Results 191 to 200 of about 2,543,592 (233)
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Role of bile acids and bile acid receptors in metabolic regulation.
Physiological Reviews, 2009The incidence of the metabolic syndrome has taken epidemic proportions in the past decades, contributing to an increased risk of cardiovascular disease and diabetes.
P. Lefebvre +4 more
semanticscholar +1 more source
The Lipoprotein Receptor Concept
Drugs, 1988The interaction of plasma lipoproteins with mammalian cells is facilitated by specific receptors on the cell surface. The chylomicron remnant receptor recognises apolipoprotein E (apo E) and mediates the uptake of chylomicron remnants by the liver. The low density lipoprotein (LDL) receptor recognises lipoproteins containing apolipoprotein B100 or an ...
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Lipoprotein receptors in perspective
Current Opinion in Lipidology, 1992Recent findings regarding mutant founder genes, structure/function relationships and regulation of the LDL receptor are reviewed. New aspects regarding the control of the LDL receptor-related protein are presented. The structure and function of the scavenger receptor and the physiological role of the HDL receptor are considered.
Deneys R. van der Westhuyzen +1 more
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Cellular signalling by lipoprotein receptors
Current Opinion in Lipidology, 2000Lipoprotein receptors are commonly thought merely to mediate the internalization of lipoprotein particles or the exchange of lipids at the cell surface. Recent findings have now implicated these multifunctional receptors in cellular signalling mechanisms that extend beyond simple ligand endocytosis.
Michael Gotthardt +2 more
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Lipoprotein receptors and atherosclerosis
Biochemical Society Transactions, 1989The whole lipoprotein spectrum of human plasma may be divided into atherosclerotic and anti-atherosclerotic lipoproteins. To the first class belong apolipoprotein (apo) B and some apoE-containing lipoproteins of the very-low-density (VLDL), intermediate-density (IDL) and low-density (LDL) lipoprotein fractions.
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Lipoprotein and receptor interactions in vivo
Current Opinion in Lipidology, 1995A substantial number of animal models aimed at the genetic dissection of lipid metabolism have been generated recently. Transgenic and knockout mice, in which the receptors or apolipoproteins are overexpressed or destroyed, combined with virus-mediated gene transfer in vivo have advanced our understanding of the complex physiological and ...
Joachim Herz, Thomas E. Willnow
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Lipoprotein receptors: therapeutic implications
Journal of Hypertension, 1990Knowledge of the transport pathways for cholesterol in blood helps us to understand the mechanisms underlying genetic and acquired forms of hypercholesterolaemia, and sets the stage for rational treatment with diet and drugs. A key element is a cell-surface receptor that binds cholesterol-rich lipoproteins of intermediate and low density.
Joseph L. Goldstein, Michael S. Brown
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Functional role of lipoprotein receptors in Alzheimer's disease.
Current Alzheimer Research, 2008The LDL receptor gene family constitutes a class of structurally closely related cell surface receptors fulfilling diverse functions in different organs, tissues, and cell types.
S. Jaeger, C. Pietrzik
semanticscholar +1 more source
Lipoprotein receptors in the vascular wall
Current Opinion in Lipidology, 2004We will discuss the diverse roles of lipoprotein receptors that contribute to the maintenance and integrity of the vascular wall.Lipoprotein receptors function not only as transporters for cholesterol and other lipids. They also act as sensors and signal transducers through which the endothelium, macrophages and smooth muscle cells communicate with ...
Joachim Herz, David Y. Hui
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2002
Aspects of lipoprotein receptor-mediated metabolism of the major cholesterol- and triacylglycerol-carrying lipoproteins are described. The main apolipoproteins of these particles, apoB and apoE, are important recognition partners of relevant receptors. The introduction deals with general aspects of human lipoprotein metabolic pathways.
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Aspects of lipoprotein receptor-mediated metabolism of the major cholesterol- and triacylglycerol-carrying lipoproteins are described. The main apolipoproteins of these particles, apoB and apoE, are important recognition partners of relevant receptors. The introduction deals with general aspects of human lipoprotein metabolic pathways.
openaire +3 more sources