhibition on Metabolic Dysfunction-Associated Steatotic Liver Disease. [PDF]

J Dig Dis
Theocharidou E, Gossios T.
europepmc   +1 more source

Towards Comprehensive Chronic Disease Control: Prevention, Early Detection, and Integrated Management

Medicine Bulletin, EarlyView.
ABSTRACT Chronic non‐communicable diseases (NCDs), including cardiovascular disease, diabetes, cancer, and chronic respiratory conditions, represent the leading causes of morbidity and mortality worldwide. This review examines comprehensive strategies across the continuum of care (from primary prevention and early screening to timely diagnosis ...
Ping Sun, Zhengwei Wan, Yuping Liu
wiley   +1 more source

Cardiovascular Therapeutics at the Crossroads: Pharmacological, Genetic, and Digital Frontiers. [PDF]

Pharmaceuticals (Basel)
Vetrano E, Caturano A, Nilo D, Di Lorenzo G, Tagliaferri G, Piacevole A, Donnarumma M, Iadicicco I, Picco S, Moretto SM, Rocco M, Galiero R, Russo V, Marfella R, Rinaldi L, Bonfrate L, Sasso FC.   +16 more
europepmc   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source