Results 101 to 110 of about 155,151 (336)
Ruthenium Complexes in Protein Science: Heading a New Generation of Therapeutic and Analytical Tools
Angewandte Chemie, EarlyView.This review presents the latest advances in the development of ruthenium complexes within the field of protein science, highlighting their potential applications in biomedical and bioanalytical fields. Abstract Ruthenium complexes are distinguished by their versatile coordination chemistry, redox behaviors and photochemical properties. In recent years,
Liyan Zhang, Yun Chen, Sylvestre Bonnet
wiley +2 more sources
Anti-N-methyl-D-aspartate receptor encephalitis: one case report
Chinese Journal of Contemporary Neurology and Neurosurgery, 2015 DOI: 10.3969/j.issn.1672-6731.2015.12 ...
Ying CHEN +3 more
doaj
In vivo evidence for NMDA receptor mediated excitotoxicity in a murine genetic model of Huntington Disease [PDF]
, 2008 N-methyl-D-aspartate receptor (NMDAR) mediated excitotoxicity is implicated as a proximate cause of neurodegeneration in Huntington Disease (HD). However, this hypothesis has not been tested rigorously in vivo. NMDAR NR2B-subunits are the predominant NR2
Joe Tsien +4 more
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Advanced Science, EarlyView.Our study reveals a novel mechanism by which palmitoylation regulates ferroptosis and enzalutamide resistance in prostate cancer. Under enzalutamide resistance, the FOXA1/CXXC5/TET2 complex induces aberrant upregulation of ZDHHC2, which subsequently suppresses ferroptosis by mediating S‐palmitoylation of USP19 and degradation of ACSL4 protein in CRPC ...
Shuai Shao +10 more
wiley +1 more source
Direct Inhibition of N-Methyl-D-Aspartate (NMDA)-Receptor Function by Antiglaucomatous β-Antagonists
Journal of Pharmacological Sciences, 2008 In the present study, we investigated the direct effects of antiglaucoma drugs (timolol, betaxolol, pilocarpine, and latanoprost) on N-methyl-D-aspartate (NMDA)-receptor function using a Xenopus oocytes expression system and electrophysiological ...
Tatsuo Nagata +7 more
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Serotonin Modulates Oscillations of the Membrane Potential in Isolated Spinal Neurons from Lampreys [PDF]
, 2002 Studies were performed on spinal neurons from lampreys isolated by an enzymatic/mechanical method using pronase. The effects of 100 µM serotonin (5-HT) on membrane potential oscillations induced by a variety of excitatory amino acids were studied.
Batueva, I. V. +4 more
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Advanced Science, EarlyView.Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang +7 more
wiley +1 more source
Mercury-induced toxicity of rat cortical neurons is mediated through N-methyl-D-Aspartate receptors
Molecular Brain, 2012 Background Mercury is a well-known neurotoxin implicated in a wide range of neurological or psychiatric disorders including autism spectrum disorders, Alzheimer’s disease, Parkinson’s disease, epilepsy, depression, mood disorders and tremor.
Xu Fenglian +6 more
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Advanced Science, EarlyView.Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley +1 more source
D-AMINO ACID OXIDASE: A REVIEW [PDF]
, 2016 Over many years, D-serine and glycine were found to be the endogenous ligands for glycine-binding site for N-methyl-D-aspartate receptors. D-serinebefore being used up by the cells undergoes oxidative deamination by the enzyme D-amino acid oxidase (DAAO)
Nithya S, Ts, Shanmugarajan
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