Results 61 to 70 of about 55,247 (173)

Implication of Opioid Receptors in the Antihypertensive Effect of a Novel Chicken Foot-Derived Peptide

open access: yesBiomolecules, 2020
The peptide AVFQHNCQE demonstrated to produce nitric oxide-mediated antihypertensive effect. This study investigates the bioavailability and the opioid-like activity of this peptide after its oral administration.
Anna Mas-Capdevila   +5 more
doaj   +1 more source

Effects of kappa-opioid agonist U-50488 and p38 MAPK inhibitor SB203580 on the spike activity of pyramidal neurons in the basolateral amygdala [PDF]

open access: yesResearch Results in Pharmacology 10(1): 1-6 (2024)
Introduction: Kappa-opioid receptor (KOR) signaling in the basolateral amygdala (BLA) underlies KOR agonist-induced aversion. In this study, we aimed to understand the individual and combined effects of KOR agonist U-50488 and p38 MAPK inhibitor SB203580 on the spiking activity of pyramidal neurons in the BLA to shed light on the complex interplay ...
arxiv   +1 more source

Opioid receptors

open access: yesGenome Biology, 2001
Mouse μ-opioid receptor carboxy-terminal splice variants have been shown to differ in their responses to agonists.
openaire   +2 more sources

IUPHAR Review - Bivalent and bifunctional opioid receptor ligands as novel analgesics

open access: yesPharmacological Research, 2023
Though efficacious in managing chronic, severe pain, opioid analgesics are accompanied by significant adverse effects including constipation, tolerance, dependence, and respiratory depression.
Kyle J. Rehrauer   +1 more
doaj  

Synthesis, Biological Evaluation, and SAR Studies of 14β-phenylacetyl Substituted 17-cyclopropylmethyl-7, 8-dihydronoroxymorphinones Derivatives: Ligands With Mixed NOP and Opioid Receptor Profile

open access: yesFrontiers in Psychiatry, 2018
A series of 14β-acyl substituted 17-cyclopropylmethyl-7,8-dihydronoroxymorphinone compounds has been synthesized and evaluated for affinity and efficacy for mu (MOP), kappa (KOP), and delta (DOP) opioid receptors and nociceptin/orphanin FQ peptide (NOP ...
Vinod Kumar   +6 more
doaj   +1 more source

Straub tail, the deprivation effect and addiction to aggression [PDF]

open access: yesarXiv, 2006
It has been observed that male mice who are consistently winning fights with conspecifics can raise their tail, which is very similar to a morphine-induced Straub tail response. Since this response is a typical index of opiate activation, it has been proposed that the opioidergic systems of such mice are chronically activated.
arxiv  

Towards Better Opioid Antagonists Using Deep Reinforcement Learning [PDF]

open access: yesarXiv, 2020
Naloxone, an opioid antagonist, has been widely used to save lives from opioid overdose, a leading cause for death in the opioid epidemic. However, naloxone has short brain retention ability, which limits its therapeutic efficacy. Developing better opioid antagonists is critical in combating the opioid epidemic.Instead of exhaustively searching in a ...
arxiv  

Opiate Drugs with Abuse Liability Hijack the Endogenous Opioid System to Disrupt Neuronal and Glial Maturation in the Central Nervous System

open access: yesFrontiers in Pediatrics, 2018
The endogenous opioid system, comprised of multiple opioid neuropeptide and receptor gene families, is highly expressed by developing neural cells and can significantly influence neuronal and glial maturation. In many central nervous system (CNS) regions,
Kurt F. Hauser   +5 more
doaj   +1 more source

Identifying Risk of Opioid Use Disorder for Patients Taking Opioid Medications with Deep Learning [PDF]

open access: yesarXiv, 2020
The United States is experiencing an opioid epidemic, and there were more than 10 million opioid misusers aged 12 or older each year. Identifying patients at high risk of Opioid Use Disorder (OUD) can help to make early clinical interventions to reduce the risk of OUD.
arxiv  

Opioids and opioid receptors; understanding pharmacological mechanisms as a key to therapeutic advances and mitigation of the misuse crisis

open access: yesBJA Open, 2023
Opioids are a mainstay in acute pain management and produce their effects and side effects (e.g., tolerance, opioid-use disorder and immune suppression) by interaction with opioid receptors.
David G. Lambert
doaj  

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