Results 111 to 120 of about 24,225 (232)

The effect of clozapine on mRNA expression for genes encoding G protein-coupled receptors and the protein components of clathrin-mediated endocytosis. [PDF]

, 2013
Clathrin-mediated endocytosis (CME) is an intracellular trafficking mechanism for packaging cargo, including G protein-coupled receptors (GPCRs), into clathrin-coated vesicles (CCVs).
Gurling, HM, Hu, Y, Hunt, SP, McQuillin, A, Rizig, M, Sharp, SI, Weymer, JF   +6 more
core   +1 more source

Gintonin absorption in intestinal model systems

Journal of Ginseng Research, 2018
Background: Recently, we identified a novel ginseng-derived lysophosphatidic acid receptor ligand, called gintonin. We showed that gintonin induces [Ca2+]i transient-mediated morphological changes, proliferation, and migration in cells expressing ...
Byung-Hwan Lee, Sun-Hye Choi, Hyeon-Joong Kim, Sang-Deuk Park, Hyewhon Rhim, Hyoung-Chun Kim, Sung-Hee Hwang, Seung-Yeol Nah   +7 more
doaj   +1 more source

Identification of Blood Pressure‐Associated Metabolites by Integrating Metabolomic and Genetic Analysis

MedComm, Volume 7, Issue 4, April 2026.
This study identified 10 potential causality between metabolites and blood pressure and found potential genetic regulators of two metabolites. Multiomics integration revealed that a genetic variant near the omega‐3 metabolism genes (FADS1/FADS2) may influence blood pressure regulation by modulating prostaglandin E3 levels.
Yuanjiao Liu, Chunxiao Cheng, Xiong‐Fei Pan, Wei Shao, Dan Zhou, Yimin Zhu   +5 more
wiley   +1 more source

Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors

Nature Communications, 2018
Acute bronchoconstriction is the leading cause of asthmatic sudden death following allergen exposure. The authors show that the systemic increase of LPA following inhaled allergen or bradykinin challenge activates the carotid bodies through TRPV1 and LPA-
Nicholas G. Jendzjowsky, Arijit Roy, Nicole O. Barioni, Margaret M. Kelly, Francis H. Y. Green, Christopher N. Wyatt, Richard L. Pye, Luana Tenorio-Lopes, Richard J. A. Wilson   +8 more
doaj   +1 more source

Higher LPA2 and LPA6 mRNA Levels in Hepatocellular Carcinoma Are Associated with Poorer Differentiation, Microvascular Invasion and Earlier Recurrence with Higher Serum Autotaxin Levels.

PLoS ONE, 2016
Hepatocellular carcinoma (HCC) commonly develops in patients with liver fibrosis; in these patients, the blood levels of lysophosphatidic acid (LPA) and its generating enzyme autotaxin (ATX) increase with the liver fibrosis stage. We aimed to examine the
Kenichiro Enooku, Baasanjav Uranbileg, Hitoshi Ikeda, Makoto Kurano, Masaya Sato, Hiroki Kudo, Harufumi Maki, Kazuhiko Koike, Kiyoshi Hasegawa, Norihiro Kokudo, Yutaka Yatomi   +10 more
doaj   +1 more source

From the cytosol to the inner membrane: biogenesis of the mitochondrial carrier family

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Mitochondrial carrier proteins are essential for cellular physiology as they are active in a wide range of metabolic pathways including production of cellular energy, amino acid synthesis, redox balance and ion homeostasis. The double membrane of mitochondria provides a tightly gated environment through which carrier proteins facilitate the ...
Catherine S. Palmer, Phoebe J. Leeming, Diana Stojanovski   +2 more
wiley   +1 more source

Receptor and secreted targets of Wnt-1/beta-catenin signalling in mouse mammary epithelial cells. [PDF]

, 2005
BackgroundDeregulation of the Wnt/ beta-catenin signal transduction pathway has been implicated in the pathogenesis of tumours in the mammary gland, colon and other tissues. Mutations in components of this pathway result in beta-catenin stabilization and
Ashworth, Alan, Enver, Tariq, Kenny, Paraic A   +2 more
core   +3 more sources

G-Protein coupled receptor signalling in pluripotent stem cell-derived cardiovascular cells: Implications for disease modelling [PDF]

, 2015
Human pluripotent stem cell derivatives show promise as an in vitro platform to study a range of human cardiovascular diseases. A better understanding of the biology of stem cells and their cardiovascular derivatives will help to understand the strengths
Dolatshad, NF, Foldes, G, Harding, SE, Hellen, N, Jabbour, R   +4 more
core   +1 more source

Lysophosphatidic acid receptor 1 inhibition: a potential treatment target for pulmonary fibrosis [PDF]

European Respiratory Review
Lysophosphatidic acid (LPA)-mediated activation of LPA receptor 1 (LPAR1) contributes to the pathophysiology of fibrotic diseases such as idiopathic pulmonary fibrosis (IPF) and systemic sclerosis (SSc). These diseases are associated with high morbidity and mortality despite current treatment options.
Volkmann, Elizabeth, Denton, Christopher, Kolb, Martin, Wijsenbeek-Lourens, Marlies, Emson, Claire, Hudson, Krischan, Amatucci, Anthony, Distler, Oliver, Allanore, Yannick, Khanna, Dinesh, Allanore, Yannick   +10 more
openaire   +8 more sources

Interaction of Gα₁₂ with Gα₁₃ and Gα_q signaling pathways [PDF]

, 2002
The G(12) subfamily of heterotrimeric G-proteins consists of two members, G(12) and G(13). Gene-targeting studies have revealed a role for G(13) in blood vessel development. Mice lacking the a subunit of G(13) die around embryonic day 10 as the result of
Gu, Jennifer L., Mancino, Valeria, Müller, Stefan, Offermanns, Stefan, Simon, Melvin I.   +4 more
core