Results 121 to 130 of about 45,895 (246)

Purinergic receptors in the endocrine and exocrine pancreas [PDF]

Purinergic Signalling, 2007
The pancreas is a complex gland performing both endocrine and exocrine functions. In recent years there has been increasing evidence that both endocrine and exocrine cells possess purinergic receptors, which influence processes such as insulin secretion and epithelial ion transport. Most commonly, these processes have been viewed separately.
openaire   +4 more sources

Recent advances in the structure, function and regulation of the volume‐regulated anion channels and their role in immunity

The Journal of Physiology, EarlyView.
Abstract figure legend The volume‐regulated anion channel (VRAC), composed of leucine‐rich repeat‐containing 8 (LRRC8) proteins, serves both canonical and non‐canonical functions in vertebrate cells. The canonical function of this channel relates to its original description, which is homeostatic regulation of cell volume in response to hypotonic ...
Sergei Yanushkevich, Aleksandra Zieminska, Joshua Gonzalez, Francisca Añazco, Richard Song, Alejandra Arias‐Cavieres, Sara T. Granados, Junyi Zou, Yan Rao, Axel R. Concepcion   +9 more
wiley   +1 more source

Targeting Purinergic Receptors in Islet Transplantation [PDF]

Diabetes, 2013
Transplanted islets are exposed to a distinctively hostile immunological environment. Grafted islets typically encounter a combination of innate, allogeneic and anti-islet immune responses—the relative contributions of which are not fully understood.
openaire   +2 more sources

Aspirin-dependent effects on purinergic P2Y1 receptor express [PDF]

, 2019
Chronic treatment with aspirin in healthy volunteers (HVs) is associated with recovery of adenosine diphosphate (ADP)-induced platelet activation. The purinergic P2Y1 receptor exerts its effects via a Gq-protein, which is the same biochemical pathway ...
Alemanno, Laura, Angiolillo, Dominick J, Ceccacci, Andrea, Frati, Luigi, Guarino, Maria Luisa, Guerriero, Raffaella, Mancone, Massimo, Massimi, Isabella, Pulcinelli, Fabio M   +8 more
core   +1 more source

Dual role for pannexin 1 at synapses: regulating functional and morphological plasticity

The Journal of Physiology, EarlyView.
Abstract figure legend Pannexin 1 (PANX1) regulation of dendritic spines. The postnatal decrease in PANX1 expression could release key spine cytoskeleton‐regulating proteins enabling spine stabilization. Does the physiological decrease in neuronal PANX1 levels across brain development underlie dendritic spine maturation?
Adriana Casillas Martinez, Leigh E. Wicki‐Stordeur, Annika V. Ariano, Leigh Anne Swayne   +3 more
wiley   +1 more source

P2 purinoceptors signaling in fibroblasts of rat subcutaneous tissue [PDF]

, 2011
Mestrado em Biologia Molecular e CelularO tecido conjuntivo parece estar envolvido na génese de diversas condições patológicas. O aumento da rigidez do tecido conjuntivo, resultante da fibrose, pode constituir um factor importante no mecanismo patogénico
Reis, Carla Patrícia da Silva e Sousa
core   +1 more source

Inhibition and potentiation of the exercise pressor reflex by pharmacological modulation of TRPC6 in male rats

The Journal of Physiology, EarlyView.
Abstract figure legend The majority of L4–L5 dorsal root ganglion cells innervating the triceps surae muscles of healthy rats expressed TRPC6 channels. In decerebrated rats, pharmacological inhibition of TRPC6 channels by injection of antagonists (SAR7334 or BI‐749327) into the arterial supply of the triceps surae muscles inhibited the exercise pressor
Guillaume P. Ducrocq, Laura Anselmi, Salvatore L. Stella Jr, Steven W. Copp, Victor Ruiz‐Velasco, Marc P. Kaufman   +5 more
wiley   +1 more source

Chemoreflex function in pulmonary diseases – A review

The Journal of Physiology, EarlyView.
Abstract figure legend Chemoreflex activation in respiratory diseases and COVID‐19 populations. Abstract The chemoreflex is a vital protective reflex that is crucial in restoring normal blood gas and pH levels. The carotid bodies are peripheral chemoreceptors activated by hypoxia (primarily), hypercapnia, acidaemia, temperature, lactate and potassium ...
Kajal Kamra, Zhiqiu Xia, Irving H. Zucker, Harold Schultz, Han‐Jun Wang   +4 more
wiley   +1 more source

Purinergic receptors in multiple sclerosis pathogenesis

Brain Research Bulletin, 2019
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system, characterized by the presence of focal lesions in white and grey matter with peripheral immune cells infiltration. Purinergic receptors control immune cell function as well as neuronal and oligodendroglial survival, and the activation of astrocytes ...
Alazne Zabala, Carlos Matute, María Domercq   +2 more
openaire   +3 more sources

Sphingosine‐1‐phosphate activates LRRC8 volume‐regulated anion channels through Gβγ signalling

The Journal of Physiology, EarlyView.
Abstract figure legend Sphingosine‐1‐phosphate (S1P) binds to Gi protein‐coupled receptor S1PR1. Upon S1PR1 activation, Gβγ is released from the Gαi‐Gβγ heterotrimer, allowing it to recruit phospholipase Cβ (PLCβ) to the plasma membrane. PLCβ cleaves phosphatidylinositol‐4,5‐bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG).
Yulia Kostritskaia, Sumaira Pervaiz, Anna Klemmer, Malte Klüssendorf, Tobias Stauber   +4 more
wiley   +1 more source