Results 61 to 70 of about 156,800 (338)

Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling

Advanced Science, EarlyView.
ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li, Chen Wu, Yuqi Zhu, Zicheng Liu, Wenjuan Yu, Andrew Lukwaro, Yu Zhong, Guoqiang Xie, Lili Zhou, Xiaoru Huang, Hui‐yao Lan, Junzhe Chen, Ying Tang   +12 more
wiley   +1 more source

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer’s disease

Neural Regeneration Research
Stroke and Alzheimer’s disease are common neurological disorders and often occur in the same individuals. The comorbidity of the two neurological disorders represents a grave health threat to older populations.
Shan Ping Yu, Emily Choi, Michael Q. Jiang, Ling Wei   +3 more
doaj   +1 more source

D-Amino Acids in the Nervous and Endocrine Systems

Scientifica, 2016
Amino acids are important components for peptides and proteins and act as signal transmitters. Only L-amino acids have been considered necessary in mammals, including humans. However, diverse D-amino acids, such as D-serine, D-aspartate, D-alanine, and D-
Yoshimitsu Kiriyama, Hiromi Nochi
doaj   +1 more source

A via receptor NMDA-óxido nítrico-GMP cíclico como alvo para o desenvolvimento de medicações antipsicóticas não-dopaminérgicas para a esquizofrenia [PDF]

, 2011
Schizophrenia is a devastating disorder that occurs in about 1% of the population worldwide. For over 30 years, it has been considered to be the result of dysfunctional brain dopaminergic pathways.
BAKER, Glen B., DURSUN, Serdar, HALLAK, Jaime E. C., LOBÃO, Bruno, MACHADO-DE-SOUSA, João Paulo, OLIVEIRA, João Paulo Maia de   +5 more
core   +4 more sources

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Anti-N-methyl-D-aspartate receptor encephalitis: three cases report and review of literature

Chinese Journal of Contemporary Neurology and Neurosurgery, 2014
Objective To study the clinical and laboratory features and diagnosis of the patient with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis.
Guan-en ZHOU, Zhong-ping AN
doaj  

Glutamate and post-traumatic cerebral excitoxicity as possible therapeutic targets – A literature review

Brazilian Neurosurgery, 2013
Cerebral edema and excitoxicity are well known phenomena and are reported in multiple pathological contexts. Despite that, regarding traumatic brain injury, significant events in incidence and potential clinical consequences, little is known about the ...
José Luís Alves, Anabela Mota Pinto
doaj   +1 more source

Spermine regulates N-methyl-d-aspartate receptor desensitization

Neuron, 1992
The action of the endogenous polyamine spermine on NMDA-induced responses (in the presence of glycine) was evaluated in cultured spinal cord neurons under voltage- and concentration-clamp conditions. Spermine potentiated NMDA-induced responses in a dose-dependent manner.
openaire   +3 more sources

Microenvironment Self‐Adaptive Nanoarmor to Address Adhesion‐ and Colonization‐Related Obstacles in Impaired Intestine Promote Bacteriotherapy Against Parkinson's Disease

Advanced Science, EarlyView.
A microenvironment self‐adaptive nanoarmor is developed to effectively address the adhesion‐ and colonization‐related challenges posed by multiple physiological and pathological characteristics in the intestine. L. plantarum@MPN@CS showed significant therapeutic potential in treating Parkinson's disease (PD), a model for extraintestinal disorders, as ...
Limeng Zhu, Yuyu Wu, Yingjie Chen, Xiyi Chen, Xingjie Zan, Yanlong Liu, Wujun Geng   +6 more
wiley   +1 more source

Anti-N-methyl-D-aspartate receptor encephalitis: analysis of three cases

Chinese Journal of Contemporary Neurology and Neurosurgery, 2015
Objective To study clinical features, diagnosis, therapy response and prognosis of anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis.  Methods Three cases with anti-NMDAR encephalitis were reported.
Hui SU, Rong-fei WANG, Sheng-yuan YU
doaj