Results 1 to 10 of about 6,064 (188)

Lysophospholipid receptors in neurodegeneration and neuroprotection [PDF]

Exploration of Neuroprotective Therapy
The central nervous system (CNS) is one of the most complex physiological systems, and treatment of CNS disorders represents an area of major medical need.
Eric Birgbauer
doaj   +4 more sources

Lysophospholipid receptors in vertebrate development, physiology, and pathology

Journal of Lipid Research, 2009
Lysophospholipid (LP) research has experienced a period of renaissance with the discovery of the lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) receptors in the late 1990s.
Athanasia Skoura, Timothy Hla
doaj   +3 more sources

Autocrine/paracrine lysophosphatidylserine signaling suppresses B cell aggregation and tertiary lymphoid structure formation [PDF]

iScience
Summary: Accumulating evidence suggests that Gα13 signaling by G protein-coupled receptors negatively regulate B cell function. We report here that lysophosphatidylserine (LysoPS), an emerging immunoregulatory lysophospholipid, is produced upon B cell ...
Akiharu Uwamizu, Yuji Shinjo, Jumpei Omi, Manae Tatstumi, Kuniyuki Kano, Kumiko Makide, Hajime Kitamura, Michiyo Okudaira, Keita Satoh, Fumiya Fukami, Tasuku Kawano, Tomomitsu Miyasaka, Tomoko Takahashi, Osamu Nakajima, Tomohiko Ohwada, Asuka Inoue, Junken Aoki   +16 more
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Class II Phosphoinositide 3-Kinases Contribute to Endothelial Cells Morphogenesis [PDF]

, 2013
PMCID: PMC3539993This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Catapano, AL, Chiozzotto, D, Falasca, M, Maffucci, T, Mavrommati, I, Norata, GD, Pineiro, R, Tibolla, G, Wheeler, AP   +8 more
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The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life. [PDF]

PLoS ONE, 2015
Autotaxin (ATX, Enpp2) is a secreted lysophospholipase D catalysing the production of lysophosphatidic acid, a pleiotropic growth factor-like lysophospholipid.
Aggeliki Katsifa, Eleanna Kaffe, Nefeli Nikolaidou-Katsaridou, Aris N Economides, Susan Newbigging, Colin McKerlie, Vassilis Aidinis   +6 more
doaj   +1 more source

Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery [PDF]

, 2010
<b>BACKGROUND AND PURPOSE</b> Anandamide and sphingosine-1-phosphate (S1P) both regulate vascular tone in a variety of vessels. This study aimed to examine the mechanisms involved in the regulation of coronary vascular tone by anandamide and ...
Alemany, Alewijnse, Alexander, Ancellin, Blazquez, Chun, Coussin, Felder, French, Galve-Roperh, Giuliano, Grainger, Hajrasouliha, Hemmings, Hemmings, Herradon, Ho, Ho, Howlett, Igarashi, Igarashi, Ikeda, Jarai, Kobayashi, Long, Melendez, Mukhopadhyay, Mulvany, Nofer, O'Sullivan, Offertaler, Oka, Paugh, Peters, Pitson, Pratt, Pyne, Pyne, Romano, Roviezzo, Sanchez, Sarkar, Smart, Sukocheva, Taha, Venkataraman, White, Zygmunt   +47 more
core   +2 more sources

Sphingosine 1-phosphate receptors: do they have a therapeutic potential in cardiac fibrosis? [PDF]

, 2017
Sphingosine 1-phosphate (S1P) is a bioactive lipid that is characterized by a peculiar mechanism of action. In fact, S1P, which is produced inside the cell, can act as an intracellular mediator, whereas after its export outside the cell, it can act as ...
Frati, Alessia, Meacci, Elisabetta, Monaco, Lucia, Pierucci, Federica, Vestri, Ambra   +4 more
core   +2 more sources

Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse [PDF]

, 2019
In the isolated rat carotid artery, the endocannabinoid anandamide induces endothelium-dependent relaxation via activation of the enzyme sphingosine kinase (SK).
Alganga, Husam, Ballantyne, Margaret D., Ewart, Marie-Ann, Fertig, Bracy, Greig, Fiona H., Kazi, Zeshan H., Kennedy, Simon, Nather, Katrin, Pyne, Nigel J., Pyne, Susan, Zaborska, Karolina E.   +10 more
core   +2 more sources

Lysophosphatidic acid (LPA)-antibody (504B3) engagement detected by interferometry identifies off-target binding

Lipids in Health and Disease, 2021
Background Lysophosphatidic acid (LPA) is a bioactive lysophospholipid that acts through its six cognate G protein-coupled receptors. As a family, lysophospholipids have already produced medicines (e.g., sphingosine 1-phosphate) as is being pursued for ...
Manisha Ray, Yasuyuki Kihara, Darryl J. Bornhop, Jerold Chun   +3 more
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Advances in lysophosphatidic acid for bone remodeling [PDF]

Kouqiang yixue
Lysophosphatidic acid (LPA), a simple bioactive lysophospholipid widely dispersed in human body, has been reported to regulate the proliferation, chemotaxis and differentiation of multiple cells and further participate in various developmental and ...
ZHANG Qin, XIANG Lin, GONG Ping
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