Results 91 to 100 of about 45,895 (246)

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

P2X4: A fast and sensitive purinergic receptor

Biomedical Journal, 2017
Extracellular nucleotides have been recognized as important mediators of activation, triggering multiple responses via plasma membrane receptors known as P2 receptors. P2 receptors comprise P2X ionotropic receptors and G protein-coupled P2Y receptors.
Suurväli, Jaanus, Boudinot, Pierre, Kanellopoulos, Jean, Rüütel Boudinot, Sirje   +3 more
openaire   +5 more sources

Isolation and characterization of Pisum sativum apyrases, PsNTP9 and PsNTP9-DM, cloned and expressed in Escherichia coli [PDF]

, 2019
Adenosine triphosphate (ATP) is widely known as a fuel source for many biochemical processes, and to a lesser degree also as a signaling molecule in plants and animals.
Wallen, Michael Andrew, Jr
core   +1 more source

P2X7 receptor inhibition ameliorates dendritic spine pathology and social behavioral deficits in Rett syndrome mice

Nature Communications, 2020
P2X7 receptors are purinergic receptors with pro-inflammatory functions. Here, the authors show that inhibition of leukocyte P2X7 receptors reduces dendritic spine pathology and social behavioral deficits in a mouse model of Rett syndrome.
Juan Mauricio Garré, Hernandez Moura Silva, Juan J. Lafaille, Guang Yang   +3 more
doaj   +1 more source

Role of astrocyte in neuroinflammation‐induced loss in neuroplasticity and subsequent onset of depression: A systematic review

Neuroprotection, EarlyView.
Mechanistic crosstalk between microglia and astrocytes in major depressive disorder. Abstract Major depressive disorder (MDD) is a complex psychiatric condition increasingly linked to chronic neuroinflammation, particularly in the context of aging, stress, and systemic comorbidities.
Gaurav Singhal, Saurabh Singhal, Bernhard T. Baune   +2 more
wiley   +1 more source

P2X receptors: epithelial ion channels and regulators of salt and water transport. [PDF]

, 2008
When the results from electrophysiological studies of renal epithelial cells are combined with data from in vivo tubule microperfusion experiments and immunohistochemical surveys of the nephron, the accumulated evidence suggests that ATP-gated ion ...
Brian F. King, Bucheimer RE, Dai LJ, Dubyak GR, Egan TM, Inscho EW, King BF, Lazarowski ER, Lazarowski ER, Lehrmann H, Leipziger J, Li L, McCoy DE, North RA, Pelegrin P, Piper AS, Ralevic V, Schwiebert EM, Scott S.P. Wildman, Shirley DG, Taylor AL, Unwin RJ, Vekaria R, Wildman SS, Wildman SS, Wildman SS, Wildman SS, Wildman SS, Wolff SC, Zhang Y   +29 more
core   +1 more source

Effect of P2Y12 Inhibitors on Major Adverse Cardiovascular Events After Coronary Artery Bypass Graft Surgery: A Population‐Based Cohort Study

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
ABSTRACT Background Patients who undergo coronary artery bypass graft (CABG) surgery remain at high risk for major adverse cardiovascular events (MACE) despite contemporary preventive pharmacotherapy. Although commonly used in practice, it is uncertain whether P2Y12 inhibitors reduce MACE in patients post‐CABG surgery.
Arden R. Barry, Hamed Helisaz, Abdollah Safari, Peter S. Loewen   +3 more
wiley   +1 more source

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury. [PDF]

, 2019
Traumatic spinal cord injury (SCI) brings numerous inflammatory cells, including macrophages, from the circulating blood to lesions, but pathophysiological impact resulting from spatiotemporal dynamics of macrophages is unknown.
Edgerton, V Reggie, Hara, Masamitsu, Harimaya, Katsumi, Inoue, Kazuhide, Iwamoto, Yukihide, Kijima, Ken, Kobayakawa, Kazu, Kubota, Kensuke, Masuda, Takahiro, Matsumoto, Yoshihiro, Nakashima, Yasuharu, Ohkawa, Yasuyuki, Okada, Seiji, Ozato, Keiko, Saito, Takeyuki, Tamaru, Tetsuya, Tamura, Tomohiko, Tsuda, Makoto, Yokota, Kazuya, Yoshizaki, Shingo   +19 more
core   +1 more source

Purinergic signaling in the modulation of redox biology

Redox Biology, 2021
Purinergic signaling is a cell communication pathway mediated by extracellular nucleotides and nucleosides. Tri- and diphosphonucleotides are released in physiological and pathological circumstances activating purinergic type 2 receptors (P2 receptors ...
Luiz Eduardo Baggio Savio, Raíssa Leite-Aguiar, Vinícius Santos Alves, Robson Coutinho-Silva, Angela T.S. Wyse   +4 more
doaj  

Human and Mouse Alzheimer's Seeds Differentially Affect Amyloid Deposition and Microglia‐Dependent Plaque Response in Aged Mice

Aging Cell, EarlyView.
This study shows that human and mouse brains contain a different pool of strains that differentially affect the formation of Aβ and tau aggregates. Moreover, the murine seeds trigger an unresponsiveness microglial state, which causes the loss of plaque microglial coverage and affects the formation of amyloid plaques, leading to more severe neuritic ...
Juana Andreo‐Lopez, Cristina Nuñez‐Diaz, Kelly Do Huynh, Marie Minh Thu Nguyen, Celia Da Cunha, Francisco J. Cantero‐Molina, Cynthia Campos‐Moreno, Stefania Zimbone, Francesco Bellia, Maria Laura Giuffrida, Laura Trujillo‐Estrada, Juan Antonio Garcia‐Leon, Miriam Bettinetti‐Luque, Nazaret Gamez, Catalina Valdes, Rodrigo Morales, Stefania Forner, Alessandra C. Martini, Antonia Gutierrez, Frank M. LaFerla, David Baglietto‐Vargas   +20 more
wiley   +1 more source