Results 71 to 80 of about 6,064 (188)

Rho/ROCK pathway is essential to the expansion, differentiation, and morphological rearrangements of human neural stem/progenitor cells induced by lysophosphatidic acid[S]

Journal of Lipid Research, 2013
We previously reported that lysophosphatidic acid (LPA) inhibits the neuronal differentiation of human embryonic stem cells (hESC). We extended these studies by analyzing LPA舗s effects on the expansion of neural stem/progenitor cells (NS/PC) derived from
Frisca Frisca, Duncan E. Crombie, Mirella Dottori, Yona Goldshmit, Alice Pébay   +4 more
doaj   +1 more source

DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses-Inflammations and Cancers Can Have High Genomic Risks. [PDF]

, 2018
Under inflammatory conditions, inflammatory cells release reactive oxygen species (ROS) and reactive nitrogen species (RNS) which cause DNA damage. If not appropriately repaired, DNA damage leads to gene mutations and genomic instability.
Chen, Hongping, Choi, Eric T., Cueto, Ramon, Drosatos, Konstantinos, Fu, Hangfei, Nanayakkara, Gayani K, Park, Joon Y., Qin, Xuebin, Shao, Lijian, Shao, Ying, Sheng, Haitao, Sun, Jianxin, Sun, Yu, Wang, Hong, Wang, Luqiao, Wu, Na, Yang, Qian, Yang, William Y, Yang, Wuping, Yang, Xiaofeng, Zeng, Huihong, Zhu, Qingxian   +21 more
core   +2 more sources

Lysophospholipid receptor activation of RhoA and lipid signaling pathways [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2013
The lysophospholipids sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) signal through G-protein coupled receptors (GPCRs) which couple to multiple G-proteins and their effectors. These GPCRs are quite efficacious in coupling to the Gα(12/13) family of G-proteins, which stimulate guanine nucleotide exchange factors (GEFs) for RhoA ...
Sunny Yang, Xiang, Stephanie S, Dusaban, Joan Heller, Brown   +2 more
openaire   +2 more sources

Lipidomic Analysis of Plasma Extracellular Vesicles from Adiponectin Deficient Mice or Metabolic Syndrome Patients Reveals Pro‐Oxidative and Pro‐Inflammatory Lipid Signatures Correlating with Metabolic Dysfunction

Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
Adiponectin deficiency remodels the lipid composition of plasma extracellular vesicles (EV), enriching polyunsaturated phospholipids and reducing lysophospholipids. These remodelled EV impact oxidative, inflammatory and metabolic function in recipient cells.
Sungji Cho, Hye Kyoung Sung, Khang Nguyen, Yubin Lei, Sivaporn Wannaiampikul, Brian Lee, Eddie Tam, Yihan Luo, Evgeniy V. Petrotchenko, Christoph H. Borchers, Kacey J. Prentice, Scott A Summers, Dylan Burger, Gary Sweeney   +13 more
wiley   +1 more source

Exploring SK/S1P/S1PR pathway as a target for antiviral drug development

Health Sciences Review
Lysophospholipids are a class of simple phospholipids that shows their biological effects through various G protein-coupled receptors (GPCRs). Sphingosine 1-phosphate (S1P) is one of the most studied lysophospholipid having wide role in various ...
Sharada Prasanna Swain, Chandra Sekhara Mahanta, Madan Maurya, Debabrata Mandal, Vipan Parihar, V. Ravichandiran   +5 more
doaj   +1 more source

Lipid receptor S1P₁ activation scheme concluded from microsecond all-atom molecular dynamics simulations.

PLoS Computational Biology, 2013
Sphingosine 1-phosphate (S1P) is a lysophospholipid mediator which activates G protein-coupled sphingosine 1-phosphate receptors and thus evokes a variety of cell and tissue responses including lymphocyte trafficking, endothelial development, integrity ...
Shuguang Yuan, Rongliang Wu, Dorota Latek, Bartosz Trzaskowski, Slawomir Filipek   +4 more
doaj   +1 more source

Docosatetraenoyl LPA is elevated in exhaled breath condensate in idiopathic pulmonary fibrosis [PDF]

, 2014
Background: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease with no effective medical therapies. Recent research has focused on identifying the biological processes essential to the development and progression of fibrosis, and on ...
Berdyshev, Evgeny V, Brenner, Laura N, Gorshkova, Irina A, Mathai, Susan K, Montesi, Sydney B, Shea, Barry S, Tager, Andrew M   +6 more
core   +2 more sources

Diversity of FAAL enzymes and prediction of their substrate specificity using FAALPred

Protein Science, Volume 35, Issue 2, February 2026.
Abstract FAALs (fatty acyl‐AMP ligases) recruit and incorporate fatty acids during the biosynthesis of secondary metabolites. Their diversity, distribution, and substrate specificity remain poorly understood, which limits functional predictions from sequence data.
Anne Liong, Leandro de Mattos Pereira, Pedro N. Leão   +2 more
wiley   +1 more source

Metabolism of polyunsaturated fatty acids in human bone marrow derived mesenchymal stromal cells [PDF]

, 2017
The application of human bone marrow derived mesenchymal stromal cells (hBMSCs) for regenerative or immunomodulatory therapies, e.g. treatment of the graft-versus-host disease, requires in vitro expansion of the cells.
Tigistu-Sahle, Feven
core  

Ghrelin axis genes, peptides and receptors : recent findings and future challenges [PDF]

, 2011
The ghrelin axis consists of the gene products of the ghrelin gene (GHRL), and their receptors, including the classical ghrelin receptor GHSR. While it is well-known that the ghrelin gene encodes the 28 amino acid ghrelin peptide hormone, it is now also ...
Seim, Inge, Josh, Peter, Cunningham, Peter, Herington, Adrian, Chopin, Lisa K.   +4 more
core   +2 more sources