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Neurotransmitter receptors on microglia [PDF]
Stroke and Vascular Neurology, 2016 As the resident immune cells in the central nervous system, microglia have long been hypothesised to promote neuroinflammation and exacerbate neurotoxicity. However, this traditional view has undergone recent revision as evidence has accumulated that microglia exert beneficial and detrimental effects depending on activation status, polarisation ...
Huan Liu, Xiaoming Hu, Rehana K. Leak
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Mechanism for neurotransmitter-receptor matching [PDF]
Proceedings of the National Academy of Sciences, 2020 SignificanceNeurotransmitter switching generally involves replacement of an excitatory transmitter with an inhibitory transmitter or vice versa and has been linked to changes in animal behavior. There are corresponding switches in postsynaptic receptors that enable continued function of the circuit, but the mechanism by which receptor expression is ...
Dena R. Hammond-Weinberger +3 more
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GRKs as Modulators of Neurotransmitter Receptors [PDF]
Cells, 2020 Many receptors for neurotransmitters, such as dopamine, norepinephrine, acetylcholine, and neuropeptides, belong to the superfamily of G protein-coupled receptors (GPCRs). A general model posits that GPCRs undergo two-step homologous desensitization: the active receptor is phosphorylated by kinases of the G protein-coupled receptor kinase (GRK) family,
Eugenia V. Gurevich +1 more
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Environmental enrichment and neurotransmitter receptors [PDF]
Behavioral and Neural Biology, 1982 The extent of high affinity, specific binding of several pharmacological agents to brain membrane fractions derived from rats reared in an environmentally enriched or impoverished environment has been assayed. The binding of all labeled agents studied was not significantly altered in cerebellar, subcortical, or cortical membranes by the rearing ...
Por, SB, Bennett, EL, Bondy, SC
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Cesium activates the neurotransmitter receptor for glycine [PDF]
Frontiers in Molecular Neuroscience, 2023 The monovalent cations sodium and potassium are crucial for the proper functioning of excitable cells, but, in addition, other monovalent alkali metal ions such as cesium and lithium can also affect neuronal physiology. For instance, there have been recent reports of adverse effects resulting from self-administered high concentrations of cesium in ...
Steffen Fricke +11 more
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Lipids, Neurotransmitters and their Receptors [PDF]
Biophysical Journal, 2017 Neurotransmission by chemical synapses is often described as a simple process, which starts from neurotransmitters release from presynaptic vesicles, is followed by neurotransmitters diffusion through the synaptic cleft to the opposite neuron, and is finally completed by the binding of neurotransmitters to their receptors, thus initializing the ...
Ilpo Vattulainen +4 more
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Nogo-A and the regulation of neurotransmitter receptors
Neural Regeneration Research, 2020 10.4103/1673-5374.282250 ; Neural Regeneration Research ; 15 ; 11 ; 2037 ...
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Synaptic Neurotransmitter-Gated Receptors [PDF]
Cold Spring Harbor Perspectives in Biology, 2012 Since the discovery of the major excitatory and inhibitory neurotransmitters and their receptors in the brain, many have deliberated over their likely structures and how these may relate to function. This was initially satisfied by the determination of the first amino acid sequences of the Cys-loop receptors that recognized acetylcholine, serotonin ...
Pierre Paoletti, Trevor G. Smart
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Endocytosis of Neurotransmitter Receptors: Location Matters [PDF]
Cell, 2007 Endocytosis of excitatory glutamate receptors from the postsynaptic plasma membrane plays a fundamental role in synaptic function and plasticity. In a recent study published in Neuron, Lu et al. (2007) describe protein interactions that link zones of receptor endocytosis directly to the postsynaptic scaffold and propose that local trafficking of ...
Guillermo A. Yudowski +2 more
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The lipid habitats of neurotransmitter receptors in brain
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2016 Neurotransmitter receptors, the macromolecules specialized in decoding the chemical signals encrypted in the chemical signaling mechanism in the nervous system, occur either at the somatic cell surface of chemically excitable cells or at specialized subcellular structures, the synapses.
Borroni, Maria Virginia +2 more
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