Results 31 to 40 of about 45,895 (246)

Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death [PDF]

, 2010
The purinergic signalling system, which uses purines and pyrimidines as chemical transmitters, and purinoceptors as effectors, is deeply rooted in evolution and development and is a pivotal factor in cell communication.
A Gartland, A Hoebertz, A Surprenant, A Trautmann, A Verkhratsky, AN Drury, AV Gourine, AV Greig, AV Greig, AV Greig, AV Greig, AV Greig, AV Greig, B Hechler, B Johansson, B Vandewalle, BB Fredholm, BB Fredholm, BS Khakh, BS Khakh, C Giaume, C Ledent, C Ponnamperuma, CA Salvatore, CH Fiske, CI Seye, CJ Dixon, D Erlinge, DA Cockayne, E Ghanem, E Rapaport, EB Gonzales, EW Inscho, EW Sutherland, F Di Virgilio, F Di Virgilio, F Di Virgilio, F Lippman, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Clark, H Franke, H Woodward, H Zimmermann, HZ Ke, I Bar, IF Gow, IP Chessell, J Korcok, J Li, J Nilsson, JA Burgers, JA Sim, JE Wilson, JF Chen, JF Chen, JL Madara, JM Armstrong, JM Sanz, JT Neary, K Inoue, K Inoue, K Inoue, K Lohmann, K Mulryan, K Wirkner, K Yamamoto, KA Moore, L Gimenez-Llort, L Li, M Horckmans, M Naassila, M Ryten, M Shabbir, M Shabbir, M Shabbir, M Sugioka, M Tsuda, MJ Bours, MJ Ludlow, MM Waldrop, MP Abbracchio, MP Abbracchio, MP Abbracchio, MP Abbracchio, MP Abbracchio, MP Abbracchio, MP Meyer, MW Grol, MW Verghese, MY Avila, N Lenain, N Panupinthu, N White, N White, N White, PB Conley, R Brown, R Janssens, RA North, RA North, RJ Cerniway, S Kirischuk, S Kirischuk, S Pochet, S Ryzhov, SD Ohlendorff, SJ Fountain, SJ Fountain, SL Tilley, T Kawate, TE Finger, U Groschel-Stewart, U Groschel-Stewart, UK Hanisch, V Ralevic, V Ralevic, V Souslova, VL Cressman, X Bian, X Hua, Y Guo, Y Pankratov, Y Pankratov, Y Pankratov, Y Pankratov, YD Bogdanov, Z Xiang, Z Zhao   +139 more
core   +2 more sources

The Second Transmembrane Domain of P2X7 Contributes to Dilated Pore Formation [PDF]

, 2013
Activation of the purinergic receptor P2X7 leads to the cellular permeability of low molecular weight cations. To determine which domains of P2X7 are necessary for this permeability, we exchanged either the C-terminus or portions of the second ...
A MacKenzie, A Surprenant, AN Shemon, B Gu, BC Suh, BJ Gu, BJ Gu, BM Saunders, BS Khakh, BS Khakh, C Andrei, C Marques-da-Silva, C Sun, C Virginio, Chengqun Sun, CP Lai, D Leon, D Zink, DS Emmett, DS Samways, E Adinolfi, E Bulanova, F Bretschneider, F Rassendren, G Girolomoni, H Gunosewoyo, HJ Bradley, HM Costa-Junior, HZ Hu, JS Wiley, K Schroder, KA Hillman, L Gudipaty, L Stokes, LC Denlinger, LC Denlinger, LE Browne, LH Jiang, LH Jiang, M Li, M Li, Michelle E. Heid, ML Gavala, ML Smart, MT Miras-Portugal, P Marin-Garcia, P Pelegrin, P Pelegrin, Peter A. Keyel, Pierre Bobé, Q Li, R Sluyter, RA North, Russell D. Salter, S Chaumont, S Kracun, S Locovei, S Penuela, S Roger, SD Ohlendorff, SD Silberberg, SL Fernando, SL Fernando, T Kawate, T Sugiyama, TM Egan, V Petrilli, W Duckwitz, Y Shinozaki   +68 more
core   +13 more sources

