Results 71 to 80 of about 114,328 (209)
Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states [PDF]
, 2014 The Notch signaling pathway consists of multiple types of receptors and ligands, whose interactions can be tuned by Fringe glycosyltransferases. A major challenge is to determine how these components control the specificity and directionality of Notch ...
Elowitz, Michael B. +4 more
core +1 more source
Notch and NF-kB: Coach and Players of Regulatory T-Cell Resposnse in Cancer [PDF]
, 2018 The Notch signaling pathway plays multiple roles in driving T-cell fate decisions, proliferation, and aberrant growth. NF-kB is a cell-context key player interconnected with Notch signaling either in physiological or in pathological conditions.
Bellavia, Diana +5 more
core +2 more sources
The Role of Notch Receptors in Transcriptional Regulation [PDF]
Journal of Cellular Physiology, 2015 Notch signaling has pleiotropic context‐specific functions that have essential roles in many processes, including embryonic development and maintenance and homeostasis of adult tissues. Aberrant Notch signaling (both hyper‐ and hypoactive) is implicated in a number of human developmental disorders and many cancers.
Hongfang, Wang +3 more
openaire +2 more sources
Molecular pathways of Notch signaling in vascular smooth muscle cells
Frontiers in Physiology, 2012 Notch signaling in the cardiovascular system is important during embryonic development, vascular repair of injury, and vascular pathology in humans. The vascular smooth muscle cell (VSMC) expresses multiple Notch receptors throughout its life cycle, and ...
Joshua M. Boucher +3 more
doaj +1 more source
Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival [PDF]
, 2006 There are two types of neural stem cells (NSCs). Primitive NSCs [leukemia inhibitory factor (LIF) dependent but exogenous fibroblast growth factor (FGF) 2 independent] can be derived from mouse embryonic stem (ES) cells in vitro and from embryonic day 5 ...
Chaddah, R +7 more
core +3 more sources
Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand
PLOS ONE, 2016 Delta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand, despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated Notch1 in a luciferase assay, prevented the differentiation of myoblasts through Notch signaling ...
Maxwell Greene +5 more
openaire +4 more sources
Functional conservation of mouse Notch receptor family members [PDF]
FEBS Letters, 1996 All the known members of the mouse Notch receptor family were examined for their biochemical function by interaction with a DNA binding protein RBP‐Jκ. mNotch2, mNotch3 and int3 (= mNotch4) were shown to interact with RBP‐Jκ by the GST‐fusion pull down assay and dominant negative competition with Epstein Barr virus nuclear antigen 2.
Kato, Hisamune +7 more
openaire +2 more sources
Journal of Biological Chemistry, 2022 NOTCH1 is a transmembrane receptor that initiates a signaling pathway involved in embryonic development of adult tissue homeostasis. The extracellular domain of NOTCH1 is composed largely of epidermal growth factor-like repeats (EGFs), many of which can be O-fucosylated at a specific consensus sequence by protein O-fucosyltransferase 1 (POFUT1).
Florian Pennarubia +3 more
openaire +2 more sources
BMC Research Notes, 2021 Objective The Delta-Notch signaling pathway induces fine-grained patterns of differentiation from initially homogeneous progenitor cells in many biological contexts, including Drosophila bristle formation, where mathematical modeling reportedly suggests ...
Masaharu Yoshihara +6 more
doaj +1 more source
Retinal regeneration requires dynamic Notch signaling
Neural Regeneration Research, 2022 Retinal damage in the adult zebrafish induces Müller glia reprogramming to produce neuronal progenitor cells that proliferate and differentiate into retinal neurons. Notch signaling, which is a fundamental mechanism known to drive cell-cell communication,
Leah J Campbell +3 more
doaj +1 more source