Results 11 to 20 of about 6,064 (188)
The Scientific World Journal, 2001 The First International Conference on “Lysophospholipids and Related Bioactive Lipids in Biology and Diseases” was held in Tucson, AZ on June 10 14, 2001, under the sponsorship of the Federation of American Societies of Experimental Biology (FASEB). More
Edward J. Goetzl +2 more
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Lysophospholipid receptors in drug discovery [PDF]
Experimental Cell Research, 2015 Lysophospholipids (LPs), including lysophosphatidic acid (LPA), sphingosine 1-phospate (S1P), lysophosphatidylinositol (LPI), and lysophosphatidylserine (LysoPS), are bioactive lipids that transduce signals through their specific cell-surface G protein-coupled receptors, LPA1-6, S1P1-5, LPI1, and LysoPS1-3, respectively.
Yasuyuki, Kihara +2 more
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Lysophospholipid G Protein-coupled Receptors [PDF]
Journal of Biological Chemistry, 2004 The many biological responses documented for lysophospholipids that include lysophosphatidic acid and sphingosine 1-phosphate can be mechanistically attributed to signaling through specific G protein-coupled receptors. At least nine receptors have now been identified, and the total number is likely to be larger.
Brigitte, Anliker, Jerold, Chun
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Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein [PDF]
, 2006 Oxidation of low-density lipoprotein (LDL) generates pro-inflammatory and pro-thrombotic mediators that play a crucial role in cardiovascular and inflammatory diseases.
Siess, Wolfgang
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Fingolimod for the Treatment of Relapsing-Remitting Multiple Sclerosis
Türk Nöroloji Dergisi, 2017 Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system and is characterized by inflammation, demyelination, and axonal loss.
Burcu Altunrende +3 more
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Roles of polyunsaturated fatty acids, from mediators to membranes
Journal of Lipid Research, 2020 PUFAs, such as AA and DHA, are recognized as important biomolecules, but understanding their precise roles and modes of action remains challenging. PUFAs are precursors for a plethora of signaling lipids, for which knowledge about synthetic pathways and ...
Takeshi Harayama, Takao Shimizu
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Journal of Pharmacological Sciences, 2022 Lysophosphatidic acid (LPA) is a biologically active lysophospholipid, and acts on six types of LPA receptors (LPA1-LPA6). LPA-LPA1 signaling has been suggested as a therapeutic target for inflammatory and fibrotic disorders, including renal fibrosis.In ...
Takumi Naruse +2 more
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A single amino acid determines preference between phospholipids and reveals length restriction for activation ofthe S1P4 receptor [PDF]
, 2004 Background<br/><br/> Sphingosine-1-phosphate and lysophosphatidic acid (LPA) are ligands for two related families of G protein-coupled receptors, the S1P and LPA receptors, respectively.
Fells, J.I. +6 more
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Lysophospholipid receptor nomenclature review: IUPHAR Review 8 [PDF]
British Journal of Pharmacology, 2014 Lysophospholipids encompass a diverse range of small, membrane‐derived phospholipids that act as extracellular signals. The signalling properties are mediated by 7‐transmembrane GPCRs, constituent members of which have continued to be identified after their initial discovery in the mid‐1990s.
Yasuyuki Kihara +3 more
openaire +2 more sources
Novel lysophosphoplipid receptors: their structure and function
Journal of Lipid Research, 2014 It is now accepted that lysophospholipids (LysoGPs) have a wide variety of functions as lipid mediators that are exerted through G protein-coupled receptors (GPCRs) specific to each lysophospholipid.
Kumiko Makide +6 more
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