Results 101 to 110 of about 38,001 (122)

Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain.

Science, 1984
In rats ischemia of the forebrain induced by a 30-minute occlusion of the carotid artery, followed by 120 minutes of arterial reperfusion, produced ischemic lesions of selectively vulnerable pyramidal cells in both hippocampi.
R. Simon, J. H. Swan, T. Griffiths, B. Meldrum   +3 more
semanticscholar   +1 more source

Functional and pharmacological differences between recombinant N-methyl-D-aspartate receptors.

Journal of Neurophysiology, 1998
N-methyl-D-aspartic acid (NMDA) receptors transiently transfected into mammalian HEK-293 cells were characterized with subunit-specific antibodies and electrophysiological recordings. Deactivation time course recorded in response to fast-glutamate pulses
S. Vicini, Jian Feng Wang, Jinhong Li, W. Zhu, Yue‐hua Wang, Jian‐hong Luo, B. Wolfe, D. Grayson   +7 more
semanticscholar   +1 more source

Dopamine D1-dependent trafficking of striatal N-methyl-D-aspartate glutamate receptors requires Fyn protein tyrosine kinase but not DARPP-32.

Molecular Pharmacology, 2004
Interactions between dopaminergic and glutamatergic systems in the striatum are thought to underlie both the symptoms and adverse effects of treatment of Parkinson's disease.
A. Dunah, A. Sirianni, A. Fienberg, E. Bastia, M. Schwarzschild, D. Standaert   +5 more
semanticscholar   +1 more source

N‐Methyl‐D‐Aspartate Receptors and Ethanol: Inhibition of Calcium Flux and Cyclic GMP Production

Journal of Neurochemistry, 1989
: Measurements of calcium uptake and cyclic GMP production by cerebellar granule cells grown in primary culture demonstrated that ethanol preferentially inhibited N‐methyl‐D‐aspartate (NMDA) receptor‐gated cation channel function.
P. Hoffman, C. Rabe, F. Moses, B. Tabakoff   +3 more
semanticscholar   +1 more source

Subunit-Specific Agonist Activity at NR2A-, NR2B-, NR2C-, and NR2D-Containing N-Methyl-d-aspartate Glutamate Receptors

Molecular Pharmacology, 2007
The four N-methyl-d-aspartate (NMDA) receptor NR2 subunits (NR2A-D) have different developmental, anatomical, and functional profiles that allow them to serve different roles in normal and neuropathological situations. Identification of subunit-selective
K. Erreger, M. Geballe, A. Kristensen, Philip E. Chen, K. Hansen, C. Lee, Hongjie Yuan, Phuong Le, P. Lyuboslavsky, N. Micale, Lars Jørgensen, R. Clausen, D. Wyllie, J. Snyder, S. Traynelis   +14 more
semanticscholar   +1 more source

Equilibrium Constants for (R)-[(S)-1-(4-Bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic Acid (NVP-AAM077) Acting at Recombinant NR1/NR2A and NR1/NR2B N-Methyl-d-aspartate Receptors: Implications for Studies of Synaptic Transmission

Molecular Pharmacology, 2006
We have quantified the effects of the N-methyl-d-aspartate (NMDA) receptor antagonist (R)-[(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) at rat recombinant N-methyl-d-aspartate ...
Pamela Frizelle, Philip E. Chen, D. Wyllie   +2 more
semanticscholar   +1 more source

Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids.

Molecular Pharmacology, 1997
Steroid sulfation occurs in nervous tissue and endogenous sulfated steroids can act as positive or negative modulators of N-methyl-D-aspartate (NMDA) receptor function.
M. Park-Chung, Fong-Sen Wu, Robert H. Purdy, A. Malayev, T. T. Gibbs, D. Farb   +5 more
semanticscholar   +1 more source

Astrocytes of the mouse neocortex express functional N‐methyl‐D‐aspartate receptors

The FASEB Journal, 2001
In the brain, N‐methyl‐D‐aspartate (NMDA)‐type glutamate receptors are important elements for the manifestation of memory as well as mediators of neurotoxicity, and they are thought to be exclusive to neurons.
C. Schipke, C. Ohlemeyer, M. Matyash, C. Nolte, Helmut Kettenmann, F. Kirchhoff   +5 more
semanticscholar   +1 more source

Ionotropic glutamate receptors and expression of N-methyl-D-aspartate receptor subunits in subregions of human hippocampus: effects of schizophrenia.

American Journal of Psychiatry, 2000
OBJECTIVE Multiple quantifiable biologic abnormalities have been localized to the hippocampus in schizophrenia. Alterations in glutamate-mediated transmission at N-methyl-D-aspartic acid (NMDA)-sensitive receptors in hippocampus have been implicated in ...
Xue Min Gao, K. Sakai, R. Roberts, R. Conley, B. Dean, C. Tamminga   +5 more
semanticscholar   +1 more source

Activation of microglial N‐methyl‐D‐aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain

Annals of Neurology, 2012
Activated microglia play a central role in the inflammatory and excitotoxic component of various acute and chronic neurological disorders. However, the mechanisms leading to their activation in the latter context are poorly understood, particularly the ...
A. Kaindl, V. Degos, S. Peineau, E. Gouadon, V. Chhor, G. Loron, Tifenn le Charpentier, J. Josserand, C. Ali, D. Vivien, G. Collingridge, A. Lombet, Lina K Issa, F. René, J. Loeffler, A. Kavelaars, C. Verney, J. Mantz, P. Gressens   +18 more
semanticscholar   +1 more source