Results 51 to 60 of about 188,491 (243)

Pattern recognition receptors and inflammasome: Now and beyond

Molecules and Cells
: Pattern recognition receptors (PRRs) are fundamental to the innate immune system, functioning to detect and eliminate invading pathogens by inhibiting their replication and limiting host tissue damage.
SuHyeon Oh, Young Ki Choi, SangJoon Lee
doaj   +1 more source

Pattern Recognition Receptors and Infectious Diseases [PDF]

, 2012
Our bodies are under constant attack from pathogens. Despite this continual bombardment, under normal circumstances we remain healthy for most of our lives. This protection against infectious and harmful agents is provided by our immune system. The immune system can be broken into two elements: adaptive immunity and innate immunity.
Jopeace, Ardi Liaunardy, Howard, Chris B., Murton, Ben L., Edwards, Alexander D., Monie, Tom P.   +4 more
openaire   +3 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Natural Cytotoxicity Receptors: Pattern Recognition and Involvement of Carbohydrates

The Scientific World Journal, 2005
Natural cytotoxicity receptors (NCRs), expressed by natural killer (NK) cells, trigger NK lysis of tumor and virus-infected cells on interaction with cell-surface ligands of these target cells.
Angel Porgador
doaj   +1 more source

PRRDB: A comprehensive database of Pattern-Recognition Receptors and their ligands

BMC Genomics, 2008
Background Recently in a number of studies, it has been demonstrated that the innate immune system doesn't merely acts as the first line of defense but provides critical signals for the development of specific adaptive immune response.
Lata Sneh, Raghava Gajendra
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Pattern recognition receptors: function, regulation and therapeutic potential

Signal Transduction and Targeted Therapy
Pattern recognition receptors (PRRs) are sensors in the immune system, detecting pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs).
Ruochan Chen, Ju Zou, Jiawang Chen, Xiao Zhong, Rui Kang, Daolin Tang   +5 more
doaj   +1 more source

Bacterial and Fungal Pattern Recognition Receptors in Homologous Innate Signaling Pathways of Insects and Mammals

Frontiers in Microbiology, 2015
In response to bacterial and fungal infections in insects and mammals, distinct families of innate immune pattern recognition receptors initiate highly complex intracellular signaling cascades.
Bethany A Stokes, Shruti eYadav, Upasana eShokal, L Courtney Smith, Ioannis eEleftherianos   +4 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Expression of non-TLR pattern recognition receptors in the spleen of BALB/c mice infected with Plasmodium yoelii and Plasmodium chabaudi chabaudi AS

Memorias do Instituto Oswaldo Cruz, 2012
The spleen plays a crucial role in the development of immunity to malaria, but the role of pattern recognition receptors (PRRs) in splenic effector cells during malaria infection is poorly understood.
Anna Rosanas-Urgell, Lorena Martin-Jaular, Julio Ricarte-Filho, Mireia Ferrer, Susana Kalko, Edna Kimura, Hernando A del Portillo   +6 more
doaj   +1 more source