Results 1 to 10 of about 296,111 (290)

Correspondence between gene expression and neurotransmitter receptor and transporter density in the human brain

NeuroImage, 2022
Neurotransmitter receptors modulate signaling between neurons. Thus, neurotransmitter receptors and transporters play a key role in shaping brain function.
Justine Y. Hansen, Ross D. Markello, Lauri Tuominen, Martin Nørgaard, Elena Kuzmin, Nicola Palomero-Gallagher, Alain Dagher, Bratislav Misic   +7 more
doaj   +1 more source

Excitatory and inhibitory receptors utilize distinct post- and trans-synaptic mechanisms in vivo

eLife, 2021
Ionotropic neurotransmitter receptors at postsynapses mediate fast synaptic transmission upon binding of the neurotransmitter. Post- and trans-synaptic mechanisms through cytosolic, membrane, and secreted proteins have been proposed to localize ...
Taisuke Miyazaki, Megumi Morimoto-Tomita, Coralie Berthoux, Kotaro Konno, Yoav Noam, Tokiwa Yamasaki, Matthijs Verhage, Pablo E Castillo, Masahiko Watanabe, Susumu Tomita   +9 more
doaj   +1 more source

Acute reorganization of postsynaptic GABAA receptors reveals the functional impact of molecular nanoarchitecture at inhibitory synapses

Cell Reports, 2023
Summary: Neurotransmitter receptors partition into nanometer-scale subdomains within the postsynaptic membrane that are precisely aligned with presynaptic neurotransmitter release sites.
Samantha S. Olah, Dean J. Kareemo, William C. Buchta, Brooke L. Sinnen, Carley N. Miller, Hannah S. Actor-Engel, Sara E. Gookin, Christina S. Winborn, Mason S. Kleinjan, Kevin C. Crosby, Jason Aoto, Katharine R. Smith, Matthew J. Kennedy   +12 more
doaj   +1 more source

Potential Therapeutic Targeting Neurotransmitter Receptors in Diabetes

Frontiers in Endocrinology, 2022
Neurotransmitters are signaling molecules secreted by neurons to coordinate communication and proper function among different sections in the central neural system (CNS) by binding with different receptors.
Xiaohui Pan, Xiaohui Pan, Shibing Tao, Shibing Tao, Nanwei Tong, Nanwei Tong   +5 more
doaj   +1 more source

Systematic Analysis of Neurotransmitter Receptors in Human Breast Cancer Reveals a Strong Association With Outcome and Uncovers HTR6 as a Survival-Associated Gene Potentially Regulating the Immune Microenvironment

Frontiers in Immunology, 2022
Many epidemiological reports have indicated an increase in the incidence of breast cancer among psychotic patients, suggesting that the targets of antipsychotics, neurotransmitter receptors, may have a role in tumorigenesis.
Wei Zhang, Wei Zhang, Wei Zhang, Lintai Li, Lintai Li, Jianxuan Li, Jianxuan Li, Haiyan Yu, Haiyan Yu, Fengping Zheng, Bin Yan, Wanxia Cai, Yumei Chen, Lianghong Yin, Donge Tang, Yong Xu, Yong Dai   +16 more
doaj   +1 more source

Immunoreactivity of Muscarinic Acetylcholine M2 and Serotonin 5-HT2B Receptors, Norepinephrine Transporter and Kir Channels in a Model of Epilepsy

Life, 2021
Epilepsy is characterized by an imbalance in neurotransmitter activity; an increased excitatory to an inhibitory activity. Acetylcholine (ACh), serotonin, and norepinephrine (NE) may modulate neural activity via several mechanisms, mainly through its ...
Enes Akyuz, Zuleyha Doganyigit, Yam Nath Paudel, Betul Koklu, Emin Kaymak, Chiara Villa, Alina Arulsamy, Mohd. Farooq Shaikh, Orrin Devinsky   +8 more
doaj   +1 more source

AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release

Frontiers in Molecular Neuroscience, 2023
Postsynaptic neurotransmitter receptors and their associated scaffolding proteins assemble into discrete, nanometer-scale subsynaptic domains (SSDs) within the postsynaptic membrane at both excitatory and inhibitory synapses.
Harrison J. Ramsay, Sara E. Gookin, Austin M. Ramsey, Dean J. Kareemo, Kevin C. Crosby, Dominik G. Stich, Samantha S. Olah, Hannah S. Actor-Engel, Katharine R. Smith, Matthew J. Kennedy   +9 more
doaj   +1 more source

GRKs as Modulators of Neurotransmitter Receptors

Cells, 2020
Many receptors for neurotransmitters, such as dopamine, norepinephrine, acetylcholine, and neuropeptides, belong to the superfamily of G protein-coupled receptors (GPCRs). A general model posits that GPCRs undergo two-step homologous desensitization: the
Eugenia V. Gurevich, Vsevolod V. Gurevich   +1 more
doaj   +1 more source

Computational modeling of trans-synaptic nanocolumns, a modulator of synaptic transmission

Frontiers in Computational Neuroscience, 2022
Understanding synaptic transmission is of crucial importance in neuroscience. The spatial organization of receptors, vesicle release properties and neurotransmitter molecule diffusion can strongly influence features of synaptic currents. Newly discovered
Xiaoting Li, Xiaoting Li, Xiaoting Li, Gabriel Hémond, Antoine G. Godin, Antoine G. Godin, Nicolas Doyon, Nicolas Doyon   +7 more
doaj   +1 more source

Neurochemical Organization of the Drosophila Brain Visualized by Endogenously Tagged Neurotransmitter Receptors

Cell Reports, 2020
Summary: Neurotransmitters often have multiple receptors that induce distinct responses in receiving cells. Expression and localization of neurotransmitter receptors in individual neurons are therefore critical for understanding the operation of neural ...
Shu Kondo, Takahiro Takahashi, Nobuhiro Yamagata, Yasuhito Imanishi, Hidetaka Katow, Shun Hiramatsu, Katrina Lynn, Ayako Abe, Ajayrama Kumaraswamy, Hiromu Tanimoto   +9 more
doaj   +1 more source