Results 111 to 120 of about 112,349 (256)

Metabotropic glutamate receptors: Phosphorylation and receptor signaling

Journal of Neuroscience Research, 2007
AbstractMetabotropic glutamate receptors (mGluRs) play important roles in neurotransmission, neuronal development, synaptic plasticity, and neurological disorders. Recent studies have revealed a sophisticated interplay between mGluRs and protein kinases: activation of mGluRs regulates the activity of a number of kinases, and direct phosphorylation of ...
Chul Hoon, Kim, Jinu, Lee, Jae-Youn, Lee, Katherine W, Roche   +3 more
openaire   +3 more sources

Modulation of the GABAergic pathway for the treatment of fragile X syndrome. [PDF]

, 2014
Fragile X syndrome (FXS) is the most common genetic cause of intellectual disability and the most common single-gene cause of autism. It is caused by mutations on the fragile X mental retardation gene (FMR1) and lack of fragile X mental retardation ...
Hagerman, Randi J, Hare, Emma B, Lozano, Reymundo   +2 more
core   +1 more source

Effect of novel metabotropic glutamate receptor 5 antagonist on gastroesophageal reflux in dogs during anaesthesia

Journal of Small Animal Practice, EarlyView.
Objectives Gastroesophageal reflux during anaesthesia is a common event occurring in dogs with the potential to cause oesophageal injury and aspiration pneumonia. The objective of the current study was to evaluate the effect of the novel metabotropic glutamate receptor 5 antagonist TT001 on gastroesophageal reflux during anaesthesia in dogs using two ...
A. Glovéus, C. Ekstrand, A. Flöhr, S. Viskjer, O. Höglund   +4 more
wiley   +1 more source

Mechanisms associated with activation of intracellular metabotropic glutamate receptor, mGluR5 [PDF]

, 2016
The group 1 metabotropic glutamate receptor, mGluR5, is found on the cell surface as well as on intracellular membranes where it can mediate both overlapping and unique signaling effects.
Jong, Yuh-Jiin I, O\u27Malley, Karen L
core   +2 more sources

How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle

Psychiatry and Clinical Neurosciences, EarlyView.
Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang, Kubra Trabzonlu, Emily Fullard Jones, Yasir Ahmed Syed   +3 more
wiley   +1 more source

Glycine Potentiates AMPA Receptor Function through Metabotropic Activation of GluN2A-containing NMDA Receptors

Frontiers in Molecular Neuroscience, 2016
NMDA receptors are Ca2+-permeable ion channels. The activation of NMDA receptors requires agonist glutamate and co-agonist glycine. Recent evidence indicates that NMDA receptor also has metabotropic function.
Li-Jun Li, Rong Hu, Rong Hu, Brendan Lujan, Juan Chen, Jian-Jian Zhang, Yasuko Nakano, Tian-Yuan Cui, Ming-Xia Liao, Jin-Cao Chen, Hengye Man, Hua Feng, Qi Wan, Qi Wan, Qi Wan, Qi Wan   +15 more
doaj   +1 more source

Contribution of Cystine-Glutamate Antiporters to the Psychotomimetic Effects of Phencyclidine [PDF]

, 2008
Altered glutamate signaling contributes to a myriad of neural disorders, including schizophrenia. While synaptic levels are intensely studied, nonvesicular release mechanisms, including cystine–glutamate exchange, maintain high steady-state glutamate ...
A Baskys, A Breier, A Meister, A Meister, AJ Cochilla, AK Malhotra, Aric Madayag, AW MacDonald III, AY Shih, B Moghaddam, B Moghaddam, D Jabaudon, DA Baker, DA Baker, David A Baker, DC Javitt, DD Schoepp, DD Schoepp, DE Featherstone, DM Barch, DP Purohit, DR Weinberger, DS Gupta, DS Lorrain, E Pileblad, ED Luby, F Faltus, F Sams-Dodd, G Hu, G Hu, G Kohr, G Paxinos, GD Pearlson, GJ Marek, H Augustin, H Homayoun, H Sato, H Sies, HB Uylings, HF Bradford, Ilangovan Raju, J Cartmell, J Kilbride, JA Lieberman, James H Meador-Woodruff, JB Manent, JH Cabungcal, JH Krystal, JH Krystal, JM Williamson, JY Kim, K Aoyama, KQ Do, L Lu, Lars V Kristiansen, LE Chavez-Noriega, M D'Ascenzo, M Herrera-Marschitz, M Verhage, ME Jackson, MM Moran, O Valenti, P Steullet, PD Harvey, R Corbett, R Takahata, S Bannai, S Chaki, SA Petersen, SJ Sigrist, SM Deneke, Vahram Haroutunian, W Hauber, W Timmerman, WA Abbott, WE Bunney, Y Huang, ZX Xi, ZX Xi   +78 more
core   +2 more sources

