Results 151 to 160 of about 46,677 (173)
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Journal of Chemical Neuroanatomy, 2014
Leptin is mainly produced in the white adipose tissue before being secreted into the blood and transported across the blood-brain barrier. Leptin binds to a specific receptor (LepR) that has numerous subtypes (LepRa, LepRb, LepRc, LepRd, LepRe, and LepRf).
Satoshi Hirako +5 more
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Leptin is mainly produced in the white adipose tissue before being secreted into the blood and transported across the blood-brain barrier. Leptin binds to a specific receptor (LepR) that has numerous subtypes (LepRa, LepRb, LepRc, LepRd, LepRe, and LepRf).
Satoshi Hirako +5 more
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Best Practice & Research Clinical Endocrinology & Metabolism, 2015
The adipokine leptin realizes signal transduction via four different leptin receptor (OB-R) isoforms. The amount of functionally active OB-R, however, is affected by constitutive shedding of the extracellular domain. The product of the cleavage process, the so-called soluble leptin receptor (sOB-R), is the main binding protein for leptin in human blood
Michael Schaab, Juergen Kratzsch
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The adipokine leptin realizes signal transduction via four different leptin receptor (OB-R) isoforms. The amount of functionally active OB-R, however, is affected by constitutive shedding of the extracellular domain. The product of the cleavage process, the so-called soluble leptin receptor (sOB-R), is the main binding protein for leptin in human blood
Michael Schaab, Juergen Kratzsch
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Leukemia & Lymphoma, 2000
The receptor for leptin, the gene product of the obese gene, is expressed in hematopoietic stem cells. Leptin stimulates normal myeloid and erythroid development, and is secreted from bone marrow adipocytes, which occupy most of the marrow cavity in humans.
Takayuki Takubo +5 more
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The receptor for leptin, the gene product of the obese gene, is expressed in hematopoietic stem cells. Leptin stimulates normal myeloid and erythroid development, and is secreted from bone marrow adipocytes, which occupy most of the marrow cavity in humans.
Takayuki Takubo +5 more
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2011
The hormone leptin, secreted predominantly from adipose tissue, plays a crucial role in the regulation of numerous neuroendocrine functions, from energy homeostasis to reproduction. Genetic deficiency as a consequence of leptin or leptin receptor mutations, although rare in humans, leads to early onset of chronic hyperphagia and massive obesity.
Elizabeth C, Cottrell, Julian G, Mercer
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The hormone leptin, secreted predominantly from adipose tissue, plays a crucial role in the regulation of numerous neuroendocrine functions, from energy homeostasis to reproduction. Genetic deficiency as a consequence of leptin or leptin receptor mutations, although rare in humans, leads to early onset of chronic hyperphagia and massive obesity.
Elizabeth C, Cottrell, Julian G, Mercer
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Atomistic mechanism of leptin and leptin-receptor association
Journal of Biomolecular Structure and Dynamics, 2022The leptin-leptin receptor complex is at the very core of energy homeostasis and immune system regulation, among many other functions. In this work, we built homology models of leptin and the leptin binding domain (LBD) of the receptor from humans and mice.
Marisol López-Hidalgo +6 more
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Leptin, Leptin Receptors, and the Control of Body Weight [PDF]
Nutrition Reviews, 2009 The assimilation, storage, and disposition of nutrient energy constitute a complex homeostatic system central to the survival of both prokaryotic and eukaryotic organisms. In vertebrates, and especially among land dwelling mammalian species, the ability to store large quantities of energy-dense fuel in the form of adipose tissue triglyceride permits ...
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Expression of Placental Leptin and Leptin Receptors in Preeclampsia
International Journal of Gynecological Pathology, 2004This study investigated the expression profile of placental leptin and leptin receptor isoforms in preeclampsia, using placental tissue from normal pregnancies that were matched in gestational age and birth weight as controls. A total of 29 cases of preeclampsia were studied by immunohistochemistry, including 16 severe and 13 mild preeclampsia cases ...
Li, RHW, Poon, SCS, Yu, MY, Wong, YF
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Leptin, leptin soluble receptor and coronary atherosclerosis
Experimental and Clinical Endocrinology & Diabetes, 2007AbstractBackground The adipose tissue‐related hormone leptin plays an important role in the regulation of body weight. The associations of leptin and leptin soluble receptor (sOb‐R) with coronary artery disease (CAD) are not clear.Design We measured leptin and sOb‐R in 543 consecutive patients (379 men, 164 women) referred for coronary angiography ...
Stefan Aczel +9 more
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Leptin and leptin receptor-related monogenic obesity
Biochimie, 2012The studies based on candidate genes and encoded proteins known to cause severe obesity in rodents, have shown that these genes also contribute to human early-onset obesity especially for those involved in the leptin pathway: the leptin (LEP) and leptin receptor (LEPR) genes.
Karine Clément, Béatrice Dubern
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Role of leptin and leptin receptors in hematological malignancies
Leukemia & Lymphoma, 2015Leptin is an adipose-derived cytokine that has an important role in bodyweight homeostasis and energy balance. There are a number of studies which have suggested that leptin and its receptors dysregulation play a critical role in the development of malignancies including hematological malignancies, mainly via activation of the JAK/STAT pathway which ...
Ramzi M. Mohammad, Shahab Uddin
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