Results 1 to 10 of about 295,560 (194)

Correspondence between gene expression and neurotransmitter receptor and transporter density in the human brain

open access: yesNeuroImage, 2022
Neurotransmitter receptors modulate signaling between neurons. Thus, neurotransmitter receptors and transporters play a key role in shaping brain function.
Justine Y. Hansen   +7 more
doaj   +1 more source

Excitatory and inhibitory receptors utilize distinct post- and trans-synaptic mechanisms in vivo

open access: yeseLife, 2021
Ionotropic neurotransmitter receptors at postsynapses mediate fast synaptic transmission upon binding of the neurotransmitter. Post- and trans-synaptic mechanisms through cytosolic, membrane, and secreted proteins have been proposed to localize ...
Taisuke Miyazaki   +9 more
doaj   +1 more source

Acute reorganization of postsynaptic GABAA receptors reveals the functional impact of molecular nanoarchitecture at inhibitory synapses

open access: yesCell Reports, 2023
Summary: Neurotransmitter receptors partition into nanometer-scale subdomains within the postsynaptic membrane that are precisely aligned with presynaptic neurotransmitter release sites.
Samantha S. Olah   +12 more
doaj   +1 more source

Potential Therapeutic Targeting Neurotransmitter Receptors in Diabetes

open access: yesFrontiers in Endocrinology, 2022
Neurotransmitters are signaling molecules secreted by neurons to coordinate communication and proper function among different sections in the central neural system (CNS) by binding with different receptors.
Xiaohui Pan   +5 more
doaj   +1 more source

Systematic Analysis of Neurotransmitter Receptors in Human Breast Cancer Reveals a Strong Association With Outcome and Uncovers HTR6 as a Survival-Associated Gene Potentially Regulating the Immune Microenvironment

open access: yesFrontiers in Immunology, 2022
Many epidemiological reports have indicated an increase in the incidence of breast cancer among psychotic patients, suggesting that the targets of antipsychotics, neurotransmitter receptors, may have a role in tumorigenesis.
Wei Zhang   +16 more
doaj   +1 more source

Immunoreactivity of Muscarinic Acetylcholine M2 and Serotonin 5-HT2B Receptors, Norepinephrine Transporter and Kir Channels in a Model of Epilepsy

open access: yesLife, 2021
Epilepsy is characterized by an imbalance in neurotransmitter activity; an increased excitatory to an inhibitory activity. Acetylcholine (ACh), serotonin, and norepinephrine (NE) may modulate neural activity via several mechanisms, mainly through its ...
Enes Akyuz   +8 more
doaj   +1 more source

AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release

open access: yesFrontiers in Molecular Neuroscience, 2023
Postsynaptic neurotransmitter receptors and their associated scaffolding proteins assemble into discrete, nanometer-scale subsynaptic domains (SSDs) within the postsynaptic membrane at both excitatory and inhibitory synapses.
Harrison J. Ramsay   +9 more
doaj   +1 more source

GRKs as Modulators of Neurotransmitter Receptors

open access: yesCells, 2020
Many receptors for neurotransmitters, such as dopamine, norepinephrine, acetylcholine, and neuropeptides, belong to the superfamily of G protein-coupled receptors (GPCRs). A general model posits that GPCRs undergo two-step homologous desensitization: the
Eugenia V. Gurevich   +1 more
doaj   +1 more source

Neurotransmitter Specific, Cellular-Resolution Functional Brain Mapping Using Receptor Coated Nanoparticles: Assessment of the Possibility. [PDF]

open access: yes, 2015
Receptor coated resonant nanoparticles and quantum dots are proposed to provide a cellular-level resolution image of neural activities inside the brain. The functionalized nanoparticles and quantum dots in this approach will selectively bind to different
Forati, Ebrahim   +5 more
core   +4 more sources

Computational modeling of trans-synaptic nanocolumns, a modulator of synaptic transmission

open access: yesFrontiers in Computational Neuroscience, 2022
Understanding synaptic transmission is of crucial importance in neuroscience. The spatial organization of receptors, vesicle release properties and neurotransmitter molecule diffusion can strongly influence features of synaptic currents. Newly discovered
Xiaoting Li   +7 more
doaj   +1 more source

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