Results 11 to 20 of about 4,265,108 (334)

Targeting of peptide‐binding receptors on cancer cells with peptide‐drug conjugates

, 2020
Specifically addressing cell surface molecules on cancer cells facilitates targeted cancer therapies that offer the potential to selectively destroy malignant cells, while sparing healthy tissue.
Dennis J Worm, Sylvia Els‐Heindl, A. Beck‐Sickinger   +2 more
semanticscholar   +1 more source

Muscarinic acetylcholine receptors. Peptide sequencing identifies residues involved in antagonist binding and disulfide bond formation.

Journal of Biological Chemistry, 1990
Muscarinic acetylcholine receptors (mAChR) were purified from rat brain and labeled either with the site-directed affinity label [3H]propylbenzilylcholine mustard (PrBCM) or with the sulfhydryl-specific label [3H]N-ethylmaleimide (NEM), using a protocol ...
E. Kurtenbach, C. Curtis, E. Pedder, A. Aitken, A. Harris, E. Hulme   +5 more
semanticscholar   +1 more source

Implication of Opioid Receptors in the Antihypertensive Effect of a Novel Chicken Foot-Derived Peptide

Biomolecules, 2020
The peptide AVFQHNCQE demonstrated to produce nitric oxide-mediated antihypertensive effect. This study investigates the bioavailability and the opioid-like activity of this peptide after its oral administration.
Anna Mas-Capdevila, Lisard Iglesias-Carres, Anna Arola-Arnal, Gerard Aragonès, Begoña Muguerza, Francisca Isabel Bravo   +5 more
doaj   +1 more source

Redistribution of critical major histocompatibility complex and T cell receptor-binding functions of residues in an antigenic sequence after biterminal substitution [PDF]

, 1991
Residues critical for establishing a trimolecular interaction with a major histocompatibility complex (MHC)-encoded receptor and a T cell antigen receptor (TcR) were determined for an antigenic nonapeptide. The N-terminal residue proved to be involved in
Allen, Bhayani, Bjorkman, Chen, DeLisi, Fox, Garrett, Kourilsky, Lorenz, Lurquin, Maryanski, Reddehase, Reddehase, Reddehase, Rothbard, Schultz, Schwartz, Sette, Townsend   +18 more
core   +1 more source

Structure-function analysis of the cloned opiate receptors: peptide and small molecule interactions.

Chemistry and Biology, 1996
Opiate receptors mediate the physiological actions of opioid peptides and the clinical effects of the synthetic opioid agonists and antagonists. Site-directed mutagenesis studies have revealed regions of opiate receptors that are essential for ligand ...
Allan D. Blake, George Bot, Terry Reisine   +2 more
semanticscholar   +1 more source

Computational Design of ACE2-Based Peptide Inhibitors of SARS-CoV-2

ACS Nano, 2020
Peptide inhibitors against the SARS-CoV-2 coronavirus, currently causing a worldwide pandemic, are designed and simulated. The inhibitors are mostly formed by two sequential self-supporting α-helices (bundle) extracted from the protease domain (PD) of ...
Yanxiao Han, P. Král
semanticscholar   +1 more source

A pentapeptide as minimal antigenic determinant for MHC class I-restricted T lymphocytes [PDF]

, 1989
Peptides that are antigenic for T lymphocytes are ligands for two receptors, the class I or II glycoproteins that are encoded by genes in the major histocompatibility complex, and the idiotypic / chain T-cell antigen receptor1–9. That a peptide must bind
A Sette, A Townsend, B Babbitt, C DeLisi, DW Thomas, GM Keil, H Margalit, H Volkmer, HC Bodmer, JB Rothbard, JB Rothbard, Jonathan B. Rothbard, M Del Val, Matthias J. Reddehase, MBA Oldstone, MF Good, MJ Reddehase, MJ Reddehase, MJ Reddehase, MM Davis, N Shastri, P Marrack, PJ Bjorkman, PM Allen, R Shimonkevitz, RH Schwartz, RH Schwartz, RM Zinkernagel, S Buus, UH Koszinowski, Ulrich H. Koszinowski   +30 more
core   +1 more source

Does kisspeptin belong to the proposed RF-amide peptide family?

Frontiers in Endocrinology, 2014
Kisspeptin (KISS) plays a key role in regulating reproduction by binding to its receptor, GPR54 (KISSR). Because of the Arg-Phe (RF) sequence at its carboxyl terminus, KISS has been proposed to be a member of the RF-amide peptide family consisting of ...
Seongsik eYun, Dong-Kyu eKim, Michael eFurlong, Jong-Ik eHwang, Hubert eVaudry, Jae Young eSeong   +5 more
doaj   +1 more source

The Formyl Peptide Receptors: Diversity of Ligands and Mechanism for Recognition

Molecules, 2017
The formyl peptide receptors (FPRs) are G protein-coupled receptors that transduce chemotactic signals in phagocytes and mediate host-defense as well as inflammatory responses including cell adhesion, directed migration, granule release and superoxide ...
Hui-qiong He, R. Ye
semanticscholar   +1 more source

Molecular Docking of SP40 Peptide towards Cellular Receptors for Enterovirus 71 (EV-A71)

Molecules, 2021
Enterovirus 71 (EV-A71) is one of the predominant etiological agents of hand, foot and mouth disease (HMFD), which can cause severe central nervous system infections in young children.
Malihe Masomian, Salima Lalani, Chit Laa Poh   +2 more
doaj   +1 more source