Results 111 to 120 of about 114,328 (209)

Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling

Nature Communications, 2017
ARMMs are extracellular vesicles that bud directly at the plasma membrane; their function is poorly understood. Here the authors purify and carryout a proteomics analysis of the protein components of ARMMs, and show that NOTCH receptors are recruited ...
Qiyu Wang, Quan Lu
doaj   +1 more source

Quantifying cancer epithelial-mesenchymal plasticity and its association with stemness and immune response

, 2019
Cancer cells can acquire a spectrum of stable hybrid epithelial/mesenchymal (E/M) states during epithelial-mesenchymal transition (EMT). Cells in these hybrid E/M phenotypes often combine epithelial and mesenchymal features and tend to migrate ...
Bocci, Federico, Deng, Youyuan, Jia, Dongya, Jolly, Mohit Kumar, Levine, Herbert, Li, Xuefei, Onuchic, Jose N., Tripathi, Shubham   +7 more
core   +1 more source

The Role of Notch Signaling and Gut Microbiota in Autoinflammatory Diseases: Mechanisms and Future Views

Biomedicines
Notch signaling is an evolutionarily conserved, multifunctional pathway involved in cell fate determination and immune modulation and contributes to the pathogenesis of autoinflammatory diseases.
Vincenzo Giambra, Mario Caldarelli, Laura Franza, Pierluigi Rio, Gaja Bruno, Serena di Iasio, Andrea Mastrogiovanni, Antonio Gasbarrini, Giovanni Gambassi, Rossella Cianci   +9 more
doaj   +1 more source

Notch receptors in GtoPdb v.2024.2

IUPHAR/BPS Guide to Pharmacology CITE
The Notch signalling pathway is crucial for cell fate decisions during embryogenesis and in fully developed organisms. Notch receptors (4 genes in humans) are single pass trans-membrane proteins that interact with membrane-bound endogenous peptide ligands from the Delta/Serrate/LAG-2 (DSL) family.
Thiruma V. Arumugam, Christopher Sobey
openaire   +1 more source

Notch signaling in cancer: metabolic reprogramming and therapeutic implications

Frontiers in Immunology
The evolutionarily conserved Notch signaling pathway is essential for cell-fate determination, organogenesis, and tissue homeostasis. Notch receptors and their ligands are transmembrane proteins with epidermal growth factor–like repeats; ligand–receptor ...
Shuang-Shuang Wang, Shuang-Shuang Wang, Shuang-Shuang Wang, Hui-Lin Lv, Hui-Lin Lv, Hui-Lin Lv, Rong-Zu Nie, Rong-Zu Nie, Rong-Zu Nie, Ya-Ping Liu, Ya-Ping Liu, Ya-Ping Liu, Yan-Jie Hou, Yan-Jie Hou, Yan-Jie Hou, Chen Chen, Chen Chen, Chen Chen, Xing-Yue Tao, Xing-Yue Tao, Xing-Yue Tao, Huo-Min Luo, Huo-Min Luo, Huo-Min Luo, Pei-Feng Li, Pei-Feng Li, Pei-Feng Li   +26 more
doaj   +1 more source

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury. [PDF]

, 2019
Traumatic spinal cord injury (SCI) brings numerous inflammatory cells, including macrophages, from the circulating blood to lesions, but pathophysiological impact resulting from spatiotemporal dynamics of macrophages is unknown.
Edgerton, V Reggie, Hara, Masamitsu, Harimaya, Katsumi, Inoue, Kazuhide, Iwamoto, Yukihide, Kijima, Ken, Kobayakawa, Kazu, Kubota, Kensuke, Masuda, Takahiro, Matsumoto, Yoshihiro, Nakashima, Yasuharu, Ohkawa, Yasuyuki, Okada, Seiji, Ozato, Keiko, Saito, Takeyuki, Tamaru, Tetsuya, Tamura, Tomohiko, Tsuda, Makoto, Yokota, Kazuya, Yoshizaki, Shingo   +19 more
core   +1 more source

Notch signaling in cancers: mechanism and potential therapy

Frontiers in Cell and Developmental Biology
The Notch signaling pathway is an evolutionarily conserved intercellular signaling cascade that regulates a number of cellular processes, including cell development, proliferation, apoptosis, and genome stability. The Notch signaling pathway is pervasive
Chen Chen, Yan Du, Rongzu Nie, Shuangshuang Wang, Hang Wang, Peifeng Li   +5 more
doaj   +1 more source

Notch Receptor Intracellular Domain [PDF]

, 2020
openaire   +1 more source

The role of Notch signalling and its crosstalk with oestrogen receptor signalling in breast cancer. [PDF]

Cancer Metastasis Rev
Azadova A, Isayev O, Marco A, Brooke GN.
europepmc   +1 more source

Notch signaling pathway and heart development, congenital heart disease, and myocardial regeneration. [PDF]

Front Bioeng Biotechnol
Liu Y, Wang X, Tao X, Zhang HK, Liu B, Li Y, Wang H, Luo HM, Lv HL, Li P.   +9 more
europepmc   +1 more source