Results 151 to 160 of about 90,104 (295)

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

Akkermansia muciniphila‐derived hypoacylated rough‐type lipopolysaccharides alleviate diet‐induced obesity via activation of TLR4−IL‐23−IL‐22 immune axis

iMeta, EarlyView.
This study demonstrates that hypoacylated, rough‐type lipopolysaccharides (LPS) derived from Akkermansia muciniphila strain HW07 (ALPS) alleviates diet‐induced obesity. ALPS acts as a weak TLR4 agonist and significantly reduces weight gain, improves metabolic parameters, and restores gut barrier integrity in obese mice.
Li Sun, Yuting Zhang, Wang Dong, Jingzu Sun, Tao Wang, Fei Shao, Huanqin Dai, Junjie Han, Wenzhao Wang, Shuo Wang, Tong Zhao, Liangliang Wang, Chang Liu, Shuangjiang Liu, Hongwei Liu   +14 more
wiley   +1 more source

Determination of Biotin Interference in Pediatric Obesity Related ELISA Research Kits Biotin Interference in Manual ELISA Kits

Journal of Clinical Laboratory Analysis, EarlyView.
In this study, we aimed for the first time to demonstrate biotin interference in ELISA research kits used in the analysis of pediatric obesity parameters other than routine testing. Our study revealed that biotin interaction may occur in manual ELISA kits and may cause erroneous test results.
Ezgi Kürkçü Kahraman, Orkide Donma, Mustafa Metin Donma, Ahsen Yılmaz, Savaş Güzel   +4 more
wiley   +1 more source

Effects of a two‐night hospitalization program as a specific health guidance on obesity and cardiovascular disease risk factors

Journal of General and Family Medicine, EarlyView.
Abstract Background To assess the effects of a two‐night hospitalization program conducted at our hospital as part of a domestic health guidance system. This program is designed for lifestyle modification within a health checkup framework for metabolic syndrome. Methods This is a single‐center, retrospective observational study. We reviewed the medical
Maki Okazaki, Takeshi Katsuki, Hideaki Kurata, Shinichi Tanaka, Hajime Tanaka, Toshihide Kawai   +5 more
wiley   +1 more source

The Leptin Receptor [PDF]

Journal of Biological Chemistry, 1997
openaire   +3 more sources

Bariatric Surgery Lowers Incidence of Chronic Rhinosinusitis and Functional Endoscopic Sinus Surgery

The Laryngoscope, EarlyView.
Obesity is associated with an increased risk of chronic rhinosinusitis (CRS) and increased recurrence of CRS after functional endoscopic sinus surgery (FESS). This study found that in patients with obesity, undergoing bariatric surgery decreases the risk of new‐encounter diagnoses of CRS and results in fewer FESS.
Shvetali Thatte, Mohamad R. Chaaban
wiley   +1 more source

Effects of a high‐fat diet on gut microbiota and possible implications for bone health in male Wistar rats

Lipids, EarlyView.
Abstract Diet plays an important role in the composition of gut microbiota. Emerging research suggests that bone homeostasis can also be influenced by the gut microbiota. The aim of this study was to assess possible alterations in gut microbiota in an experimental obesity model induced by a high‐fat diet (HFD) and the possible effects on parameters of ...
Fernanda Guedes Rodrigues, Milene Subtil Ormanji, Renata Meca, Horácio Montenegro, Lilian Cuppari, Martin H. de Borst, Ita Pfeferman Heilberg   +6 more
wiley   +1 more source

Endothelial cell leptin receptors, leptin and interleukin-8 in the pathogenesis of preeclampsia: An in-vitro study. [PDF]

Turk J Obstet Gynecol, 2017
Arlıer S.
europepmc   +1 more source

Bovine Milk Extracellular Vesicles as a Preventive Treatment for Bone Dysfunction and Metabolic Alterations in Obese Mice Fed a High‐Refined Carbohydrate Diet

Molecular Nutrition &Food Research, EarlyView.
Obesity induction through a high‐refined carbohydrate (HC) diet in BALB/c mice led to increased bone resorption and bone loss in the femur and maxilla. This diet also resulted in increased adiposity, glucose and lipid levels, and insulin resistance. Treatment with bovine milk extracellular vesicles (MEVs) in HC diet‐fed mice demonstrated reduced bone ...
Francine R. F. Silva, Joyce E. Heredia, Onno J. Arntz, Breno R. Barrioni, Mauro M. Teixeira, Tarcília A. Silva, Fons A. J. van de Loo, Soraia Macari, Adaliene V. M. Ferreira, Marina C. Oliveira   +9 more
wiley   +1 more source

Altered Abundance of Butyrate‐Producing Lachnospiraceae by Maternal Diet During Pregnancy Potentially Influences MASLD‐Related Lipid Dysregulation in Male Rat Offspring

Molecular Nutrition &Food Research, EarlyView.
Exposure to undernutrition or overnutrition during the critical period of pregnancy increases susceptibility to metabolic dysfunction‐associated steatotic liver disease (MASLD)–related lipid dysregulation in male rat offspring. The maternal diet during pregnancy altered the relative abundance of specific genera within the Lachnospiraceae family and ...
Soo‐Min Kim, Sunwha Park, AbuZar Ansari, Gain Lee, Young Min Hur, Jeongshin An, Sang Suk Lee, Young‐Ah You, Young Ju Kim   +8 more
wiley   +1 more source