Results 21 to 30 of about 4,265,108 (334)

Synthesis, biological evaluation, and SAR studies of 14β-phenylacetyl substituted 17-cyclopropylmethyl-7, 8-dihydronoroxymorphinones derivatives : Ligands with mixed NOP and opioid receptor profile [PDF]

, 2018
© 2018 Kumar, Polgar, Cami-Kobeci, Thomas, Khroyan, Toll and Husbands.A series of 14β-acyl substituted 17-cyclopropylmethyl-7,8-dihydronoroxymorphinone compounds has been synthesized and evaluated for affinity and efficacy for mu (MOP), kappa (KOP), and ...
Cami-Kobeci, Champion, Cheng, Christoph, Ding, Dooley, Greedy, Greiner, Gumusel, Günther, Hu, Huang, Jenck, Khroyan, Khroyan, Kiguchi, Ko, Lewis, Lewis, Lia, Manabe, Meunier, Meunier, Mogil, Mollereau, Moynihan, Pomonis, Raffa, Reinsceid, Rizzi, Rossi, Saccone, Sandin, Schmidhammer, Schmidhammer, Schmidhammer, Spagnolo, Sukhtankar, Thompson, Toll, Toll, Traynor, Ueda, Vanderah, Váradi, Woodcock, Yu, Zeilhofer   +47 more
core   +4 more sources

Large-Scale Combinatorial Deorphanization of Platynereis Neuropeptide GPCRs

Cell Reports, 2015
Neuropeptides, representing the largest class of neuromodulators, commonly signal by G-protein-coupled receptors (GPCRs). While the neuropeptide repertoire of several metazoans has been characterized, many GPCRs are orphans.
Philipp Bauknecht, Gáspár Jékely
doaj   +1 more source

The gastrin-releasing peptide/bombesin system revisited by a reverse-evolutionary study considering Xenopus

Scientific Reports, 2021
Bombesin is a putative antibacterial peptide isolated from the skin of the frog, Bombina bombina. Two related (bombesin-like) peptides, gastrin-releasing peptide (GRP) and neuromedin B (NMB) have been found in mammals.
Asuka Hirooka, Mayuko Hamada, Daiki Fujiyama, Keiko Takanami, Yasuhisa Kobayashi, Takumi Oti, Yukitoshi Katayama, Tatsuya Sakamoto, Hirotaka Sakamoto   +8 more
doaj   +1 more source

Predicting the composition of red wine blends using an array of Multicomponent peptide-based sensors [PDF]

, 2015
Differential sensing using synthetic receptors as mimics of the mammalian senses of taste and smell is a powerful approach for the analysis of complex mixtures.
Abdi, Andrea Navarro, Ashley Cubley, Eman Ghanem, Eric Anslyn, Federico Marini, Helene Hopfer, Hildegarde Heymann, Jessica Bolen, Katherine Teasdale, Lina Mahmood, Linh Lieu, Maxwell Ritzer, Morgan Fredell, Rabia Fattah, Tedmund Chua, Umali, Weekley, Yamane   +18 more
core   +4 more sources

Glucagon-Like Peptide-1 and Its Class B G Protein–Coupled Receptors: A Long March to Therapeutic Successes

Pharmacological Reviews, 2016
The glucagon-like peptide (GLP)-1 receptor (GLP-1R) is a class B G protein–coupled receptor (GPCR) that mediates the action of GLP-1, a peptide hormone secreted from three major tissues in humans, enteroendocrine L cells in the distal intestine, α cells ...
C. de Graaf, D. Donnelly, D. Wootten, J. Lau, P. Sexton, L. Miller, Jung-Mo Ahn, Jia-yu Liao, Madeleine M. Fletcher, Dehua Yang, Alastair J. H. Brown, Cai-hong Zhou, Jiejie Deng, Ming-Wei Wang   +13 more
semanticscholar   +1 more source

Peptide ligand recognition by G protein-coupled receptors

Frontiers in Pharmacology, 2015
The past few years have seen spectacular progress in the structure determination of G protein-coupled receptors (GPCRs). We now have structural representatives from classes A, B, C, and F.
Brian E Krumm, Reinhard eGrisshammer
doaj   +1 more source

Involvement of mammalian RF-amide peptides and their receptors in the modulation of nociception in rodents

Frontiers in Endocrinology, 2014
Mammalian RF-amide peptides, which all share a conserved carboxyl-terminal Arg-Phe-NH2 sequence, constitute a family of five groups of neuropeptides that are encoded by five different genes.
Safia eAyachi, Frederic eSimonin
doaj   +1 more source

Evolution of a potential hormone antagonist following gene splicing during primate evolution. [PDF]

PLoS ONE, 2013
Alternative splicing of genes generates novel mRNAs, leading to the evolution of new functional proteins. Cholecystokinin (CCK) induces the release of pancreatic enzymes and the contraction of the gallbladder to promote the digestion of fat and proteins.
Cheng Deng, Aaron J W Hsueh
doaj   +1 more source

The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach [PDF]

, 2013
The calcitonin gene-related peptide (CGRP) receptor is a complex of a calcitonin receptor-like receptor (CLR), which is a family B G-protein-coupled receptor (GPCR) and receptor activity modifying protein 1.
Alex C. Conner, Barwell J, Bruck Taddese, Christopher A. Reynolds, Conner AC, David R. Poyner, Debbie L. Hay, Harriet A. Watkins, James Barwell, Kevin J. Smith, Michael. J. Woolley, Urano D, Watkins HA, Z. Gamze Karakullukcu   +13 more
core   +2 more sources

Formyl Peptide Receptor as a Novel Therapeutic Target for Anxiety-Related Disorders [PDF]

, 2014
Formyl peptide receptors (FPR) belong to a family of sensors of the immune system that detect microbe-associated molecules and inform various cellular and sensorial mechanisms to the presence of pathogens in the host.
A Alam, A Strohle, AC Carpenter, AK Sato, AL Stenfeldt, BA Babbin, C Gemperle, C Marquez, C Touma, CA Janeway Jr, CC Wentworth, CC Wentworth, CK Derian, D El Kebir, D Yang, D Yang, DA Christakis, DE Ganella, E Krump, Elisabetta Panza, F Cattaneo, F Miceli, F Sallusto, FA Costa-Pinto, FN Gavins, FN Gavins, Fulvio D'Acquisto, G De Palma, G Taglialatela, Giuseppa Piras, GT Condo, H Lim, H Mou, IA Olsson, IJ Santos-Soto, Irene Gallo, JA Foster, Jeffrey W. Dalley, JF Cryan, JF Cryan, JL Barr, JL Gao, JL Leasure, JP Onnela, JW Jahng, K Chen, K Chen, KL McIlwain, KM Neufeld, L Spurr, LM Sutton, Lorenza Rattazzi, M Antunes, M Aoki, M Bourin, M Bourin, M Keitoku, M Perretti, M Saigo, MA Panaro, Mauro Perretti, MG Gareau, MJ Molloy, MJ Rane, MM van Gaalen, N Benaroya-Milshtein, N Dufton, N Dufton, P Anton, Q Wang, Q Zhang, R Diaz Heijtz, R Luisi, R Medzhitov, RD Ye, RM Deacon, RM Deacon, RM Deacon, RN Walsh, RS Kasai, S Fediuc, S Ihara, S Kedia, S Park, S Pellow, S Riviere, SB Su, SC Heo, SD Liberles, SD Munger, SN Cooray, T Sato, Thomas Gobbetti, Tiziana Rubino, TJ Schoenfeld, V Marashi, Y De, YH Cui, YH Cui   +98 more
core   +6 more sources