Results 221 to 230 of about 81,074 (260)

Modulation of Excitation by Metabotropic Glutamate Receptors

2007
Metabotropic glutamate receptors, in contrast to ionotropic glutamate receptors, do not form ion channels but instead affect intracellular chemical messenger systems. They couple via GTP-binding proteins ("G-proteins") to a variety of effectors such as ion channels and thus give glutamate, the major excitatory transmitter in the CNS, the ability to ...
Marylka Uusisaari, Thomas Knöpfel
openaire   +3 more sources

Get receptive to metabotropic glutamate receptors

Current Opinion in Neurobiology, 1995
Glutamate activates not only ionotropic glutamate receptors, but also G-protein-coupled receptors, called metabotropic glutamate receptors. Recent studies have revealed that these metabotropic receptors share distinctive structural properties and that they form a subgroup within the heptahelical receptor family.
Jean-Philippe Pin, Joël Bockaert
openaire   +3 more sources

Exciting Times beyond the Brain: Metabotropic Glutamate Receptors in Peripheral and Non-Neural Tissues

Pharmacological Reviews, 2011
Metabotropic glutamate (mGlu) receptors are G-protein-coupled receptors expressed primarily on neurons and glial cells, where they are located in the proximity of the synaptic cleft.
M. Julio-Pieper, Peter J. Flor, T. Dinan, J. Cryan   +3 more
semanticscholar   +1 more source

Coordinate regulation of metabotropic glutamate receptors

Current Opinion in Neurobiology, 2001
Recent studies aimed at identifying the mechanisms that regulate the signaling of metabotropic glutamate receptors (mGluRs) have revealed that both protein kinase and protein phosphatase activity are important in directly modulating mGluR function. The inter-relationship between phosphorylation and dephosphorylation of mGluRs seems to be an important ...
Scott D. Sorensen, Sudarkodi Alagarsamy, P. Jeffrey Conn   +2 more
openaire   +3 more sources

Sequence and expression of a metabotropic glutamate receptor

Nature, 1991
The complementary DNA of a metabotropic glutamate receptor coupled to inositol phosphate/Ca2+ signal transduction has been cloned and characterized. This receptor shows no sequence similarity to conventional G protein-coupled receptors and has a unique structure with large hydrophilic sequences at both sides of seven putative membrane-spanning domains.
Yasuto Tanabe, Masayuki Masu, Kunihiro Tsuchida, Ryuichi Shigemoto, Shigetada Nakanishi   +4 more
openaire   +3 more sources

Perisynaptic Location of Metabotropic Glutamate Receptors mGluR1 and mGluR5 on Dendrites and Dendritic Spines in the Rat Hippocampus

European Journal of Neuroscience, 1996
Ionotropic and metabotropic (mGluR1a) glutamate receptors were reported to be segregated from each other within the postsynaptic membrane at individual synapses.
R. Luján, Z. Nusser, J. Roberts, R. Shigemoto, P. Somogyi   +4 more
semanticscholar   +1 more source

Metabotropic glutamate receptors

Pharmacology Biochemistry and Behavior, 2002
openaire   +3 more sources

Metabotropic glutamate receptors and neurodegenerative diseases.

Pharmacological Research, 2017
F. Ribeiro, L. Vieira, Rita G. W. Pires, R. P. Olmo, S. Ferguson   +4 more
semanticscholar   +1 more source

Metabotropic glutamate receptors in the hypothalamus

Neuroscience Research Communications, 1997
SORTINO M. A., CANONICO, Pier Luigi
openaire   +2 more sources

The metabotropic glutamate receptors

Trends in Pharmacological Sciences, 1995
openaire   +2 more sources