Results 1 to 10 of about 7,951 (196)

Systematic analyses of the sequence conservation and ligand interaction patterns of purinergic P1 and P2Y receptors provide a structural basis for receptor selectivity

Computational and Structural Biotechnology Journal, 2023
Purinergic receptors are membrane proteins that regulate numerous cellular functions by catalyzing reactions involving purine nucleotides or nucleosides. Among the three receptor families, i.e., P1, P2X, and P2Y, the P1 and P2Y receptors share common structural features of class A GPCR.
Ri Han, Hongryul Yoon, Jiho Yoo, Yoonji Lee   +3 more
openaire   +4 more sources

Purinergic receptors in adipose tissue as potential targets in metabolic disorders [PDF]

Frontiers in Pharmacology, 2017
Extracellular nucleosides and nucleotides, such as adenosine and adenosine triphosphate (ATP), are involved in many physiological and pathological processes in adipose tissue (AT).
Novak, Ivana, Tozzi, Marco
core   +8 more sources

Purinergic Signaling and Aminoglycoside Ototoxicity: The Opposing Roles of P1 (Adenosine) and P2 (ATP) Receptors on Cochlear Hair Cell Survival [PDF]

Frontiers in Cellular Neuroscience, 2019
Purinergic signaling regulates important physiological processes and the homeostatic response to stress in the cochlea via extracellular nucleosides (adenosine) and nucleotides (ATP, UTP). Using a previously established organotypic culture model, the current study investigated the effect of purinergic P1 (adenosine) and P2 (ATP) receptor activation on ...
Srdjan M. Vlajkovic, Peter R. Thorne, Shelly C. Y. Lin, Gary D. Housley   +3 more
openaire   +5 more sources

Role of P1 purinergic receptors in myocardial ischemia sensory transduction [PDF]

Cardiovascular Research, 2002
To characterize the role that cardiac sensory P(1) purinergic (adenosine A(1) or A(2)) receptors play in transducing myocardial ischemia.Porcine nodose ganglion cardiac sensory neuron adenosine A(1) or A(2) receptor function was studied in situ during control states as well as in the presence of the peptides bradykinin and substance P or focal ...
Gregory W Thompson, Magda Horackova, John A Armour   +2 more
openaire   +3 more sources

Role of purines in brain development, from neuronal proliferation to synaptic refinement [PDF]

, 2023
© 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)The purinergic system includes P1 and P2 receptors, which are activated by ATP and its metabolites.
Lévi, Sabine, Moreira, João B., Rimbert, Solen, Xapelli, Sara   +3 more
core   +1 more source

Editorial: Purinergic Pharmacology [PDF]

, 2020
The purine nucleotides and nucleosides constitute important extracellular signaling molecules acting as neurotransmitters and neuromodulators. Indeed, extracellular adenosine 5′-triphosphate (ATP) and adenosine, tightly controlled by nucleotidases ...
Ciruela Alférez, Francisco, Jacobson, Kenneth A.   +1 more
core   +1 more source

Purines as Transmitter Molecules: Electrophysiological Studies on Purinergic Signalling in Different Cell Systems [PDF]

, 2022
Purinergic nucleotides and nucleosides (ATP, ADP, AMP and adenosine) are essential intracellular metabolites involved in a number of cellular processes, from energy supply to protein phosphorylation.
COPPI, Elisabetta
core   +1 more source

Functions of Purinergic Receptors [PDF]

, 2019
Purinergic receptors, also known as purinoceptors, are a family of plasma membrane molecules found in many mammalian tissues. Purinergic receptors are transmembrane receptors consisting of two main categories.
Sarikaya, Eren
core   +2 more sources

Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death [PDF]

, 2010
The purinergic signalling system, which uses purines and pyrimidines as chemical transmitters, and purinoceptors as effectors, is deeply rooted in evolution and development and is a pivotal factor in cell communication.
A Gartland, A Hoebertz, A Surprenant, A Trautmann, A Verkhratsky, AN Drury, AV Gourine, AV Greig, AV Greig, AV Greig, AV Greig, AV Greig, AV Greig, B Hechler, B Johansson, B Vandewalle, BB Fredholm, BB Fredholm, BS Khakh, BS Khakh, C Giaume, C Ledent, C Ponnamperuma, CA Salvatore, CH Fiske, CI Seye, CJ Dixon, D Erlinge, DA Cockayne, E Ghanem, E Rapaport, EB Gonzales, EW Inscho, EW Sutherland, F Di Virgilio, F Di Virgilio, F Di Virgilio, F Lippman, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Clark, H Franke, H Woodward, H Zimmermann, HZ Ke, I Bar, IF Gow, IP Chessell, J Korcok, J Li, J Nilsson, JA Burgers, JA Sim, JE Wilson, JF Chen, JF Chen, JL Madara, JM Armstrong, JM Sanz, JT Neary, K Inoue, K Inoue, K Inoue, K Lohmann, K Mulryan, K Wirkner, K Yamamoto, KA Moore, L Gimenez-Llort, L Li, M Horckmans, M Naassila, M Ryten, M Shabbir, M Shabbir, M Shabbir, M Sugioka, M Tsuda, MJ Bours, MJ Ludlow, MM Waldrop, MP Abbracchio, MP Abbracchio, MP Abbracchio, MP Abbracchio, MP Abbracchio, MP Abbracchio, MP Meyer, MW Grol, MW Verghese, MY Avila, N Lenain, N Panupinthu, N White, N White, N White, PB Conley, R Brown, R Janssens, RA North, RA North, RJ Cerniway, S Kirischuk, S Kirischuk, S Pochet, S Ryzhov, SD Ohlendorff, SJ Fountain, SJ Fountain, SL Tilley, T Kawate, TE Finger, U Groschel-Stewart, U Groschel-Stewart, UK Hanisch, V Ralevic, V Ralevic, V Souslova, VL Cressman, X Bian, X Hua, Y Guo, Y Pankratov, Y Pankratov, Y Pankratov, Y Pankratov, YD Bogdanov, Z Xiang, Z Zhao   +139 more
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ATP as a presynaptic modulator [PDF]

, 2000
© 2000 Elsevier Science Inc.There is considerable evidence that ATP acts as a fast transmitter or co-transmitter in autonomic and sensory nerves mostly through activation of ionotropic P2X receptors but also through metabotropic P2Y receptors. By analogy,
Cunha, Rodrigo A., Ribeiro, J. A.
core   +1 more source