Results 41 to 50 of about 1,700 (74)
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[36] Purification of the LDL receptor
1985Publisher Summary This chapter describes the methods for the purification of the low-density lipoprotein (LDL) receptor from various sources. These methods are designed to enable researchers to obtain chemical amounts of purified receptor from a rich source—the adrenal cortex—and smaller amounts of radiolabeled LDL receptors from less abundant ...
Wolfgang J. Schneider +2 more
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Biochemistry, 1994
This paper provides further characterization of a receptor that, in cells lacking the LDL receptor (FH fibroblasts), mediates lipoprotein binding, uptake, and degradation when incubated with oleate at concentrations not exceeding albumin binding capacity.
Nabil F. Hannouche +8 more
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This paper provides further characterization of a receptor that, in cells lacking the LDL receptor (FH fibroblasts), mediates lipoprotein binding, uptake, and degradation when incubated with oleate at concentrations not exceeding albumin binding capacity.
Nabil F. Hannouche +8 more
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The VLDL receptor: wayward brother of the LDL receptor
Current Opinion in Lipidology, 1995The VLDL receptor binds lipoproteins that contain apolipoprotein E and consists of five functional domains that resemble the LDL receptor. Although the LDL- and VLDL-receptor genes are located on different chromosomes, their gene structure and organization are almost the same.
Hisato Jingami, Tokuo Yamamoto
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Solution Structure of the Sixth LDL-A Module of the LDL Receptor,
Biochemistry, 2000The low-density lipoprotein receptor (LDLR) is the primary mechanism for uptake of plasma cholesterol into cells and serves as a prototype for an entire class of cell surface receptors. The amino-terminal domain of the receptor consists of seven LDL-A modules; the third through the seventh modules all contribute to the binding of low-density ...
Stephen C. Blacklow +1 more
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LDL receptor polymorphisms revisited
Blood, 2010In this issue of Blood , Martinelli and colleagues describe that certain single-nucleotide polymorphisms in the LDL receptor gene independently associate with high plasma levels of coagulation factor VIII in patients with coronary artery disease.[1][1] In 1985, Drs M. S. Brown and J.
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Expression of LDL receptor and uptake of LDL in mouse preimplantation embryos
Molecular and Cellular Endocrinology, 2003The aim of this study is to address the role of low-density lipoprotein (LDL) on mouse preimplantation embryos.The temporal expression of low-density lipoprotein receptor (LDLR) and side-chain cleavage cytochrome P450 (P450scc) mRNAs in mouse oocytes and preimplantation embryos up to the hatched blastocyst stage were analyzed by RT-PCR and nested PCR ...
Yoko Honda +7 more
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1998
Recently we described the specific inhibitory action of lactoferrin on chylomicron remnant (CR) uptake into the intact rat liver. Injection of lactoferrin but not transferrin (7 mg/100 g animal weight) together with radiolabelled CR inhibits in vivo uptake into liver by 50%. No inhibition of uptake into spleen was observed1.
Hans Lassmann +3 more
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Recently we described the specific inhibitory action of lactoferrin on chylomicron remnant (CR) uptake into the intact rat liver. Injection of lactoferrin but not transferrin (7 mg/100 g animal weight) together with radiolabelled CR inhibits in vivo uptake into liver by 50%. No inhibition of uptake into spleen was observed1.
Hans Lassmann +3 more
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Finally, the LDL receptor joins in [PDF]
Blood, 2005 Comment on Bovenschen et al, page [906][1] The LDL receptor is a member of a family of gene products with partially overlapping function. In this issue of Blood , Bovenschen and colleagues describe how members of the LDL receptor gene family cooperate in the regulation of factor VIII.
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Bypassing the LDL Receptor in Familial Hypercholesterolemia
New England Journal of Medicine, 2020Several drug options are available for patients with an elevated plasma cholesterol level who are at increased risk for a cardiovascular event.
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Governance of the concentration of plasma LDL: a reevaluation of the LDL receptor paradigm
Atherosclerosis, 2000The level of LDL in plasma is the major determinantof the risk of vascular disease and lowering the level ofLDL diminishes that risk, both in those with and thosewithout symptomatic vascular disease [1–4]. Fully un-derstanding the factors that govern the concentration ofplasma LDL is, therefore, one of our most importantchallenges.
Allan D. Sniderman +2 more
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