Purinergic signaling: A gatekeeper of blood-brain barrier permeation

Frontiers in Pharmacology, 2023
This review outlined evidence that purinergic signaling is involved in the modulation of blood-brain barrier (BBB) permeability. The functional and structural integrity of the BBB is critical for maintaining the homeostasis of the brain microenvironment.
Yuemei Wang, Yuanbing Zhu, Junmeng Wang, Longcong Dong, Shuqing Liu, Sihui Li, Qiaofeng Wu   +6 more
doaj   +1 more source

Extracellular ATP drives systemic inflammation, tissue damage and mortality [PDF]

, 2014
Systemic inflammatory response syndromes (SIRS) may be caused by both infectious and sterile insults, such as trauma, ischemia-reperfusion or burns. They are characterized by early excessive inflammatory cytokine production and the endogenous release of ...
Brouckaert, Peter, Cauwels, Anje, Rogge, Elke, Shiva, S, Vandendriessche, Benjamin   +4 more
core   +1 more source

The Role of Purinergic Receptors in the Circadian System [PDF]

International Journal of Molecular Sciences, 2020
The circadian system is an internal time-keeping system that synchronizes the behavior and physiology of an organism to the 24 h solar day. The master circadian clock, the suprachiasmatic nucleus (SCN), resides in the hypothalamus. It receives information about the environmental light/dark conditions through the eyes and orchestrates peripheral ...
Amira A.H. Ali, Gayaneh Avanes Avakian, Charlotte Von Gall   +2 more
openaire   +2 more sources

Purinergic Signaling and Related Biomarkers in Depression

Brain Sciences, 2020
It is established that purinergic signaling can shape a wide range of physiological functions, including neurotransmission and neuromodulation. The purinergic system may play a role in the pathophysiology of mood disorders, influencing neurotransmitter ...
Francesco Bartoli, Geoffrey Burnstock, Cristina Crocamo, Giuseppe Carrà   +3 more
doaj   +1 more source

Prenatal exposure to valproic acid induces alterations in the expression and activity of purinergic receptors in the embryonic rat brain

Folia Neuropathologica, 2022
Purinergic signalling is involved in the control of several processes related to brain development, such as neurogenesis and gliogenesis, migration and differentiation of neuronal precursors, synaptogenesis and synaptic elimination to achieve a fully ...
Lidia Babiec, Anna Wilkaniec, Agata Adamczyk   +2 more
doaj   +1 more source

Role of Pannexin-1 hemichannels and purinergic receptors in the pathogenesis of human diseases

Frontiers in Physiology, 2014
In the last decade several groups have determined the key role of hemichannels formed by pannexins or connexins, extracellular ATP and purinergic receptors in physiological and pathological conditions.
Stephani eVelasquez, Stephani eVelasquez, Eliseo A Eugenin, Eliseo A Eugenin   +3 more
doaj   +1 more source

Purines, Purinergic Receptors, and Cancer [PDF]

Cancer Research, 2012
AbstractPurines were long thought to be restricted to the intracellular compartment, where they are used for energy transactions, nucleic acid synthesis, and a multiplicity of biochemical reactions. However, it is now clear that both adenosine and adenosine triphosphate are (i) abundant biochemical components of the tumor microenvironment, (ii) potent ...
openaire   +4 more sources

Activation of the P2Y2 receptor regulates bone cell function by enhancing ATP release [PDF]

, 2017
Bone cells constitutively release ATP into the extracellular environment where it acts locally via P2 receptors to regulate bone cell function. Whilst P2Y2 receptor stimulation regulates bone mineralisation, the functional effects of this receptor in ...
Arnett, T R, Gueneri, D, Hajjawai, M O, Orriss, I R, Patel, J J, Shaw, K   +5 more
core   +2 more sources