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings [PDF]

, 2016
Herein, we have reviewed the role of glutamate, the major excitatory neurotransmitter in the brain, in a number of neurochemical, -physiological, and -behavioral processes mediating the development of alcohol dependence.
Aal-Aaboda, Abe, Abulseoud, Ady, Agrawal, Alasmari, Alhaddad, Arriza, Babu, Bard, Bauer, Beattie, Begleiter, Bell, Bell, Bell, Bell, Bell, Bell, Besheer, Besheer, Besheer, Bischoff, Bockaert, Bondy, Bäckström, Béïque, Cannady, Cannella, Carlezon, Chandler, Chandler, Chefer, Chen, Chen, Cicero, Cloninger, Cohen-Gilbert, Comasco, Cotton, Cowen, Cozzoli, Cozzoli, Cozzoli, Crabbe, Danbolt, Das, Ding, Ding, Domart, Edenberg, Edenberg, Ehlers, El-Husseini, Ende, Enoch, Falco, Flatscher-Bader, Floyd, Fotuhi, Funke, Garbett, Garner, Gass, Gass, Goodwani, Gould, Goulding, Grace, Griffin, Hargreaves, Harris, Henley, Hermann, Hermens, Hodge, Isaac, Jaffrey, Jani, Jin, Joslyn, Kalivas, Kapasova, Kapoor, Karkkainen, Karpyak, Kimpel, Klugmann, Kohda, Konno, Koob, Kornau, Kranzler, Kryger, Krystal, Kuo, Kupila, Lallemand, Lappalainen, Laukkainen, Lester, Levey, Lin, Lin, Loh, Lominac, Long, Lum, Lüscher, Maday, Malenka, Malinow, Mardones, Matsumoto, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McClintick, McCool, Meinhardt, Melendez, Mokdad, Monaghan, Morris, Nevo, Niciu, Obara, Olive, Orth, O’Connor, O’Connor, Patten, Petrakis, Petralia, Preuss, Qrunfleh, Quintero, Rani, Rao, Rao, Reed, Rehm, Rehm, Reich, Reimers, Reissner, Richter, Rietschel, Risher, Rodd, Rodd, Romano, Rothstein, Sala, Sari, Sari, Sari, Sari, Sari, Schnell, Schroeder, Schroeder, Schuckit, Schumann, Selim, Shaw, Sheng, Shigemoto, Shiraishi-Yamaguchi, Spanagel, Staples, Steketee, Swartzwelder, Swartzwelder, Swerdlow, Szumlinski, Szumlinski, Szumlinski, Szumlinski, Tamaru, Tanaka, Tao-Cheng, Tarazi, Terranova, Thoma, Tomita, Traynelis, Van Bockstaele, Vengeliene, Wadiche, Wang, Warburton, Ward, Watterson, Williams, Witzmann, Wong, Worley, Xia, Xiao, Yan, Zamora-Martinez, Zhao, Zhou, Zhou, Ziff   +212 more
core   +1 more source

Astrocytes: Orchestrators of brain gas exchange and oxygen homeostasis

The Journal of Physiology, EarlyView.
Abstract figure legend Oxygen and carbon dioxide enter the body via breathing; in the brain astrocytes play a key role balancing oxygen delivery with carbon dioxide removal. Abstract If we consider neurons like muscles during exercise, the demand for oxygen (O2) and carbon dioxide (CO2) elimination is constantly changing.
Isabel N. Christie
wiley   +1 more source