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Localization of Leptin Binding Domain in the Leptin Receptor
Molecular Pharmacology, 1998The leptin receptor is a member of the class I cytokine receptor family and is involved in the control of appetite and body weight. The predicted amino acid sequence of the extracellular region of the cloned leptin receptor differs from that of many other cytokine receptors in that it contains two homologous segments representing potential ligand ...
R.-R. C. Huang +8 more
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Localization of leptin and leptin receptor in the bovine adenohypophysis
Domestic Animal Endocrinology, 2008The present study was carried out to detail the cellular localization of leptin (Lep) and the leptin receptor (LepR) in the bovine adenohypophysis. Lep immunoreactivity (Lep-ir) was found in about 30% of adenohypophysial cells in the gland. Immunochemistry of Lep and specific hormones using serial sections revealed that Lep-ir was present in 60.4% of ...
Kouichi Watanabe +8 more
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Immunoassays for Leptin and Leptin Receptors
2006Availability of methods for accurate and reproducible quantification of lepth in various biological fluids in humans and in animals has greatly facilitated research leading to the understanding of its role in various physiological and pathophysiological conditions. Immunoassay techniques provide a simple and robust tool for measurement of biomolecules.
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Expression of leptin and leptin receptors in gestational trophoblastic diseases
Gynecologic Oncology, 2004To investigate the expression profile of leptin and leptin receptors in gestational trophoblastic diseases (GTDs).Using immunohistochemical staining on archival paraffin-embedded tissue sections, we studied the expression of leptin and leptin receptor in hydatidiform moles, with gestational age-matched normal first-trimester placenta used as control. A
Li, RHW, Yu, MMY, Wong, YF, Cheung, ANY
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Human mast cells express leptin and leptin receptors
Histochemistry and Cell Biology, 2009Mast cells are immune cells that produce and secrete a variety of mediators and cytokines that influence various inflammatory and immune processes. Leptin is a cytokine regulating metabolic, endocrine as well as immune functions via the leptin receptor which is expressed by many immune cells.
Taildeman, Jasmien +10 more
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Research in Veterinary Science, 2013
Leptin is a Ob gene product secreted mainly by adipose tissue. Several reports showed leptin production by other tissue including the ovary. The action of leptin is mediated upon binding to its receptor widely expressed in reproductive tissues in different species.
ALBRIZIO, MARIA +5 more
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Leptin is a Ob gene product secreted mainly by adipose tissue. Several reports showed leptin production by other tissue including the ovary. The action of leptin is mediated upon binding to its receptor widely expressed in reproductive tissues in different species.
ALBRIZIO, MARIA +5 more
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The involvement of leptin in humans revealed by mutations in leptin and leptin receptor genes
Trends in Pharmacological Sciences, 1999Support for our work comes mostly from the Centre National de la Recherche Scientifique, the Institut National de la Sante et de la Recherche Medicale, the University of Paris VII, the Ministry for Research and Technology. We are also grateful for help from the Ligue Nationale contre le Cancer, the Fondation pour la Recherche Medicale Francaise and ...
Arthur Donny Strosberg, Tarik Issad
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Homology Modeling of Human Leptin/ Leptin Receptor Complex
Biochemical and Biophysical Research Communications, 2000Leptin receptor mediates the weight regulatory signal carried by the adipocyte-secreted peptide hormone, leptin. It is important to understand the atomic interactions between leptin and the receptor for the therapeutic applications. However, the structure of leptin receptor has not yet been determined. Leptin shows structural similarity to G-CSF, while
Hisato Jingami +3 more
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Serum leptin levels, skin leptin and leptin receptor expression in psoriasis
British Journal of Dermatology, 2008Recent studies support the relation of psoriasis with obesity and cardiovascular disease. Leptin, a peptide hormone secreted predominantly from adipose tissue, is involved in the regulation of energy intake and expenditure. Recently, it has been shown to have several immunological effects including induction of proinflammatory cytokine production.To ...
Mehmet Onur Elbasi +5 more
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