Results 1 to 10 of about 81,527 (268)

Metabotropic glutamate receptors in cancer [PDF]

Neuropharmacology, 2017
Metabotropic glutamate receptors (mGluRs) are widely known for their roles in synaptic signaling. However, accumulating evidence suggests roles of mGluRs in human malignancies in addition to synaptic transmission. Somatic cell homeostasis presents intriguing possibilities of mGluRs and glutamate signaling as novel targets for human cancers.
Lumeng J. Yu, Brian Wall, J. Wangari-Talbot, Suzie Chen   +3 more
semanticscholar   +4 more sources

The Role of Glutamate Receptors in Epilepsy

Biomedicines, 2023
Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing an indispensable role in neuronal development and memory formation. The dysregulation of glutamate receptors and the glutamatergic system is involved in numerous
Tsang-Shan Chen, Tzu-Hsin Huang, Ming-Chi Lai, Chin-Wei Huang   +3 more
doaj   +2 more sources

Kinetic fingerprinting of metabotropic glutamate receptors

Communications Biology, 2023
FRET and confocal patch-clamp fluorometry in oocytes is used to analyze glutamateinduced conformational changes and dimerization of mGluR 1-8 homo- and heterodimers.
Taulant Kukaj, Christian Sattler, Thomas Zimmer, Ralf Schmauder, Klaus Benndorf   +4 more
doaj   +3 more sources

Role of Metabotropic Glutamate Receptors in Neurological Disorders

Frontiers in Molecular Neuroscience, 2019
Glutamate is a fundamental excitatory neurotransmitter in the mammalian central nervous system (CNS), playing key roles in memory, neuronal development, and synaptic plasticity.
Rosalia Crupi, Daniela Impellizzeri, Salvatore Cuzzocrea, Salvatore Cuzzocrea   +3 more
doaj   +2 more sources

Optical Control of Metabotropic Glutamate Receptors [PDF]

Nature Neuroscience, 2013
G protein-coupled receptors (GPCRs), the largest family of membrane signaling proteins, respond to neurotransmitters, hormones and small environmental molecules. The neuronal function of many GPCRs has been difficult to resolve because of an inability to gate them with subtype specificity, spatial precision, speed and reversibility. To address this, we
Joshua Levitz, C. Pantoja, Benjamin M. Gaub, Harald Janovjak, Andreas Reiner, Adam Hoagland, David Schoppik, Brian E Kane, Philipp S. Stawski, A. Schier, D. Trauner, E. Isacoff   +11 more
semanticscholar   +5 more sources

Metabotropic Glutamate Receptors Inhibit Microglial Glutamate Release

ASN Neuro, 2012
Pro-inflammatory stimuli evoke an export of glutamate from microglia that is sufficient to contribute to excitotoxicity in neighbouring neurons. Since microglia also express various glutamate receptors themselves, we were interested in the potential ...
Stephen M McMullan, Bounleut Phanavanh, Gary Guo Li, Steven W Barger   +3 more
doaj   +2 more sources

Conformational diversity in class C GPCR positive allosteric modulation [PDF]

Nature Communications
The metabotropic glutamate receptors (mGlus) are class C G protein-coupled receptors (GPCR) that form obligate dimers activated by the major excitatory neurotransmitter L-glutamate.
Giuseppe Cannone, Ludovic Berto, Fanny Malhaire, Gavin Ferguson, Aurelien Fouillen, Stéphanie Balor, Joan Font-Ingles, Amadeu Llebaria, Cyril Goudet, Abhay Kotecha, Vinothkumar K.R., Guillaume Lebon   +11 more
doaj   +2 more sources

Metabotropic Glutamate Receptors for Parkinson's Disease Therapy

Parkinson's Disease, 2013
Excessive glutamatergic signalling within the basal ganglia is implicated in the progression of Parkinson’s disease (PD) and inthe emergence of dyskinesia associated with long-term treatment with L-DOPA.
Fabrizio Gasparini, Thérèse Di Paolo, Baltazar Gomez-Mancilla   +2 more
doaj   +2 more sources

Chronic Glutamate Toxicity in Neurodegenerative Diseases—What is the Evidence?

Frontiers in Neuroscience, 2015
Together with aspartate, glutamate is the major excitatory neurotransmitter in the brain. Glutamate binds and activates both ligand-gated ion channels (ionotropic glutamate receptors) and a class of G-protein coupled receptors (metabotropic glutamate ...
Jan Lewerenz, Pamela Maher
exaly   +3 more sources

Targeting metabotropic glutamate receptors for novel treatments of schizophrenia

Molecular Brain, 2017
Support for the N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis of schizophrenia has led to increasing focus on restoring proper glutamatergic signaling as an approach for treatment of this devastating disease.
James Maksymetz, Sean P. Moran, P. Jeffrey Conn   +2 more
doaj   +2 more sources