Results 111 to 120 of about 81,074 (260)

Selective Actions of Novel Allosteric Modulators Reveal Functional Heteromers of Metabotropic Glutamate Receptors in the CNS

Journal of Neuroscience, 2014
Metabotropic glutamate (mGlu) receptors play important roles in regulating CNS function and are known to function as obligatory dimers. Although recent studies have suggested heterodimeric assembly of mGlu receptors in vitro, the demonstration that ...
Shen Yin, M. Noetzel, Kari A. Johnson, Rocio Zamorano, N. Jalan‐Sakrikar, K. Gregory, P. Conn, C. Niswender   +7 more
semanticscholar   +1 more source

Oxygen/Glucose deprivation induces a reduction in synaptic AMPA receptors on hippocampal CA3 neurons mediated by mGluR1 and adenosine A3 receptors [PDF]

, 2011
Hippocampal CA1 pyramidal neurons are highly sensitive to ischemic damage, whereas neighboring CA3 pyramidal neurons are less susceptible. It is proposed that switching of AMPA receptor (AMPAR) subunits on CA1 neurons during an in vitro model of ischemia,
Cimarosti, Helena, Dennis, Siobhan, Hanley, Jonathan G., Henley, Jeremy M., Jaafari, Nadia, Mellor, Jack R.   +5 more
core   +1 more source

Activation requirements for metabotropic glutamate receptors [PDF]

Neuroscience Letters, 2013
It has been common experimentally to use high frequency, tetanic, stimulation to activate metabotropic glutamate receptors (mGluRs) in cortex and thalamus. To determine what type of stimulation is actually necessary to activate mGluRs we examined the effects of varying stimulation duration and intensity on activating mGluR responses.
S. Murray Sherman, Angela N. Viaene, Iraklis Petrof   +2 more
openaire   +3 more sources

Genetic and Pharmacological Inhibition of Metabotropic Glutamate Receptor Signalling Extends Lifespan in Drosophila

Aging Cell, EarlyView.
We show that genetic and pharmacological inhibition of the metabotropic glutamate receptor, DmGluRA extends Drosophila lifespan, improves stress tolerance and alters early‐life locomotion. Several markers indicative of reduced ribosomal biogenesis, a hallmark of longevity, were also detected in these flies.
Cui Guan, Abigail Otchere, Mihails Laskovs, Irene Papatheodorou, Cathy Slack   +4 more
wiley   +1 more source

Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodies. [PDF]

, 2014
BackgroundIn dementia with Lewy bodies (DLB) abnormal interactions between α-synuclein (α-syn) and beta amyloid (Aβ) result in selective degeneration of neurons in the neocortex, limbic system and striatum.
Cartier, Anna, Desplats, Paula, Masliah, Eliezer, Overk, Cassia R, Patrick, Christina, Price, Diana L, Rockenstein, Edward, Shaked, Gideon, Spencer, Brian, Ubhi, Kiren   +9 more
core   +3 more sources

Transcriptional Heterogeneity and Differential Response of Rod Photoreceptor Pathway Uncovered by Single‐Cell RNA Sequencing of the Aging Mouse Retina

Aging Cell, EarlyView.
Healthy aging is accompanied by transcriptional dysregulation in retinal cells, leading to alterations in key molecular pathways and cellular responses, with the scotopic pathway being particularly affected. We show that rod photoreceptors, essential for initiating scotopic (low‐light) vision, exhibit selective vulnerability to aging‐associated ...
Laura Campello, Matthew J. Brooks, Benjamin R. Fadl, Hyo Sub Choi, Soumitra Pal, Anand Swaroop   +5 more
wiley   +1 more source

Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 delta glutamate receptors

EMBO Reports, 2014
The orphan GluD2 receptor belongs to the ionotropic glutamate receptor family but does not bind glutamate. Ligand‐gated GluD2 currents have never been evidenced, and whether GluD2 operates as an ion channel has been a long‐standing question.
Visou Ady, J. Perroy, L. Tricoire, C. Piochon, S. Dadak, Xiaoru Chen, I. Dusart, L. Fagni, B. Lambolez, C. Levenes   +9 more
semanticscholar   +1 more source

Targeting glutamate metabolism in melanoma [PDF]

arXiv, 2019
The glutamate metabotropic receptor 1 (GRM1) drives oncogenesis when aberrantly activated in melanoma and several other cancers. Metabolomics reveals that patient-derived xenografts with GRM1-positive melanoma tumors exhibit elevated plasma glutamate levels associated with metastatic melanoma in vivo. Stable isotope tracing and GCMS analysis determined
arxiv  

The prion protein regulates glutamate-mediated Ca2+ entry and mitochondrial Ca2+ accumulation in neurons [PDF]

, 2017
The cellular prion protein (PrPC) whose conformational misfolding leads to the production of deadly prions, has a still-unclarified cellular function despite decades of intensive research.
Bertoli, Alessandro, Castellani, Angela, Giacomello, Marta, Lim, Dmitry, Mario, Agnese De, Massimino, Maria Lina, Peggion, Caterina, Sorgato, Maria Catia, Viviani, Francesca   +8 more
core   +1 more source

Short-Term Postsynaptic Plasticity Facilitates Predictive Tracking in Continuous Attractors [PDF]

arXiv, 2023
The N-methyl-D-aspartate receptor (NMDAR) is a crucial component of synaptic transmission, and its dysfunction is implicated in many neurological diseases and psychiatric conditions. NMDAR-based short-term postsynaptic plasticity (STPP) is a newly discovered postsynaptic response facilitation mechanism.
arxiv