L-Glutamate supplementation improves small intestinal architecture and enhances the expressions of jejunal mucosa amino acid receptors and transporters in weaning piglets. [PDF]
PLoS ONE, 2014 L-Glutamate is a major oxidative fuel for the small intestine. However, few studies have demonstrated the effect of L-glutamate on the intestinal architecture and signaling of amino acids in the small intestine.
Meng Lin +7 more
doaj +1 more source
Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
Nature Communications, 2017 Glutamine metabolism is well known to support tumour growth. Here the authors show that cancer cells also utilize glutamine to promote invasiveness by converting it to glutamate, which upon secretion activates metabotropic glutamate receptors to ...
Emmanuel Dornier +13 more
doaj +1 more source
Biological Research, 2014 BACKGROUND: The hippocampal CA3 area contains large amounts of vesicular zinc in the mossy fiber terminals which is released during synaptic activity, depending on presynaptic calcium.
Carlos M Matias +3 more
doaj +1 more source
Molecular docking studies of N-substituted 4-methoxy-6-oxo-1-aryl-pyridazine-3-carboxamide derivatives as potential modulators of glutamate receptors [PDF]
Research Results in Pharmacology, 2020 Introduction: The virtual target-oriented screening is a necessary stage of modern drug-design. In the present study, the affinity of pyridazine derivatives for the most promising antiparkinsonian biotargets – I–III groups of metabotropic and ionotropic ...
Hanna I. Severina +5 more
doaj +3 more sources
A population of immature cerebellar parallel fibre synapses are insensitive to adenosine but are inhibited by hypoxia [PDF]
, 2011 The purine adenosine plays an important role in a number of physiological and pathological processes and is neuroprotective during hypoxia and ischemia.
Atterbury, Alison, Wall, Mark J.
core +1 more source
Metabotropic Glutamate Receptors
Journal of Biological Chemistry, 2015 Background: C. elegans encodes three metabotropic glutamate receptors: mgl-1, mgl-2, and mgl-3. Results: mgl-1 and mgl-3, but not mgl-2, modulate activity in the neural circuit underlying feeding behavior.
J. Dillon +8 more
semanticscholar +1 more source
Advanced Biology, EarlyView.Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams +7 more
wiley +1 more source
Mechanism of neuroprotective effect of mGluR4 agonists [PDF]
Research Results in Pharmacology, 2019 Introduction: This review of literature is to demonstrate a role of group III metabotropic glutamate receptors in maintaining the level of extracellular glutamate in ischemic stroke and neurodegenerative diseases.
Natalya V. Avdeeva +4 more
doaj +3 more sources
Reduction in Phencyclidine Induced Sensorimotor Gating Deficits in the Rat Following Increased System Xc − Activity in the Medial Prefrontal Cortex [PDF]
, 2013 Rationale: Aspects of schizophrenia, including deficits in sensorimotor gating, have been linked to glutamate dysfunction and/or oxidative stress in the prefrontal cortex. System xc −, a cystine–glutamate antiporter, is a poorly understood mechanism that
A Araque +81 more
core +2 more sources
Neuro‐Cancer Interactions Shape Glioma Intratumoral Heterogeneity
Advanced Science, EarlyView.This review proposes a conceptual framework for understanding glioma intratumoral heterogeneity shaped by neuro‐cancer interactions: functional patterns and transcriptional states. Functional patterns manifest as three major neural‐like adaptations with spatial and potentially hierarchical relationships, including neurogliomal synapses, glioma networks,
Tong Wu +8 more
wiley +1 more source