Results 111 to 120 of about 24,569 (232)

Diabetes Disrupts the Response of Retinal Endothelial Cells to the Angiomodulator Lysophosphatidic Acid [PDF]

, 2012
The objectives of this study were to investigate how diabetes mellitus (DM) influences responsiveness of retinal neovessels to lysophosphatidic acid (LPA) and to elucidate the underlying mechanism.
Aranda, Jorge, Im, Eunok, Kazlauskas, Andrius, Motiejunaite, Ruta   +3 more
core   +1 more source

Inactivation of the Phosphatase Activity of Soluble Epoxide Hydrolase Modulates SIRT3 and Attenuates Experimental Pulmonary Hypertension

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
Genetic inactivation of the phosphatase activity of soluble epoxide hydrolase prevents the development of pulmonary hypertension in rats, partly through upregulation of SIRT3 expression and decreased cell proliferation and apoptosis‐related proteins. Targeting sEH‐P emerges as a promising therapeutic strategy for pulmonary hypertension.
Matthieu Leuillier, Mustapha Chelgham, Hind Messaoudi, Ly Tu, Severine Ménoret, Raphaël Thuillet, Déborah Groussard, Felix F. Lillich, Mina Ottaviani, Lionel Nicol, Paul Mulder, Marc Humbert, Vincent Richard, Ignacio Anegon, Christophe Morisseau, Ewgenij Proschak, Christophe Guignabert, Jérémy Bellien   +17 more
wiley   +1 more source

Gintonin absorption in intestinal model systems

Journal of Ginseng Research, 2018
Background: Recently, we identified a novel ginseng-derived lysophosphatidic acid receptor ligand, called gintonin. We showed that gintonin induces [Ca2+]i transient-mediated morphological changes, proliferation, and migration in cells expressing ...
Byung-Hwan Lee, Sun-Hye Choi, Hyeon-Joong Kim, Sang-Deuk Park, Hyewhon Rhim, Hyoung-Chun Kim, Sung-Hee Hwang, Seung-Yeol Nah   +7 more
doaj   +1 more source

Metabolic reprogramming of efferocytosis in the tumour microenvironment: From apoptotic‐cell clearance to therapeutic targeting

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
This review systematically deconstructs the pathological efferocytic—metabolic axis in tumours, framing it as a three‐stage, self‐reinforcing cycle: from metabolite‐driven macrophage recruitment, through hijacked surface recognition, to post‐phagocytic metabolic reprogramming that locks in immunosuppression.
Qianlu Yang, Jie Yan, Qianxi Yang
wiley   +1 more source

Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors

Nature Communications, 2018
Acute bronchoconstriction is the leading cause of asthmatic sudden death following allergen exposure. The authors show that the systemic increase of LPA following inhaled allergen or bradykinin challenge activates the carotid bodies through TRPV1 and LPA-
Nicholas G. Jendzjowsky, Arijit Roy, Nicole O. Barioni, Margaret M. Kelly, Francis H. Y. Green, Christopher N. Wyatt, Richard L. Pye, Luana Tenorio-Lopes, Richard J. A. Wilson   +8 more
doaj   +1 more source

Aberrant lipid metabolism: an emerging diagnostic and therapeutic target in ovarian cancer [PDF]

, 2013
Ovarian cancer remains the most lethal gynaecological cancer. A better understanding of the molecular pathogenesis of ovarian cancer is of critical importance to develop early detection tests and identify new therapeutic targets that would increase ...
Agarwal, Anliker, Aoki, Baker, Bensaad, Cai, Carmela Ricciardelli, Carmen Pyragius, Chae, Chajes, Chang, Choi, Daly, Dong, Eck, Eder, Fishman, Gansler, Gatt, Hanada, Hu, Hu, Illuzzi, Imamura, Iwasawa, Jeong, Jiang, Kimura, Kushi, La Vecchia, Lee, Lee, Li, Little, Makhlouf, Maria Fuller, Martin Oehler, Menendez, Migita, Mukherjee, Murthi, Nakamura, Nam, Nam, Nieman, Noguchi, Pan, Pewzner-Jung, Pizer, Ptaszynska, Pustilnik, Radin, Rahman, Ren, Risch, Risch, Ryland, Sawada, Selzner, Shida, Shintani, Siegel, Song, Spiegel, Sutphen, Swanton, Swinnen, Swinnen, Tania, Tokumura, Tomek, Ueda, Umezu-Goto, Van Vlerken, Vidot, Von Haefen, Wang, Watanabe, Xiao, Xu, Xu, Yanagida, Yang, Yu, Zhang, Zhou, Zhou   +86 more
core   +3 more sources

Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen, Binghua Li, Shengjia Wang, Yongzhong Yao, Zhao Huang, Decai Yu   +5 more
wiley   +1 more source

Interaction of Gα₁₂ with Gα₁₃ and Gα_q signaling pathways [PDF]

, 2002
The G(12) subfamily of heterotrimeric G-proteins consists of two members, G(12) and G(13). Gene-targeting studies have revealed a role for G(13) in blood vessel development. Mice lacking the a subunit of G(13) die around embryonic day 10 as the result of
Gu, Jennifer L., Mancino, Valeria, Müller, Stefan, Offermanns, Stefan, Simon, Melvin I.   +4 more
core  

Canoe full of hot paddlers: TRPV1 neurons steering cardiorespiratory control

The Journal of Physiology, EarlyView.
Richard J. A. Wilson, Nicholas Jendzjowsky   +1 more
wiley   +1 more source

Insights Into circRNA‐Mediated Lipid Metabolism in Cancer Progression

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Lipid metabolism reprogramming is one of the most prominent characteristics of cancer, but it is still unclear which regulatory pathways underlie this process in cancer cells. Circular RNAs (circRNAs) represent a novel category of non‐coding RNAs with multifaceted regulatory functions. While the biological roles of circRNAs in cancer have been
Zhiwei Miao, Jingjing Cao, Xiaoyu Wang, Chunyu Zhang, Tongguo Shi   +4 more
wiley   +1 more source